BGC0000566: streptolysin S biosynthetic gene cluster from Streptococcus pyogenes M1 GAS
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Location: 598,677 - 606,966 nt. (total: 8,290 nt).
This entry is originally from NCBI GenBank AE004092.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000566
Short description streptolysin S biosynthetic gene cluster from Streptococcus pyogenes M1 GAS
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
AE004092.2
598677 - 606966
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • streptolysin S
Species Streptococcus pyogenes M1 GAS [taxonomy]
References
Chemical products information
streptolysin S Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SPy_0738
  • AAK33684.1
  • sagA
 598677 - 598838 (+) RiPP precursor peptide
  • Precursor biosynthesis
  • Knock-out Heterologous expression Activity assay
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  • SPy_0739
  • AAK33685.1
  • sagB
 599060 - 600010 (+) Dehydrogenase
  • Tailoring
  • Heterologous expression Activity assay
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  • SPy_0740
  • AAK33686.1
  • sagC
 600007 - 601065 (+) Cyclodehydratase partner
  • Tailoring
  • Heterologous expression Activity assay
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  • SPy_0741
  • AAK33687.1
 601085 - 602443 (+) Cyclodehydratase
  • Tailoring
  • Heterologous expression Activity assay
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  • SPy_0742
  • AAK33688.1
 602418 - 603089 (+) Putative protease
  • Activation / processing
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  • SPy_0743
  • AAK33689.1
 603086 - 603769 (+) hypothetical protein
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    • SPy_0744
    • AAK33690.1
    		 603792 - 604715 (+) ABC transporter
    • Transport
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    • SPy_0745
    • AAK33691.1
    • sagH
    		 604724 - 605851 (+) ABC transporter
    • Transport
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    • SPy_0746
    • AAK33692.1
    		 605848 - 606966 (+) ABC transporter
    • Transport
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    Biosynthesis information
    Annotation changelog

    Entry version: 4

    Date
    Changes
    Submitters
    Reviewers
    2022-10-07
    Update chemical activity to schema version 2.11
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 3

    Date
    Changes
    Submitters
    Reviewers
    2022-09-15
    Remove negative molecular mass
    • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 2

    Date
    Changes
    Submitters
    Reviewers
    2019-10-16
    Migrated from v1.4
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

    Entry version: 1

    Date
    Changes
    Submitters
    Reviewers
    2015-06-12
    Submitted
    • (ID: FTVL3IN3CWSJUJDTYVJJVU23)
    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
    Similar known gene clusters from MIBiG 4.0
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