BGC0000581: microcin J25 biosynthetic gene cluster from Escherichia coli AY25
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Location: 1 - 4,803 nt. (total: 4,803 nt).
This entry is originally from NCBI GenBank AF061787.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
Tailoring
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000581
Short description microcin J25 biosynthetic gene cluster from Escherichia coli AY25
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "BGC was originally isolated from a plasmid: see DOI: 10.1128/jb.181.8.2659-2662.1999"
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
AF061787.1
1 - 4496
via Heterologous expression
Compounds
  • microcin J25
Species Escherichia coli AY25 [taxonomy]
References
Chemical products information
microcin J25 Evidence:
Copy SMILES
C101H139N23O27
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAD28494.1
  • mcjA
 62 - 238 (-) RiPP precursor peptide
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    • AAD28495.1
    • mcjB
    		 578 - 1204 (+) Hydrolase
    • Hydrolysis
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    • AAD28496.1
    • mcjC
    		 1207 - 2535 (+) Macrolactam formation
    • Macrolactam formation
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    • AAD28497.1
    • mcjD
    		 2754 - 4496 (+) McjD
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      Biosynthesis information

      No biosynthesis information available for this record.

      Annotation changelog

      Entry version: 6

      Date
      Changes
      Submitters
      Reviewers
      2024-07-23
      MIBiG v4 annotathon
      • (ID: G42B4RI57WLTDHDCD4PMU3MJ)
      • (ID: C62OJVVH7XOTOTFZSJT727YU)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: next

      Date
      Changes
      Submitters
      Reviewers
      2023-10-18
      Added locus coordinates, evidence, completeness, bioactivity, precursor peptide-gene information. Changed PubMed IDs to DOIs, changed subclass to 'Lassopeptide'. Corrected SMILES structure. Added gene product annotation. Added correct strain identifier.
      • (ID: C62OJVVH7XOTOTFZSJT727YU)
      • (ID: RKFOW2BJ2UIGZ6GYHFZX4BHF)

      Entry version: 4

      Date
      Changes
      Submitters
      Reviewers
      2022-10-07
      Update chemical activity to schema version 2.11
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 3

      Date
      Changes
      Submitters
      Reviewers
      2022-09-15
      Updated bioactivity data
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 2

      Date
      Changes
      Submitters
      Reviewers
      2019-10-16
      Migrated from v1.4
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2019-10-16
      Updated compound(s) information (NPAtlas curation)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

      Entry version: 1

      Date
      Changes
      Submitters
      Reviewers
      2015-06-12
      Submitted
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      Tailoring functions
      Tailoring enzymes detected in this region
      Hydrolases: Hydrolysis
      mcjB: Hydrolysis
      MITE
      MITE0000056Hydrolysis (identity: 100.00%)
      Ligases: Macrolactam formation
      mcjC: Macrolactam formation
      MITE
      MITE0000055Macrolactam formation (identity: 100.00%)
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      Location:

      Identifier
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