BGC0000582: cypemycin biosynthetic gene cluster from Streptomyces sp. OH-4156
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Location: 1 - 12,148 nt. (total: 12,148 nt).
This entry is originally from NCBI GenBank HQ148718.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000582
Short description cypemycin biosynthetic gene cluster from Streptomyces sp. OH-4156
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Paper reporting the cypemycin structure is not archived in PubMed:\nMinami Y, et al. (1994) Structure of cypemycin, a new peptide antibiotic. Tetrahedron Lett 35:8001-8004"
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
HQ148718.1
via Knock-out studies, Enzymatic assays, Heterologous expression, Gene expression correlated with compound production
Compounds
  • cypemycin
Species Streptomyces sp. OH-4156 [taxonomy]
References
Chemical products information
cypemycin Evidence:
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C99H154N24O24S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADR72961.1
 57 - 3308 (-) putative regulatory protein
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    • ADR72962.1
    		 3882 - 4076 (+) cypemycin structural protein
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      • ADR72963.1
      		 4191 - 5945 (+) hypothetical protein
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        • ADR72964.1
        		 5935 - 6495 (+) unknown
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          • ADR72965.1
          		 6492 - 7064 (+) HFCD family decarboxylase
          • Tailoring
          • Knock-out Activity assay
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          • ADR72966.1
          		 7057 - 7794 (+) SAM-dependent methyltransferase
          • Tailoring
          • Knock-out Activity assay
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          • ADR72967.1
          		 7791 - 8423 (+) ABC transporter ATP binding subunit
          • Transport
          • Knock-out Activity assay
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          • ADR72968.1
          		 8420 - 9970 (+) putative transmembrane pore
          • Transport
          • Knock-out Activity assay
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          • ADR72969.1
          		 10053 - 12074 (+) DUF255 family protein
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            Biosynthesis information
            Annotation changelog

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2019-10-16
            Updated compound(s) information (NPAtlas curation)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2015-06-12
            Submitted
            • (ID: SJOI7JSMELHUIOC3HESCTFXV)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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