BGC0000691: acarbose biosynthetic gene cluster from Actinoplanes sp. SE50/110
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Location: 1 - 41,323 nt. (total: 41,323 nt).
This entry is originally from NCBI GenBank Y18523.4.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000691
Short description acarbose biosynthetic gene cluster from Actinoplanes sp. SE50/110
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Saccharide
Loci NCBI GenBank: Y18523.4
Compounds
  • acarbose
Species Actinoplanes sp. SE50/110 [taxonomy]
References
Chemical products information
acarbose
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C25H43N1O18
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAJ81017.1
  • asp.3.3
 1 - 1206 (-) hypothetical protein
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  • CAJ81018.1
  • acbZ
 1728 - 5039 (+) alpha-amylase AcbZ
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  • CAJ81019.1
  • acbY
 5104 - 5907 (-) ABC transporter permease protein AcbY
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  • CAJ81020.1
  • acbX
 5904 - 6707 (-) ABC transporter permease protein AcbX
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  • CAJ81021.1
  • acbW
 6704 - 7777 (-) ABC transporter ATP-binding protein AcbW
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  • CAJ81022.1
  • acbV
 8551 - 9912 (+) dTDP-4-keto-6-deoxy-glucose 4-aminotransferase AcbV
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  • CAJ81023.1
  • acbU
 9909 - 11387 (+) putative kinase (1-epi-valienol-7-phosphate 1-kinase) AcbU
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  • CAJ81024.1
  • acbS
 11392 - 13521 (+) glycosyltransferase AcbS
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  • CAJ81025.1
  • acbR
 13518 - 14609 (+) putative 1-epi-valienol-1,7-bisphosphate-1-adenylyltransferase AcbR
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  • CAJ81026.1
  • acbP
 14606 - 15193 (+) putative NUDIX hydrolase AcbP
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  • CAJ81027.1
  • acbI
 15181 - 17385 (+) glycosyltransferase AcbI
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  • CAJ81028.1
  • acbJ
 17387 - 18238 (+) putative hydrolase AcbJ
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  • CAJ81029.1
  • acbQ
 18235 - 20331 (+) putative acarbose 4-alpha-glucanotransferase AcbQ
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  • CAD29481.2
  • acbK
 20363 - 21262 (+) acarbose 7-kinase AcbK
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  • CAD29482.2
  • acbM
 21259 - 22338 (+) 2-epi-5-epi-valiolone 7-kinase AcbM
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  • CAD29483.2
  • acbL
 22335 - 23435 (+) cyclitol dehydrogenase AcbL
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  • CAD29484.1
  • acbN
 23432 - 24187 (+) cyclitol oxidoreductase AcbN
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  • CAD29485.2
  • acbO
 24184 - 24996 (+) 2-epi-5-epi-valiolone-7-phosphate 2-epimerase AcbO
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  • CAA77208.2
  • acbC
 24993 - 26147 (+) 2-epi-5-epi-valiolone synthase AcbC
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  • CAA77209.2
  • acbB
 26253 - 27215 (-) dTDP-glucose 4,6-dehydratase AcbB
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  • CAA77210.2
  • acbA
 27298 - 28209 (+) dTDP-glucose synthase AcbA
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  • CAJ81030.1
  • acbE
 28302 - 31418 (-) acarbose resistent alpha-amylase AcbE
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  • CAJ81031.1
  • acbD
 31744 - 33918 (+) acarviose transferase (ATase) AcbD
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  • CAJ81032.1
  • acbG
 34153 - 34944 (-) ABC transporter membrane protein AcbG
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  • CAJ81033.1
  • acbF
 34995 - 35975 (-) ABC transporter membrane protein AcbF
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  • CAJ81034.1
  • AcbH
 35975 - 37276 (-) ABC transporter binding protein AcbH
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  • CAJ81035.1
  • asp3.1
 37518 - 39875 (+) putative galactocerebrosidase
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  • CAJ81036.1
  • asp3.2
 39872 - 40936 (+) putative xylanase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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