BGC0000705: kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 41,576 nt. (total: 41,576 nt).
This entry is originally from NCBI GenBank AJ628422.2.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000705
Short description kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Saccharide
Loci NCBI GenBank: AJ628422.2
Compounds
  • kanamycin
Species Streptomyces kanamyceticus [taxonomy]
References
Chemical products information
kanamycin
Copy SMILES
C18H36N4O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAF31568.1
 2 - 1555 (+) putative sugar ABC transporter
copy AA seq
copy Nt seq
  • CAF31569.1
 1564 - 2805 (+) putative sugar ABC transporter
copy AA seq
copy Nt seq
  • CAF31570.1
 3025 - 3999 (-) putative O-methyltransferase
copy AA seq
copy Nt seq
  • CAF31571.1
 4325 - 5161 (+) putative NH3-dependent NAD(+) synthase
copy AA seq
copy Nt seq
  • CAF31572.1
 5227 - 5655 (-) hypothetical protein
copy AA seq
copy Nt seq
  • CAF31573.1
 5763 - 6485 (-) hypothetical protein
copy AA seq
copy Nt seq
  • CAF31574.1
  • kaoA
 6680 - 9178 (-) possible kanamycin regulatory protein
copy AA seq
copy Nt seq
  • CAF31575.1
  • kanZ
 9320 - 11755 (-) putative kanamycin efflux protein
copy AA seq
copy Nt seq
  • CAF31576.1
  • kanY
 11959 - 12402 (-) KanY
copy AA seq
copy Nt seq
  • CAF31577.1
  • kanX
 12524 - 13786 (-) putative integral membrane kanamycin efflux protein
copy AA seq
copy Nt seq
  • CAF31578.1
  • kanW
 13837 - 14031 (-) possible kanamycin biosynthetic protein
copy AA seq
copy Nt seq
  • CAF31579.1
  • kanA
 14067 - 14597 (+) kanamycin 6'-acetyltransferase
copy AA seq
copy Nt seq
  • CAF31580.1
  • kanG
 14663 - 15784 (-) KanG
copy AA seq
copy Nt seq
  • CAF31581.1
  • kanH
 15831 - 16418 (-) KanH
copy AA seq
copy Nt seq
  • CAF31582.1
  • kanI
 16476 - 16958 (-) KanI
copy AA seq
copy Nt seq
  • CAF31583.1
  • kanR
 17386 - 18495 (+) putative regulator of gene expression
copy AA seq
copy Nt seq
  • CAF31584.1
  • kanE
 18590 - 19621 (+) 3-amino-2,3-dideoxy-scyllo-inositol 1-dehydrogenase
copy AA seq
copy Nt seq
  • CAF31585.1
  • kanT
 19720 - 20961 (+) putative kanamycin export protein
copy AA seq
copy Nt seq
  • CAF31586.1
  • kanB
 20967 - 22145 (+) pyridoxalphosphate-dependent aminotransferase class III
copy AA seq
copy Nt seq
  • CAF31587.1
  • kanQ
 22153 - 23679 (+) oxidoreductase; putative kanamycin 6'-dehydrogenase
copy AA seq
copy Nt seq
  • CAF31588.1
  • kanS1
 23798 - 25081 (+) L-glutamine:2-deoxy-ketocyclitol aminotransferase
copy AA seq
copy Nt seq
  • CAF31589.1
  • kanC
 25123 - 26295 (+) 2-deoxy scyllo-inosose synthase
copy AA seq
copy Nt seq
  • CAF31590.1
  • kanD2
 26304 - 27413 (+) oxidoreductase
copy AA seq
copy Nt seq
  • CAF31591.1
  • kanM2
 27652 - 28818 (+) putative paromamine 6-glucosyltransferase
copy AA seq
copy Nt seq
  • CAF31592.1
  • kanN
 28815 - 29564 (+) KanN
copy AA seq
copy Nt seq
  • CAF31593.1
  • kanS2
 29561 - 30820 (+) putative pyridoxalphosphate-dependent aminotransferase class IV
copy AA seq
copy Nt seq
  • CAF31594.2
  • kanJ
 30979 - 31836 (+) putative kanamycin biosynthetic protein
copy AA seq
copy Nt seq
  • CAF31595.1
  • kanK
 31970 - 32920 (+) putative (NDP-)sugar oxidoreductase
copy AA seq
copy Nt seq
  • CAF31596.1
  • kmr
 33046 - 33879 (+) 16S rRNA methyltransferasease
copy AA seq
copy Nt seq
  • CAF31597.1
  • kanM1
 33962 - 35206 (+) putative 2-deoxystreptamine 4-(N-acetyl-)glucosaminyltransferase
copy AA seq
copy Nt seq
  • CAF31598.1
  • kanL
 35265 - 36272 (+) putative kanamycin biosynthetic protein
copy AA seq
copy Nt seq
  • CAF31599.1
  • kanO
 36307 - 36705 (+) putative kanamycin biosynthetic protein
copy AA seq
copy Nt seq
  • CAF31600.1
  • kanP
 36729 - 37400 (-) putative kanamycin biosynthetic protein
copy AA seq
copy Nt seq
  • CAF31601.1
  • kanD3
 37653 - 39434 (+) putative dehydrogenase
copy AA seq
copy Nt seq
  • CAF31602.1
  • kanU
 39547 - 40356 (+) putative regulatory protein
copy AA seq
copy Nt seq
  • CAI96521.1
 40758 - >41573 (+) putative crotony-CoA reductase
copy AA seq
copy Nt seq
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.