BGC0000816: malbrancheamide A biosynthetic gene cluster from Malbranchea aurantiaca
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Location: 1 - 20,179 nt. (total: 20,179 nt).
This entry is originally from NCBI GenBank JQ708193.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000816
Short description malbrancheamide A biosynthetic gene cluster from Malbranchea aurantiaca
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Alkaloid (Pyrrole/pyrrolidine)
Loci NCBI GenBank: JQ708193.1
Compounds
  • malbrancheamide A
Species Malbranchea aurantiaca [taxonomy]
References
Chemical products information
malbrancheamide A
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C21H24Cl1N3O1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGA37261.1
  • malA
 1 - 2004 (-) flavin-dependent halogenase
  • Tailoring (Halogenation)
Sequence-based prediction
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  • AGA37262.1
  • malB
 3054 - 4163 (+) prenyltransferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AGA37263.1
  • malC
 4886 - 5680 (+) short chain dehydrogenase
  • Tailoring (Unknown)
Sequence-based prediction
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  • AGA37264.1
  • malD
 5937 - 7270 (-) negative regulator
  • Regulation
Sequence-based prediction
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  • AGA37265.1
  • malE
 8047 - 9459 (+) prenyltransferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AGA37266.1
  • malF
 10457 - 12368 (-) oxidoreductase
  • Tailoring (Unknown)
Sequence-based prediction
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  • AGA37267.1
  • malG
 13142 - 20179 (+) NRPS
  • Scaffold biosynthesis
Sequence-based prediction
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NRP-specific information
Subclass N/A
Cyclic? yes
Release type
  • Reductive release
NRP-synthases
Gene Modules
malG
Module 0
Specificity: proline
Evidence for specificity:
  • Structure-based inference
Module 1
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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