BGC0000826: staurosporine biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
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Location: 1,200,116 - 1,226,201 nt. (total: 26,086 nt).
This entry is originally from NCBI GenBank CM000914.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000826
Short description staurosporine biosynthetic gene cluster from Streptomyces clavuligerus ATCC 27064
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Alkaloid
Loci NCBI GenBank: CM000914.1
Compounds
  • staurosporine
Species Streptomyces clavuligerus ATCC 27064 [taxonomy]
References
Chemical products information
staurosporine
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C28H26N4O3
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SCLAV_p1107
  • EFG04593.1
 1200116 - 1201288 (-) Transcriptional regulator
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  • SCLAV_p1108
  • EFG04594.1
  • staC
 1201439 - 1203088 (-) Staurosporine biosynthesis monooxygenase StaC
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  • SCLAV_p1109
  • EFG04595.1
  • staMB
 1203190 - 1204065 (-) Staurosporine biosynthesis methyltransferase StaMB
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  • SCLAV_p1110
  • EFG04596.1
  • staE
 1204062 - 1204763 (-) Staurosporine biosynthesis 3,5-epimerase StaE
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  • SCLAV_p1111
  • EFG04597.1
  • staI
 1204835 - 1205944 (-) Staurosporine biosynthesis aminotransferase StaI
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  • SCLAV_p1112
  • EFG04598.1
  • staK
 1206008 - 1207015 (-) Staurosporine biosynthesis 4-ketoreductase StaK
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  • SCLAV_p1113
  • EFG04599.1
  • staJ
 1207017 - 1208675 (-) Staurosporine biosynthesis 2,3-dehydratase StaJ
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  • SCLAV_p1114
  • EFG04600.1
  • staMA
 1208787 - 1209686 (-) Staurosporine biosynthesis methyltransferase StaMA
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  • SCLAV_p1115
  • EFG04601.1
  • staP
 1209712 - 1211157 (-) Staurosporine biosynthesis cytochrome P450 StaP
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  • SCLAV_p1116
  • EFG04602.1
  • staD
 1211285 - 1214902 (-) Staurosporine biosynthesis chromopyrrolic acid synthase StaD
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  • SCLAV_p1117
  • EFG04603.1
  • staO
 1214994 - 1217036 (-) Staurosporine biosynthesis L-amino acid oxidase StaO
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  • SCLAV_p1118
  • EFG04604.1
  • staG
 1217039 - 1218346 (+) Staurosporine biosynthesis N-glycosyltransferase StaG
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  • SCLAV_p1119
  • EFG04605.1
  • staN
 1218343 - 1219746 (+) Staurosporine biosynthesis Cytochrome P450 StaN
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  • SCLAV_p1120
  • EFG04606.1
  • staA
 1219805 - 1220971 (+) Staurosporine biosynthesis glucose-1-phosphate thymidyltransferase StaA
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  • SCLAV_p1121
  • EFG04607.1
  • staB
 1220968 - 1221942 (+) Staurosporine biosynthesis dTDP-glucose 4,6-dehydratase StaB
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  • SCLAV_p1122
  • EFG04608.1
  • staR
 1221932 - 1225210 (-) Staurosporine biosynthesis transcriptional activator StaR
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  • SCLAV_p1123
  • EFG04609.1
 1225314 - 1226201 (-) Putative methyltransferase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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