BGC0000842: carbapenem MM4550 biosynthetic gene cluster from Streptomyces argenteolus
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Location: 1 - 43,761 nt. (total: 43,761 nt).
This entry is originally from NCBI GenBank KF042303.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000842
Short description carbapenem MM4550 biosynthetic gene cluster from Streptomyces argenteolus
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "UV spectrometry was used as further evidence that cabapenem MM 4550 was in fact the product of the BGC in question. Structure was drawn in chemdraw. Other cabapenem compounds are produced by orthologous genes in other Streptomycin species, but cabapenem MM 4550 is the only secondary metabolite product of this BGC."
Biosynthetic class(es)
  • Other (Non-NRP beta-lactam)
Loci NCBI GenBank: KF042303.1
Compounds
  • carbapenem MM4550
Species Streptomyces argenteolus [taxonomy]
References
Chemical products information
carbapenem MM4550
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C13H18N2O9S2
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGU42409.1
 991 - 1668 (-) hypothetical protein
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  • AGU42410.1
 3166 - 4593 (+) arabinofuranosidase
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  • AGU42411.1
  • cmmSu
 5660 - 6700 (-) CmmSu
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  • AGU42412.1
  • cmmE
 6867 - 7715 (+) CmmE
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  • AGU42413.1
  • cmmF
 7747 - 8763 (-) CmmF
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  • AGU42414.1
  • cmmG
 8760 - 9551 (-) CmmG
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  • AGU42415.1
  • cmmH
 9784 - 10473 (+) CmmH
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  • AGU42416.1
  • cmmI
 10448 - 11848 (-) CmmI
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  • AGU42418.1
  • cmmJ
 11969 - 13432 (-) CmmJ
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  • AGU42417.1
  • cmmK
 13429 - 15471 (-) CmmK
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  • AGU42419.1
  • cmmL
 15553 - 16725 (-) CmmL
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  • AGU42420.1
  • cmmM
 16958 - 18337 (-) CmmM
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  • AGU42421.1
  • cmmN
 18339 - 19448 (-) CmmN
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  • AGU42422.1
  • cmmO
 19484 - 20887 (-) CmmO
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  • AGU42423.1
  • cmmP
 20884 - 22332 (-) CmmP
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  • AGU42424.1
  • cmmQ
 22757 - 23536 (+) CmmQ
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  • AGU42425.1
  • cmm17
 23533 - 24411 (+) Cmm17
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  • AGU42426.1
  • cmmR
 24387 - 25073 (-) CmmR
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  • AGU42427.1
  • cmmT
 25228 - 26394 (+) CmmT
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  • AGU42428.1
  • cmmS
 26387 - 27391 (-) CmmS
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  • AGU42429.1
  • cmmPah
 27704 - 28600 (+) CmmPah
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  • AGU42430.1
  • cmm22
 29339 - 30022 (+) Cmm22
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  • AGU42431.1
  • cmm23
 30019 - 31545 (+) Cmm23
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  • AGU42432.1
  • cmm24
 31482 - 32195 (+) Cmm24
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  • AGU42433.1
  • orf25
 32511 - 35795 (-) Orf25
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  • AGU42434.1
  • orf26
 36860 - 39949 (+) Orf26
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  • AGU42435.1
  • orf27
 40883 - 41767 (-) Orf27
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  • AGU42436.1
  • orf28
 42033 - 43220 (+) Orf28
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  • AGU42437.1
  • orf29
 43246 - 43743 (-) Orf29
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Added compound information, update loci
3.0
  • Hidden contributor (ID: H5KVDLSVQ3TJW7SKCDNBDEVC, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for carbapenem MM4550
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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