BGC0000922: 2-heptyl-3-hydroxy-4-quinolone biosynthetic gene cluster from Pseudomonas aeruginosa PAO1
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Location: 1,073,960 - 1,087,095 nt. (total: 13,136 nt).
This entry is originally from NCBI GenBank AE004091.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
Tailoring
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000922
Short description 2-heptyl-3-hydroxy-4-quinolone biosynthetic gene cluster from Pseudomonas aeruginosa PAO1
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type III)
Loci
AE004091.2
1073960 - 1087095
via
Compounds
  • 2-heptyl-3-hydroxy-4-quinolone
  • 2,4-Quinolinediol
  • 2-heptylquinolin-4(1H)-one
Species Pseudomonas aeruginosa PAO1 [taxonomy]
References
Chemical products information
2-heptyl-3-hydroxy-4-quinolone [synonyms: Pseudomonas quinolone signal, PQS] Evidence: Experimental values match with authentic standard [3]
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C16H21N1O2
Chemical database entries
NPAtlas
2,4-Quinolinediol [synonyms: 4-Dihydroxyquinoline, 2] Evidence: Experimental values match with authentic standard [2]
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C9H7N1O2
Chemical database entries
PubCHEM
2-heptylquinolin-4(1H)-one [synonyms: 2-heptyl-4-quinolone, HHQ] Evidence: Mass spectrometry [1]
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C16H21N1O1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PA0993
  • AAG04382.1
  • cupC2
 1073960 - 1074673 (+) chaperone CupC2
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    • PA0994
    • AAG04383.1
    • cupC3
    		 1074784 - 1077303 (+) usher CupC3
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      • PA0995
      • AAG04384.1
      • ogt
      		 1077383 - 1077904 (-) methylated-DNA--protein-cysteine methyltransferase
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        • PA0996
        • AAG04385.1
        • pqsA
        		 1078462 - 1080015 (+) probable coenzyme A ligase
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          • PA0997
          • AAG04386.1
          • pqsB
          		 1080009 - 1080860 (+) PqsB
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            • PA0998
            • AAG04387.1
            • pqsC
            		 1080853 - 1081899 (+) PqsC
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              • PA0999
              • AAG04388.1
              • pqsD
              		 1081942 - 1082955 (+) 3-oxoacyl-[acyl-carrier-protein] synthase III
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                • PA1000
                • AAG04389.1
                • pqsE
                		 1082949 - 1083854 (+) Quinolone signal response protein
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                  • PA1001
                  • AAG04390.1
                  • phnA
                  		 1083972 - 1085564 (+) anthranilate synthase component I
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                    • PA1002
                    • AAG04391.1
                    • phnB
                    		 1085542 - 1086144 (+) anthranilate synthase component II
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                      • PA1003
                      • AAG04392.1
                      • mvfR
                      		 1086097 - 1087095 (-) Transcriptional regulator MvfR
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                        Biosynthesis information

                        No biosynthesis information available for this record.

                        Annotation changelog

                        Entry version: 5

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2024-04-23
                        MIBiG v4 annotathon
                        • (ID: BRS25WBFDJIPJGRFVYTEPI2R)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 4

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Update chemical activity to schema version 2.11
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 3

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Updated bioactivity data
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2019-10-16
                        Migrated from v1.4
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2015-06-12
                        Submitted
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        Tailoring functions
                        Tailoring enzymes detected in this region
                        Hydrolases: hydrolase
                        PA1000: metallo-beta-lactamase family protein
                        smcogs
                        SMCOG1170: metallo-beta-lactamase family protein
                        Isomerases: isomerase
                        PA1001: isochorismate synthase
                        smcogs
                        SMCOG1018: isochorismate synthase
                        Ligases: ligase synthase
                        PA0996: AMP-dependent synthetase and ligase
                        smcogs
                        SMCOG1002: AMP-dependent synthetase and ligase
                        PA0998: 3-oxoacyl-(acyl carrier protein) synthase III
                        smcogs
                        SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III
                        PA0999: 3-oxoacyl-(acyl carrier protein) synthase III
                        smcogs
                        SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III
                        PA1002: carbamoyl phosphate synthase small subunit
                        smcogs
                        SMCOG1249: carbamoyl phosphate synthase small subunit
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