BGC0000951: pacidamycin 1 biosynthetic gene cluster from Streptomyces coeruleorubidus
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Location: 1 - 30,311 nt. (total: 30,311 nt).
This entry is originally from NCBI GenBank HM855229.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000951
Short description pacidamycin 1 biosynthetic gene cluster from Streptomyces coeruleorubidus
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: HM855229.1
Compounds
  • pacidamycin 1
  • pacidamycin 2
  • pacidamycin 3
  • pacidamycin 4
  • pacidamycin 5
  • pacidamycin 6
  • pacidamycin 7
  • pacidamycin D
Species Streptomyces coeruleorubidus [taxonomy]
References
Chemical products information
pacidamycin 1
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C41H50N10O12
pacidamycin 2
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C39H49N9O12
pacidamycin 3
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C39H49N9O13
pacidamycin 4
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C38H45N9O11
pacidamycin 5
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C36H44N8O11
pacidamycin 6
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C40H48N10O12
pacidamycin 7
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C38H47N9O12
pacidamycin D
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C32H41N9O10
Chemical database entries
NPAtlas
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADN26237.1
  • pacA
 1 - 777 (+) hypothetical protein
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  • ADN26238.1
  • pacB
 843 - 1700 (-) hypothetical protein
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  • ADN26239.1
  • pacC
 2161 - 3312 (-) major facilitator transporter
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  • ADN26240.1
  • pacD
 3708 - 4904 (+) condensation superfamily
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  • ADN26241.1
  • pacE
 4939 - 6219 (+) PLP-dependent aminotransferase
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  • ADN26242.1
  • pacF
 6355 - 7290 (+) Fe(II)/ 2-oxoglutarate-dependent oxygenase
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  • ADN26243.1
  • pacG
 7407 - 8141 (+) hypothetical protein
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  • ADN26244.1
  • pacH
 8373 - 8654 (+) thiolation domain
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  • ADN26245.1
  • pacI
 8651 - 9922 (+) condensation superfamily
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  • ADN26246.1
  • pacJ
 10125 - 10343 (+) MbtH domain-containing protein
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  • ADN26247.1
  • pacK
 10508 - 11839 (+) FAD-dependent oxidoreductase
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  • ADN26248.1
  • pacL
 11961 - 14510 (-) peptide synthetase
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  • ADN26249.1
  • pacM
 14605 - 14970 (-) putative cupin_2 domain-containing isomerase
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  • ADN26250.1
  • pacN
 14988 - 16712 (-) peptide synthetase
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  • ADN26251.1
  • pacO
 17292 - 18875 (+) ATP-dependent adenylase
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  • ADN26252.1
  • pacP
 19411 - 21957 (+) peptide synthetase
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  • ADN26253.1
  • pacQ
 21954 - 23450 (+) argininosuccinate lyase
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  • ADN26254.1
  • pacR
 23447 - 24403 (+) putative kinase
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  • ADN26255.1
  • pacS
 24390 - 26657 (+) fusion protein containing a PLP-dependent cysteine synthase and an argininosuccinate lyase
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  • ADN26256.1
  • pacT
 26675 - 27727 (+) PLP-dependent threonine aldolase
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  • ADN26257.1
  • pacU
 27891 - 29414 (+) ATP-dependent adenylase
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  • ADN26258.1
  • pacV
 29559 - 30311 (+) SAM-dependent methyltransferase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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