BGC0000951: pacidamycin 1 biosynthetic gene cluster from Streptomyces coeruleorubidus
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Location: 1 - 30,311 nt. (total: 30,311 nt).
This entry is originally from NCBI GenBank HM855229.1.

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core biosynthetic genes
additional biosynthetic genes
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General
Compounds
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000951
Short description pacidamycin 1 biosynthetic gene cluster from Streptomyces coeruleorubidus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
HM855229.1
via
Compounds
  • pacidamycin 1
  • pacidamycin 2
  • pacidamycin 3
  • pacidamycin 4
  • pacidamycin 5
  • pacidamycin 6
  • pacidamycin 7
  • pacidamycin D
Species Streptomyces coeruleorubidus [taxonomy]
References
Chemical products information
pacidamycin 1 Evidence:
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C41H50N10O12
pacidamycin 2 Evidence:
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C39H49N9O12
pacidamycin 3 Evidence:
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C39H49N9O13
pacidamycin 4 Evidence:
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C38H45N9O11
pacidamycin 5 Evidence:
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C36H44N8O11
pacidamycin 6 Evidence:
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C40H48N10O12
pacidamycin 7 Evidence:
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C38H47N9O12
pacidamycin D Evidence:
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C32H41N9O10
Chemical database entries
NPAtlas
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADN26237.1
  • pacA
 1 - 777 (+) hypothetical protein
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    • ADN26238.1
    • pacB
    		 843 - 1700 (-) hypothetical protein
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      • ADN26239.1
      • pacC
      		 2161 - 3312 (-) major facilitator transporter
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        • ADN26240.1
        • pacD
        		 3708 - 4904 (+) condensation superfamily
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          • ADN26241.1
          • pacE
          		 4939 - 6219 (+) PLP-dependent aminotransferase
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            • ADN26242.1
            • pacF
            		 6355 - 7290 (+) Fe(II)/ 2-oxoglutarate-dependent oxygenase
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              • ADN26243.1
              • pacG
              		 7407 - 8141 (+) hypothetical protein
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                • ADN26244.1
                • pacH
                		 8373 - 8654 (+) thiolation domain
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                  • ADN26245.1
                  • pacI
                  		 8651 - 9922 (+) condensation superfamily
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                    • ADN26246.1
                    • pacJ
                    		 10125 - 10343 (+) MbtH domain-containing protein
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                      • ADN26247.1
                      • pacK
                      		 10508 - 11839 (+) FAD-dependent oxidoreductase
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                        • ADN26248.1
                        • pacL
                        		 11961 - 14510 (-) peptide synthetase
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                          • ADN26249.1
                          • pacM
                          		 14605 - 14970 (-) putative cupin_2 domain-containing isomerase
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                            • ADN26250.1
                            • pacN
                            		 14988 - 16712 (-) peptide synthetase
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                              • ADN26251.1
                              • pacO
                              		 17292 - 18875 (+) ATP-dependent adenylase
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                                • ADN26252.1
                                • pacP
                                		 19411 - 21957 (+) peptide synthetase
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                                  • ADN26253.1
                                  • pacQ
                                  		 21954 - 23450 (+) argininosuccinate lyase
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                                    • ADN26254.1
                                    • pacR
                                    		 23447 - 24403 (+) putative kinase
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                                      • ADN26255.1
                                      • pacS
                                      		 24390 - 26657 (+) fusion protein containing a PLP-dependent cysteine synthase and an argininosuccinate lyase
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                                        • ADN26256.1
                                        • pacT
                                        		 26675 - 27727 (+) PLP-dependent threonine aldolase
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                                          • ADN26257.1
                                          • pacU
                                          		 27891 - 29414 (+) ATP-dependent adenylase
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                                            • ADN26258.1
                                            • pacV
                                            		 29559 - 30311 (+) SAM-dependent methyltransferase
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                                              Biosynthesis information
                                              Annotation changelog

                                              Entry version: 4

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-10-07
                                              Update chemical activity to schema version 2.11
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 3

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-09-15
                                              Updated bioactivity data
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 2

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2019-10-16
                                              Migrated from v1.4
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2019-10-16
                                              Updated compound(s) information (MIBiG Annotathon)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2019-10-16
                                              Updated compound(s) information (NPAtlas curation)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 1

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2015-06-12
                                              Submitted
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              Detailed domain annotation
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