BGC0000955: althiomycin biosynthetic gene cluster from Myxococcus xanthus
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Location: 1 - 33,020 nt. (total: 33,020 nt).
This entry is originally from NCBI GenBank FR831800.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000955
Short description althiomycin biosynthetic gene cluster from Myxococcus xanthus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: FR831800.1
Compounds
  • althiomycin
Species Myxococcus xanthus [taxonomy]
References
Chemical products information
althiomycin [synonyms: matamycin]
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C16H17N5O6S2
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCA29199.1
  • almE
 730 - 2067 (+) drug resistance transporter
  • Transport
Other in vivo study
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  • CCA29200.1
  • almD
 2191 - 3186 (+) N-oxygenase
  • Tailoring (Oxidation)
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  • CCA29201.1
  • almC
 3216 - 4121 (+) SAM-dependent methyltransferase
  • Tailoring (Methylation)
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  • CCA29202.1
  • almA
 4229 - 11416 (+) non-ribosomal peptide synthetase
  • Scaffold biosynthesis
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  • CCA29203.1
  • almB
 11416 - 27699 (+) non-ribosomal peptide synthetase/polyketide synthase
  • Scaffold biosynthesis
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  • CCA29204.1
  • almF
 27699 - 28664 (+) putative type-II thioesterase
  • Activation / processing
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Polyketide-specific information
Subclass Other
Cyclic? no
Polyketide-synthases
Genes Properties Modules
almB Synthase subclass: Modular type I
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: almB
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? no
Thioesterase genes
  • almB (Unknown)
NRP-synthases
Gene Modules
almA
Module 0
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Starter
Module 1
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Heterocyclization
Modification domains: Oxidation
almB
Module 2
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 3
Specificity: cysteine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Heterocyclization
Modification domains: Oxidation
Module 4
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: DCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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