BGC0000959: aspyridone A biosynthetic gene cluster from Aspergillus nidulans FGSC A4
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Location: 383,588 - 417,319 nt. (total: 33,732 nt).
This entry is originally from NCBI GenBank BN001305.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000959
Short description aspyridone A biosynthetic gene cluster from Aspergillus nidulans FGSC A4
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: BN001305.1
Compounds
  • aspyridone A
  • aspyridone B
Species Aspergillus nidulans FGSC A4 [taxonomy]
References
Chemical products information
aspyridone A
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C19H23N1O4
Chemical database entries
PubCHEM
aspyridone B
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C19H23N1O5
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ANIA_08408
  • CBF80479.1
 383588 - 385551 (-) Cytochrome P450 monooxygenase (Eurofung)
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  • ANIA_08409
  • CBF80481.1
 385918 - 387078 (+) enoylreductase
  • Scaffold biosynthesis
Activity assay
Heterologous expression
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  • ANIA_08410
  • CBF80483.1
 387281 - 389445 (+) FAD-dependent monooxygenase (Eurofung)
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  • ANIA_08411
  • CBF80485.1
 390561 - 392240 (-) PKS-NRPS hybrid
  • Scaffold biosynthesis
Activity assay
Heterologous expression
Other in vivo study
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  • ANIA_08412
  • CBF80487.1
 392716 - 404651 (+) hybrid PKS-NRPS (Eurofung)
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  • ANIA_08413
  • CBF80489.1
 404935 - 407139 (-) Exporter (Eurofung)
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  • ANIA_08414
  • CBF80491.1
 407965 - 410253 (+) Putative Zn(II)2Cys6 transcription factor (Eurofung)
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  • ANIA_11608
  • CBF80493.1
 412393 - 412551 (-) hypothetical protein
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  • ANIA_08415
  • CBF80495.1
 415926 - 417319 (+) Acyl-CoA dehydrogenase (Eurofung)
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
ANIA_08412 Synthase subclass: Iterative type I
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 3
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
ANIA_08412
Module 1
Specificity: tyrosine / phenylalanine / tryptophan / 4-fluorophenylalanine
Evidence for specificity:
  • Activity assay
Condensation domain type: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: ZUAEFEJPIFGA5SNZGJWBG3IU, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: H5KVDLSVQ3TJW7SKCDNBDEVC, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Add new compound: aspyridone B
  • Corrected NRP module activity
  • Corrected NRP gene names
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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