BGC0000978: cylindrospermopsin biosynthetic gene cluster from Cylindrospermopsis raciborskii AWT205
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Location: 1 - 42,156 nt. (total: 42,156 nt).
This entry is originally from NCBI GenBank EU140798.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000978
Short description cylindrospermopsin biosynthetic gene cluster from Cylindrospermopsis raciborskii AWT205
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
  • Alkaloid
Loci NCBI GenBank: EU140798.1
Compounds
  • cylindrospermopsin
Species Cylindrospermopsis raciborskii AWT205 [taxonomy]
References
Chemical products information
cylindrospermopsin
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C15H21N5O7S1
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABX60152.1
  • cyrD
 444 - 6074 (+) polyketide synthase
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  • ABX60153.1
  • cyrF
 6130 - 10203 (+) polyketide synthase
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  • ABX60154.1
  • cyrG
 10251 - 11687 (+) putative uracil ring formation
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  • ABX60155.1
  • cyrI
 11741 - 12571 (+) proline dioxygenase-like protein
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  • ABX60156.1
  • cyrK
 12568 - 13965 (-) multidrug exporter MatE
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  • ABX60157.1
  • cyrL
 14037 - 14786 (+) transposase
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  • ABX60158.1
  • cyrH
 14886 - 16316 (+) aminohydrolase
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  • ABX60159.1
  • cyrJ
 16893 - 17672 (+) putative sulfotransferase
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  • ABX60160.1
  • cyrA
 18113 - 19288 (+) amidinotransferase
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  • ABX60161.1
  • cyrB
 19303 - 28056 (+) mixed NRPS/PKS
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  • ABX60162.1
  • cyrE
 28061 - 33727 (+) polyketide synthase
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  • ABX60163.1
  • cyrC
 34299 - 39302 (+) polyketide synthase
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  • ABX60164.1
  • cyrN
 39793 - 40392 (-) adenylylsulfate kinase
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  • ABX60165.1
  • cyrO
 40501 - 42048 (+) CyrO
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Polyketide-specific information
Subclass Other
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
cyrD
+
cyrB
+
cyrC
+
cyrE
+
cyrF 		Synthase subclass: Modular type I
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: cyrD
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: cyrF
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: cyrB
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: cyrE
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: cyrC
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass N/A
Cyclic? yes
NRP-synthases
Gene Modules
cyrB
Module 0
Specificity: guanidinoacetic acid
Evidence for specificity:
  • Activity assay
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: EI7LXM427LE4WIOQ5U54V3BB, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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