BGC0000983: cytochalasin E biosynthetic gene cluster from Aspergillus clavatus NRRL 1
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Location: 334,675 - 379,692 nt. (total: 45,018 nt).
This entry is originally from NCBI GenBank DS027057.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000983
Short description cytochalasin E biosynthetic gene cluster from Aspergillus clavatus NRRL 1
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: DS027057.1
Compounds
  • cytochalasin E
  • cytochalasin K
Species Aspergillus clavatus NRRL 1 [taxonomy]
References
Chemical products information
cytochalasin E
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C28H33N1O7
Chemical database entries
NPAtlas
PubCHEM
cytochalasin K
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C32H37N1O6
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACLA_078610
  • EAW09112.1
 334675 - 338654 (+) sensor histidine kinase/response regulator, putative
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  • ACLA_078620
  • EAW09113.1
 339108 - 341077 (-) glucan 1,4-alpha-glucosidase, putative
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  • ACLA_078630
  • EAW09114.1
 342001 - 342585 (-) hypothetical protein
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  • ACLA_078640
  • EAW09115.1
 344589 - 345815 (-) transcriptional factor
  • Regulation
Other in vivo study
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  • ACLA_078650
  • EAW09116.1
 348127 - 350093 (-) cyclohexanone monooxygenase, putative
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  • ACLA_078660
  • EAW09117.1
 351008 - 363381 (-) hybrid NRPS/PKS enzyme, putative
  • Scaffold biosynthesis
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  • ACLA_078670
  • EAW09118.1
 365082 - 366679 (-) cytochrome P450 oxidoreductase GliF
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  • ACLA_078680
  • EAW09119.1
 367924 - 369304 (-) conserved hypothetical protein
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  • ACLA_078690
  • EAW09120.1
 369641 - 370831 (-) conserved hypothetical protein
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  • ACLA_078700
  • EAW09121.1
 371259 - 372412 (+) zinc-binding dehydrogenase family oxidoreductase, putative
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  • ACLA_078710
  • EAW09122.1
 372611 - 374407 (+) cytochrome P450
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  • ACLA_078720
  • EAW09123.1
 374885 - 375614 (+) thioredoxin, putative
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  • ACLA_078730
  • EAW09124.1
 376973 - 378481 (+) mannitol dehydrogenase, putative
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Reductive release
Polyketide-synthases
Genes Properties Modules
ACLA_078660 Synthase subclass: Iterative type I
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 8
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: ACLA_078660
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass N/A
Cyclic? yes
Release type
  • Reductive release
NRP-synthases
Gene Modules
ACLA_078660
Module 2
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: BMUFDHMMOLZWQLUNJMQED2GP, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Corrected gene identifiers
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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