BGC0000991: epothilone biosynthetic gene cluster from Sorangium cellulosum
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Location: 1 - 58,733 nt. (total: 58,733 nt).
This entry is originally from NCBI GenBank AF217189.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000991
Short description epothilone biosynthetic gene cluster from Sorangium cellulosum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
AF217189.1
via
Compounds
  • epothilone
Species Sorangium cellulosum [taxonomy]
References
Chemical products information
epothilone Evidence:
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C27H41N1O6S1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAF62878.1
 <5 - 992 (+) putative transposase
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    • AAF62879.1
    		 989 - 1501 (+) putative transposase
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      • AAF62880.1
      • epoA
      		 1998 - 6263 (+) EpoA
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        • AAF62881.1
        • epoB
        		 6260 - 10492 (+) EpoB
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          • AAF62882.1
          • epoC
          		 10639 - 16137 (+) EpoC
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            • AAF62883.1
            • epoD
            		 16134 - 37907 (+) epoD
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              • AAF62884.1
              • epoE
              		 37912 - 49308 (+) EpoE
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                • AAF62885.1
                • epoF
                		 49323 - 56642 (+) EpoF
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                  • AAF62886.1
                  • epoK
                  		 56757 - 58016 (+) EpoK
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                    • AAF62887.1
                    		 58194 - 58733 (+) putative membrane protein
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      Unk01
                      Type
                      nrps-type1
                      Genes
                      epoB
                      Substrates
                      cysteine (evidence: )
                      Integrated Monomers
                      Domains
                      adenylation
                      Annotation changelog

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Added NRP substrate specificities
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                      Detailed domain annotation
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