BGC0001007: lymphostin biosynthetic gene cluster from Salinispora arenicola CNS-205
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 3,781,645 - 3,805,331 nt. (total: 23,687 nt).
This entry is originally from NCBI GenBank CP000850.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001007
Short description lymphostin biosynthetic gene cluster from Salinispora arenicola CNS-205
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
  • NRP
Loci NCBI GenBank: CP000850.1
Compounds
  • lymphostin
  • neolymphostinol B
  • lymphostinol
  • neolymphostin b
Species Salinispora arenicola CNS-205 [taxonomy]
References
Chemical products information
lymphostin
Copy SMILES
C16H14N4O3
neolymphostinol B
Copy SMILES
C16H16N4O3
lymphostinol
Copy SMILES
C15H14N4O3
neolymphostin b
Copy SMILES
C17H16N4O3
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Sare_3281
  • ABV99084.1
 3781645 - 3782502 (+) Methyltransferase type 11
copy AA seq
copy Nt seq
  • Sare_3282
  • ABV99085.1
 3782559 - 3789683 (+) thioester reductase domain
copy AA seq
copy Nt seq
  • Sare_3283
  • ABV99086.1
 3789863 - 3791824 (-) asparagine synthase (glutamine-hydrolyzing)
copy AA seq
copy Nt seq
  • Sare_3284
  • ABV99087.1
 3791944 - 3793422 (+) Xaa-Pro aminopeptidase
copy AA seq
copy Nt seq
  • Sare_3285
  • ABV99088.1
 3793699 - 3795297 (+) conserved hypothetical protein
copy AA seq
copy Nt seq
  • Sare_3286
  • ABV99089.1
 3795646 - 3798168 (+) hypothetical protein
copy AA seq
copy Nt seq
  • Sare_3287
  • ABV99090.1
 3798352 - 3798945 (-) conserved hypothetical protein
copy AA seq
copy Nt seq
  • Sare_3288
  • ABV99091.1
 3798961 - 3799119 (-) hypothetical protein
copy AA seq
copy Nt seq
  • Sare_3289
  • ABV99092.1
 3799414 - 3802260 (+) aconitate hydratase 1
copy AA seq
copy Nt seq
  • Sare_3290
  • ABV99093.1
 3802447 - 3802695 (+) conserved hypothetical protein
copy AA seq
copy Nt seq
  • Sare_3291
  • ABV99094.1
 3802832 - 3803758 (-) protein of unknown function RIO1
copy AA seq
copy Nt seq
  • Sare_3292
  • ABV99095.1
 3803912 - 3804556 (-) HAD-superfamily hydrolase, subfamily IA, variant 1
copy AA seq
copy Nt seq
  • Sare_3293
  • ABV99096.1
 3804759 - 3805331 (+) transcriptional regulator, TetR family
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
Sare_3282 Synthase subclass:
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: Sare_3282
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Reductive release
NRP-synthases
Gene Modules
Sare_3282
Module 0
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: UJYWT4SZRXDY2IOPYAIF6MII, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.