BGC0001008: maduropeptin biosynthetic gene cluster from Actinomadura madurae
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Location: 5,704 - 85,411 nt. (total: 79,708 nt).
This entry is originally from NCBI GenBank AY271660.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
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General
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Biosynthesis
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KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001008
Short description maduropeptin biosynthetic gene cluster from Actinomadura madurae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Iterative type I)
Loci
AY271660.2
12362 - 75173
via
Compounds
  • maduropeptin
Species Actinomadura madurae [taxonomy]
References
Chemical products information
maduropeptin Evidence:
Copy SMILES
C24H20Cl1N1O6
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABY66030.1
  • mdpA1
 12362 - 13396 (+) dTDP-1-glucose synthase
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    • ABY66029.1
    • mdpL
    		 13466 - 14848 (-) epoxidase
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      • ABY66028.1
      • mdpC8
      		 14931 - 15953 (-) Zn-dependent alcohol dehydrogenase
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        • ABY66027.1
        • mdpA4
        		 16169 - 17389 (+) C-methyltransferase
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          • ABY66026.1
          • mdpC3
          		 17470 - 19089 (-) monooxygenase
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            • ABY66025.1
            • mdpA3
            		 19106 - 20092 (-) glucuronic acid decarboxylase
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              • ABY66024.1
              • mdpA2
              		 20095 - 21438 (-) NDP glucose dehydrogenase
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                • ABY66023.1
                • mdpA5
                		 21450 - 22661 (-) aminotransferase
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                  • ABY66022.1
                  • mdpJ
                  		 22658 - 23104 (-) unknown
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                    • ABY66021.1
                    • mdpD2
                    		 23145 - 24329 (-) oxidoreductase
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                      • ABY66020.1
                      • mdpB1
                      		 24584 - 25630 (+) C-methyltransferase
                      • Methylation
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                      • ABY66019.1
                      • mdpB
                      		 25704 - 30947 (+) 6-methylsalicylic acid synthase
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                        • ABY66018.1
                        • mdpB2
                        		 30944 - 32590 (+) CoA ligase
                        • Other
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                        • ABY66017.1
                        • mdpB3
                        		 32644 - 33501 (-) acetyltransferase/esterase
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                          • ABY66016.1
                          • mdpA6
                          		 33498 - 34898 (-) glycosyltransferase
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                            • ABY66015.1
                            • mdpR4
                            		 35059 - 35796 (+) DNA alkylation repair
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                              • ABY66014.1
                              • mdpU1
                              		 35858 - 37087 (-) P450 oxidoreductase
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                                • ABY66013.1
                                • mdpU2
                                		 37084 - 38229 (-) hypothetical protein
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                                  • ABY66012.1
                                  • mdpU3
                                  		 38243 - 39478 (-) P450 oxidoreductase
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                                    • ABY66011.1
                                    • mdpC7
                                    		 39512 - 40897 (-) aminotransferase
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                                      • ABY66010.1
                                      • mdpA
                                      		 41116 - 41619 (+) binding protein
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                                        • ABY66009.1
                                        • mdpR3
                                        		 42173 - 43750 (-) transmembrane efflux protein
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                                          • ABY66008.1
                                          • mdpH
                                          		 43877 - 45205 (-) hydroxylase
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                                            • ABY66007.1
                                            • mdpC5
                                            		 45557 - 46939 (-) type II condensation domain protein
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                                              • ABY66006.1
                                              • mdpC
                                              		 46957 - 48513 (-) halogenase
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                                                • ABY66005.1
                                                • mdpC4
                                                		 48638 - 50251 (-) MIO-containing aminomutase
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                                                  • ABY66004.1
                                                  • mdpC1
                                                  		 50248 - 53595 (-) type II beta-Tyr adenylation domain protein
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                                                    • ABY66003.1
                                                    • mdpC2
                                                    		 53809 - 54096 (+) type II PCP domain protein
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                                                      • ABY66002.1
                                                      • mdpC6
                                                      		 54160 - 54756 (-) O-methyltransferase
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                                                        • ABY66001.1
                                                        • mdpE11
                                                        		 54864 - 55667 (-) unknown
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                                                          • ABY66000.1
                                                          • mdpM
                                                          		 55742 - 56839 (-) unknown
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                                                            • ABY65999.1
                                                            • mdpE9
                                                            		 56853 - 58511 (-) oxidoreductase
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                                                              • ABY65998.1
                                                              • mdpE8
                                                              		 58508 - 59077 (-) unknown
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                                                                • ABY65997.1
                                                                • mdpR1
                                                                		 59561 - 60574 (+) regulatory protein
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                                                                  • ABY65996.1
                                                                  • mdpR2
                                                                  		 60834 - 61589 (+) transcription regulatory protein
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                                                                    • AAQ17113.2
                                                                    • mdpE7
                                                                    		 61675 - 63069 (-) putative P450 hydroxylase
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                                                                      • AAQ17112.1
                                                                      • mdpE6
                                                                      		 63066 - 63617 (-) flavin reductase
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                                                                        • AAQ17111.1
                                                                        • mdpE10
                                                                        		 63614 - 64072 (-) type II thioesterase
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                                                                          • AAQ17110.2
                                                                          • mdpE
                                                                          		 64077 - 69911 (-) enediyne polyketide synthase
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                                                                            • AAQ17109.1
                                                                            • mdpE5
                                                                            		 69908 - 70900 (-) unknown
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                                                                              • AAQ17108.2
                                                                              • mdpE4
                                                                              		 70907 - 72943 (-) unknown
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                                                                                • AAQ17107.2
                                                                                • mdpE3
                                                                                		 72947 - 73849 (-) hypothetical protein
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                                                                                  • ABY65995.1
                                                                                  • mdpE2
                                                                                  		 74178 - 75173 (-) unknown
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                                                                                    Biosynthesis information

                                                                                    No biosynthesis information available for this record.

                                                                                    Annotation changelog

                                                                                    Entry version: 5

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2024-05-06
                                                                                    MIBiG v4 annotathon
                                                                                    • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 4

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2022-10-07
                                                                                    Update chemical activity to schema version 2.11
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 3

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2022-09-15
                                                                                    Refined reference coordinates
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 2

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2019-10-16
                                                                                    Migrated from v1.4
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    2019-10-16
                                                                                    Updated compound(s) information (NPAtlas curation)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 1

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2015-06-12
                                                                                    Submitted
                                                                                    • (ID: E2T2HCM4X7QXVS4LL4JVBPPK)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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