BGC0001033: paenilamicin biosynthetic gene cluster from Paenibacillus larvae subsp. larvae DSM 25430
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Location: 1,729,923 - 1,788,675 nt. (total: 58,753 nt).
This entry is originally from NCBI GenBank CP003355.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001033
Short description paenilamicin biosynthetic gene cluster from Paenibacillus larvae subsp. larvae DSM 25430
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: CP003355.1
Compounds
  • paenilamicin
  • paenilamicin A2
  • paenilamicin B1
  • paenilamicin B2
Species Paenibacillus larvae subsp. larvae DSM 25430 [taxonomy]
References
Chemical products information
paenilamicin
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C43H88N14O13
paenilamicin A2
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C42H86N14O13
paenilamicin B1
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C43H88N16O13
paenilamicin B2
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C42H86N16O13
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ERIC2_c18040
  • AHD05614.1
 1729923 - 1737689 (+) putative non-ribosomal peptide ligase/ polyketide synthase hybrid
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  • ERIC2_c18050
  • AHD05615.1
 1737728 - 1746766 (+) putative non-ribosomal peptide ligase/ polyketide synthase hybrid
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  • ERIC2_c18060
  • AHD05616.1
 1746763 - 1752078 (+) putative non-ribosomal peptide ligase domain protein
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  • ERIC2_c18070
  • AHD05617.1
 1752098 - 1756096 (+) putative non-ribosomal peptide ligase domain protein
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  • ERIC2_c18080
  • AHD05618.1
 1756143 - 1759442 (+) putative non-ribosomal peptide ligase domain protein
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  • ERIC2_c18090
  • AHD05619.1
 1759625 - 1764208 (+) putative polyketide synthase subunit
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  • ERIC2_c18100
  • AHD05620.1
 1764209 - 1769791 (+) putative polyketide synthase subunit
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  • ERIC2_c18110
  • AHD05621.1
 1769806 - 1778028 (+) non-ribosomal peptide ligase domain protein
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  • ERIC2_c18120
  • AHD05622.1
 1778104 - 1778985 (+) hypothetical protein
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  • ERIC2_c18130
  • AHD05623.1
 1778996 - 1782103 (+) cyclic peptide transporter
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  • ERIC2_c18140
  • AHD05624.1
 1782135 - 1782992 (+) 3-hydroxybutyryl-CoA dehydrogenase
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  • ERIC2_c18150
  • AHD05625.1
 1783021 - 1783290 (+) phosphopantetheine-binding protein
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  • ERIC2_c18160
  • AHD05626.1
  • nusG1
 1783305 - 1783835 (-) transcription antitermination protein NusG
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  • ERIC2_c18170
  • AHD05627.1
 1784182 - 1788675 (+) putative non-ribosomal peptide ligase domain protein
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
ERIC2_c18040
Module ?
Specificity: lysine / arginine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
ERIC2_c18050
Module ?
Specificity: D-alanine
Evidence for specificity:
  • Structure-based inference
ERIC2_c18060
Module ?
Specificity: 2,3-diaminopropionic acid
Evidence for specificity:
  • Structure-based inference
ERIC2_c18070
Module ?
Specificity: lysine / ornithine
Evidence for specificity:
  • Structure-based inference
  • Mass spectrometry
ERIC2_c18080
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
ERIC2_c18110
Module ?
Specificity:
Evidence for specificity:
Module ?
Specificity: 2,3-diaminopropionic acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
ERIC2_c18170
Module ?
Specificity: asparagine
Evidence for specificity:
  • Sequence-based prediction
  • Homology
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Add new compound structure (SMILES) for paenilamicin
  • Add new compound: paenilamicin A2
  • Add new compound: paenilamicin B1
  • Add new compound: paenilamicin B2
  • Fixed incorrect publication
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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