BGC0001035: pneumocandin B0 biosynthetic gene cluster from Glarea lozoyensis ATCC 20868
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Location: 180,393 - 296,227 nt. (total: 115,835 nt).
This entry is originally from NCBI GenBank KE145356.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001035
Short description pneumocandin B0 biosynthetic gene cluster from Glarea lozoyensis ATCC 20868
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • NRPS (Type I)
Loci
KE145356.1
180393 - 296227
via Knock-out studies
Compounds
  • pneumocandin B0
  • pneumocandin A0
Species Glarea lozoyensis ATCC 20868 [taxonomy]
References
Chemical products information
pneumocandin B0 Evidence: NMR, Mass spectrometry
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C50H80N8O17
Chemical database entries
NPAtlas
PubCHEM
pneumocandin A0 Evidence: NMR, Mass spectrometry
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C51H82N8O17
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • GLAREA_10020
  • EPE34326.1
 180393 - 181353 (-) heterokaryon incompatibility protein
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    • GLAREA_10021
    • EPE34327.1
    		 182554 - 184500 (+) alpha/beta-Hydrolase
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      • GLAREA_10022
      • EPE34328.1
      		 185467 - 186512 (-) hypothetical protein
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        • GLAREA_10023
        • EPE34329.1
        		 188198 - 192242 (-) hypothetical protein
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          • GLAREA_10024
          • EPE34330.1
          		 192814 - 196319 (+) vWA-like protein
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            • GLAREA_10025
            • EPE34331.1
            		 197590 - 198369 (+) hypothetical protein
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              • GLAREA_10026
              • EPE34332.1
              		 199366 - 201280 (-) hypothetical protein
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                • GLAREA_10027
                • EPE34333.1
                		 203148 - 204811 (-) hypothetical protein
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                  • GLAREA_10028
                  • EPE34334.1
                  		 205415 - 206770 (+) hypothetical protein
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                    • GLAREA_10029
                    • EPE34335.1
                    		 208475 - 210659 (-) Winged helix DNA-binding protein
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                      • GLAREA_10030
                      • EPE34336.1
                      		 213690 - 215442 (-) Cytochrome P450
                      • Tailoring
                      • Knock-out
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                      • GLAREA_10031
                      • EPE34337.1
                      		 215868 - 217547 (+) Cytochrome P450
                      • Tailoring
                      • Knock-out
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                      • GLAREA_10032
                      • EPE34338.1
                      		 217962 - 218919 (+) alpha/beta-Hydrolase
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                        • GLAREA_10033
                        • EPE34339.1
                        		 219395 - 220466 (-) nonheme mononuclear iron oxygenase
                        • Tailoring
                        • Knock-out
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                        • GLAREA_10034
                        • EPE34340.1
                        		 220862 - 228891 (-) polyketide synthase
                        • Scaffold biosynthesis
                        • Knock-out
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                        • GLAREA_10035
                        • EPE34341.1
                        		 230546 - 252235 (+) non-ribosomal peptide synthetase
                        • Scaffold biosynthesis
                        • Knock-out
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                        • GLAREA_10036
                        • EPE34342.1
                        		 253841 - 258579 (+) ABC-transporter
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                          • GLAREA_10037
                          • EPE34343.1
                          		 258935 - 261970 (-) Aconitase
                          • Precursor biosynthesis
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                          • GLAREA_10038
                          • EPE34344.1
                          		 262418 - 263855 (+) Isopropylmalate dehydrogenase
                          • Precursor biosynthesis
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                          • GLAREA_10039
                          • EPE34345.1
                          		 264293 - 266317 (-) isopropyl malate synthase
                          • Precursor biosynthesis
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                          • GLAREA_10040
                          • EPE34346.1
                          		 267099 - 268369 (-) D-aminoacid aminotransferase
                          • Precursor biosynthesis
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                          • GLAREA_10041
                          • EPE34347.1
                          		 268608 - 269705 (-) nonheme mononuclear iron oxygenase
                          • Tailoring
                          • Activity assay
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                          • GLAREA_10042
                          • EPE34348.1
                          		 270159 - 271199 (+) nonheme mononuclear iron oxygenase
                          • Tailoring
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                          • GLAREA_10043
                          • EPE34349.1
                          		 271791 - 273838 (-) acyl-AMP ligase
                          • Transport
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                          • GLAREA_10044
                          • EPE34350.1
                          		 275478 - 276584 (+) nonheme mononuclear iron oxygenase
                          • Tailoring
                          • Knock-out
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                          • GLAREA_10045
                          • EPE34351.1
                          		 277253 - 279400 (-) hypothetical protein
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                            • GLAREA_10046
                            • EPE34352.1
                            		 284860 - 285558 (+) hypothetical protein
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                              • GLAREA_10047
                              • EPE34353.1
                              		 286919 - 288178 (+) hypothetical protein
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                                • GLAREA_10048
                                • EPE34354.1
                                		 288504 - 289227 (+) hypothetical protein
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                                  • GLAREA_10049
                                  • EPE34355.1
                                  		 290531 - 291572 (-) hypothetical protein
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                                    • GLAREA_10050
                                    • EPE34356.1
                                    		 293985 - 296227 (-) C2H2 and C2HC zinc finger
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      1
                                      Type
                                      pks-modular
                                      Genes
                                      GLAREA_10034
                                      Substrates
                                      Integrated Monomers
                                      Domains
                                      acyltransferase, ketosynthase, acyltransferase, dehydratase, enoylreductase, ketoreductase, methyltransferase
                                      Name
                                      2
                                      Type
                                      nrps-type1
                                      Genes
                                      GLAREA_10035
                                      Substrates
                                      4,5-dihydroxyornithine (evidence: Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      condensation (LCL), adenylation
                                      Name
                                      3
                                      Type
                                      nrps-type1
                                      Genes
                                      GLAREA_10035
                                      Substrates
                                      threonine (evidence: Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      condensation (LCL), adenylation
                                      Name
                                      4
                                      Type
                                      nrps-type1
                                      Genes
                                      GLAREA_10035
                                      Substrates
                                      4R-hydroxyproline (evidence: Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      condensation (LCL), adenylation
                                      Name
                                      5
                                      Type
                                      nrps-type1
                                      Genes
                                      GLAREA_10035
                                      Substrates
                                      3S,4S-dihydroxyhomotyrosine (evidence: Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      condensation (LCL), adenylation
                                      Name
                                      6
                                      Type
                                      nrps-type1
                                      Genes
                                      GLAREA_10035
                                      Substrates
                                      3-hydroxyglutamine (evidence: Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      condensation (LCL), adenylation
                                      Name
                                      7
                                      Type
                                      nrps-type1
                                      Genes
                                      GLAREA_10035
                                      Substrates
                                      3S-hydroxy-4S-methylproline, 3S-hydroxyproline (evidence: Structure-based inference)
                                      Integrated Monomers
                                      Domains
                                      condensation, adenylation
                                      Annotation changelog

                                      Entry version: 4

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Remove aminocoumarin BGC type
                                      • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Cleaned up synonym list
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Corrected NRP module activity
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Updated NRP substrate specificities
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2019-10-16
                                      Updated compound(s) information (NPAtlas curation)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2015-06-12
                                      Submitted
                                      • (ID: HLWXAJASFSPJVZTT5243VTF5)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      Detailed domain annotation
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