BGC0001040: rapamycin biosynthetic gene cluster from Streptomyces rapamycinicus NRRL 5491
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Location: 1 - 107,379 nt. (total: 107,379 nt).
This entry is originally from NCBI GenBank X86780.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001040
Short description rapamycin biosynthetic gene cluster from Streptomyces rapamycinicus NRRL 5491
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: X86780.1
Compounds
  • rapamycin
Species Streptomyces rapamycinicus NRRL 5491 [taxonomy]
References
Chemical products information
rapamycin
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C51H79N1O13
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAA60449.1
  • orfZZ
 1 - 871 (-) monosaccharide transporter
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  • CAA60450.1
  • orfZ
 1150 - 2319 (-)
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  • CAA60451.1
  • orfY
 2422 - 3036 (+) regulator of antibiotic transport complexes
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  • CAA60452.1
  • orfX
 3056 - 3763 (-) ABC-transporter
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  • CAA60453.1
  • orfW
 3770 - 5149 (-)
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  • CAA60454.1
  • orfV
 5184 - 6497 (-) membrane transport protein
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  • CAA60455.1
  • orfR
 6703 - 7365 (+) response regulator
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  • CAA60456.1
  • orfS
 7356 - 8555 (+) sensory protein kinase
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  • CAA60457.1
  • orfU
 8730 - 9332 (-)
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  • CAA60458.1
  • rapT
 9337 - 10131 (-) ketoreductase/dehydrogenase
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  • CAA60459.1
  • rapB
 10574 - 41245 (-) polyketide synthase
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  • CAA60460.1
  • rapA
 41242 - 66933 (-) polyketide synthase
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  • CAA60461.1
  • rapP
 67319 - 71944 (+) pipecolate incorporating enzyme
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  • CAA60462.1
  • rapC
 71949 - 90731 (+) polyketide synthase
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  • CAA60463.1
  • rapQ
 90798 - 91433 (+) methyltransferase
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  • CAA60464.1
  • rapO
 91534 - 91767 (-) ferredoxin
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  • CAA60465.1
  • rapN
 91764 - 92978 (-) cytochrome P450
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  • CAA60466.1
  • rapM
 92992 - 93945 (-) methyltransferase
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  • CAA60467.1
  • rapL
 94047 - 95078 (-) lysine cyclodeaminase
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  • CAA60468.1
  • rapK
 95430 - 96434 (+) pteridine-dependent dioxygenase
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  • CAA60469.1
  • rapJ
 96465 - 97625 (+) cytochrome P450
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  • CAA60470.1
  • rapI
 97622 - 98404 (+) methyltransferase
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  • CAA60471.1
  • orfH
 98467 - 101085 (-) regulator of cholesterol oxidase
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  • CAA60472.1
  • orfG
 101422 - 102414 (+) helix-turn-helix DNA binding protein
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  • CAA60473.1
  • orfF
 102427 - 103788 (-) membrane transport protein
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  • CAA60474.1
  • orfE
 103801 - 105198 (-)
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  • CAA60475.1
  • orfD
 105445 - 106608 (+)
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  • CAA60476.1
  • orfDD
 106758 - >107379 (+) cystathione synthase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
rapP
Module ?
Specificity: pipecolic acid
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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