BGC0001041: salinosporamide A biosynthetic gene cluster from Salinispora tropica CNB-440
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Location: 1,131,285 - 1,182,556 nt. (total: 51,272 nt).
This entry is originally from NCBI GenBank CP000667.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001041
Short description salinosporamide A biosynthetic gene cluster from Salinispora tropica CNB-440
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
CP000667.1
1140547 - 1182556
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • salinosporamide A
Species Salinispora tropica CNB-440 [taxonomy]
References
Chemical products information
salinosporamide A Evidence: NMR, X-ray crystallography
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C15H20Cl1N1O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Strop_1012
  • ABP53487.1
 1140547 - 1141836 (+) Methyltransferase type 11
  • Regulation
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  • Strop_1013
  • ABP53488.1
 1141916 - 1143271 (-) hypothetical protein
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    • Strop_1014
    • ABP53489.1
    		 1143558 - 1143890 (-) hypothetical protein
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      • Strop_1015
      • ABP53490.1
      		 1144505 - 1145353 (+) 20S proteasome, A and B subunits
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        • Strop_1017
        • ABP53491.1
        		 1145798 - 1147576 (-) dihydroxyacid dehydratase
        • Precursor biosynthesis
        • Knock-out
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        • Strop_1018
        • ABP53492.1
        		 1147560 - 1148942 (-) crotonyl-CoA reductase
        • Precursor biosynthesis
        • Knock-out Activity assay
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        • Strop_1019
        • ABP53493.1
        		 1148930 - 1149790 (-) alpha/beta hydrolase fold
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          • Strop_1020
          • ABP53494.1
          		 1149790 - 1150014 (-) MbtH domain protein
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            • Strop_1021
            • ABP53495.1
            		 1150011 - 1151288 (-) cytochrome P450
            • Tailoring
            • Knock-out
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            • Strop_1022
            • ABP53496.1
            		 1151285 - 1153078 (-) type II KS
            • Scaffold biosynthesis
            • Knock-out
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            • Strop_1023
            • ABP53497.1
            		 1153075 - 1154973 (-) NRPS (ACP-P)
            • Scaffold biosynthesis
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            • Strop_1024
            • ABP53498.1
            		 1154970 - 1161131 (-) PKS (ACP-AT-AT-KS-ACP-C)
            • Scaffold biosynthesis
            • Knock-out
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            • Strop_1025
            • ABP53499.1
            		 1161514 - 1162359 (+) hypothetical protein
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              • Strop_1026
              • ABP53500.1
              		 1162700 - 1163551 (-) 5'-CIDA synthase
              • Precursor biosynthesis
              • Knock-out
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              • Strop_1027
              • ABP53501.1
              		 1163691 - 1164458 (-) 5-CIR dehydrogenase
              • Precursor biosynthesis
              • Knock-out Activity assay
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              • Strop_1028
              • ABP53502.1
              		 1164696 - 1165475 (+) 5-CIR phosphatase
              • Precursor biosynthesis
              • Knock-out
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              • Strop_1029
              • ABP53503.1
              		 1165480 - 1166313 (+) cyclase family protein
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                • Strop_1030
                • ABP53504.1
                		 1166345 - 1167022 (-) regulatory protein, LuxR
                • Regulation
                • Knock-out Activity assay
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                • Strop_1031
                • ABP53505.1
                		 1167405 - 1170854 (+) alpha-keto decarboxylase
                • Precursor biosynthesis
                • Knock-out
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                • Strop_1032
                • ABP53506.1
                		 1171660 - 1172682 (-) regulatory protein, LysR
                • Regulation
                • Knock-out
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                • Strop_1033
                • ABP53507.1
                		 1173151 - 1173306 (+) hypothetical protein
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                  • Strop_1034
                  • ABP53508.1
                  		 1173789 - 1174244 (-) acyl dehydratase
                  • Precursor biosynthesis
                  • Knock-out
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                  • Strop_1035
                  • ABP53509.1
                  		 1174450 - 1175253 (-) 5'-CIDA phosphorylase
                  • Precursor biosynthesis
                  • Knock-out
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                  • Strop_1036
                  • ABP53510.1
                  		 1175301 - 1176692 (-) DAHP synthase
                  • Precursor biosynthesis
                  • Knock-out
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                  • Strop_1037
                  • ABP53511.1
                  		 1176969 - 1177268 (+) Stress responsive alpha-beta barrel domain protein
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                    • Strop_1038
                    • ABP53512.1
                    		 1177316 - 1178731 (+) acyl-CoA ligase
                    • Precursor biosynthesis
                    • Knock-out
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                    • Strop_1039
                    • ABP53513.1
                    		 1178731 - 1179693 (+) aminotransferase
                    • Precursor biosynthesis
                    • Knock-out
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                    • Strop_1040
                    • ABP53514.1
                    		 1179690 - 1180343 (+) prephenate decarboxylase
                    • Precursor biosynthesis
                    • Knock-out Activity assay
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                    • Strop_1041
                    • ABP53515.1
                    		 1180357 - 1181346 (+) cyclodeaminase
                    • Precursor biosynthesis
                    • Knock-out
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                    • Strop_1042
                    • ABP53516.1
                    		 1181393 - 1181686 (+) protein of unknown function DUF1330
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                      • Strop_1043
                      • ABP53517.1
                      		 1181720 - 1182556 (+) epimerase
                      • Precursor biosynthesis
                      • Knock-out
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                      Biosynthesis information

                      No biosynthesis information available for this record.

                      Annotation changelog

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: UJYWT4SZRXDY2IOPYAIF6MII)
                      • (ID: NQ4XH53U6SBHJITINA72OVAX)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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