BGC0001041: salinosporamide A biosynthetic gene cluster from Salinispora tropica CNB-440
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Location: 1,140,547 - 1,182,556 nt. (total: 42,010 nt).
This entry is originally from NCBI GenBank CP000667.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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TTA codons
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001041
Short description salinosporamide A biosynthetic gene cluster from Salinispora tropica CNB-440
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: CP000667.1
Compounds
  • salinosporamide A
Species Salinispora tropica CNB-440 [taxonomy]
References
Chemical products information
salinosporamide A
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C15H20Cl1N1O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Strop_1012
  • ABP53487.1
 1140547 - 1141836 (+) Methyltransferase type 11
  • Regulation
Sequence-based prediction
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  • Strop_1013
  • ABP53488.1
 1141916 - 1143271 (-) hypothetical protein
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  • Strop_1014
  • ABP53489.1
 1143558 - 1143890 (-) hypothetical protein
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  • Strop_1015
  • ABP53490.1
 1144505 - 1145353 (+) 20S proteasome, A and B subunits
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  • Strop_1017
  • ABP53491.1
 1145798 - 1147576 (-) dihydroxyacid dehydratase
  • Precursor biosynthesis
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  • Strop_1018
  • ABP53492.1
 1147560 - 1148942 (-) crotonyl-CoA reductase
  • Precursor biosynthesis
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  • Strop_1019
  • ABP53493.1
 1148930 - 1149790 (-) alpha/beta hydrolase fold
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  • Strop_1020
  • ABP53494.1
 1149790 - 1150014 (-) MbtH domain protein
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  • Strop_1021
  • ABP53495.1
 1150011 - 1151288 (-) cytochrome P450
  • Tailoring (Unknown)
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  • Strop_1022
  • ABP53496.1
 1151285 - 1153078 (-) type II KS
  • Scaffold biosynthesis
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  • Strop_1023
  • ABP53497.1
 1153075 - 1154973 (-) NRPS (ACP-P)
  • Scaffold biosynthesis
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  • Strop_1024
  • ABP53498.1
 1154970 - 1161131 (-) PKS (ACP-AT-AT-KS-ACP-C)
  • Scaffold biosynthesis
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  • Strop_1025
  • ABP53499.1
 1161514 - 1162359 (+) hypothetical protein
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  • Strop_1026
  • ABP53500.1
 1162700 - 1163551 (-) 5'-CIDA synthase
  • Precursor biosynthesis
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  • Strop_1027
  • ABP53501.1
 1163691 - 1164458 (-) 5-CIR dehydrogenase
  • Precursor biosynthesis
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  • Strop_1028
  • ABP53502.1
 1164696 - 1165475 (+) 5-CIR phosphatase
  • Precursor biosynthesis
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  • Strop_1029
  • ABP53503.1
 1165480 - 1166313 (+) cyclase family protein
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  • Strop_1030
  • ABP53504.1
 1166345 - 1167022 (-) regulatory protein, LuxR
  • Regulation
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  • Strop_1031
  • ABP53505.1
 1167405 - 1170854 (+) alpha-keto decarboxylase
  • Precursor biosynthesis
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  • Strop_1032
  • ABP53506.1
 1171660 - 1172682 (-) regulatory protein, LysR
  • Regulation
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  • Strop_1033
  • ABP53507.1
 1173151 - 1173306 (+) hypothetical protein
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  • Strop_1034
  • ABP53508.1
 1173789 - 1174244 (-) acyl dehydratase
  • Precursor biosynthesis
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  • Strop_1035
  • ABP53509.1
 1174450 - 1175253 (-) 5'-CIDA phosphorylase
  • Precursor biosynthesis
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  • Strop_1036
  • ABP53510.1
 1175301 - 1176692 (-) DAHP synthase
  • Precursor biosynthesis
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  • Strop_1037
  • ABP53511.1
 1176969 - 1177268 (+) Stress responsive alpha-beta barrel domain protein
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  • Strop_1038
  • ABP53512.1
 1177316 - 1178731 (+) acyl-CoA ligase
  • Precursor biosynthesis
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  • Strop_1039
  • ABP53513.1
 1178731 - 1179693 (+) aminotransferase
  • Precursor biosynthesis
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  • Strop_1040
  • ABP53514.1
 1179690 - 1180343 (+) prephenate decarboxylase
  • Precursor biosynthesis
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  • Strop_1041
  • ABP53515.1
 1180357 - 1181346 (+) cyclodeaminase
  • Precursor biosynthesis
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  • Strop_1042
  • ABP53516.1
 1181393 - 1181686 (+) protein of unknown function DUF1330
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  • Strop_1043
  • ABP53517.1
 1181720 - 1182556 (+) epimerase
  • Precursor biosynthesis
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? yes
NRP-specific information
Subclass N/A
Cyclic? yes
NRP-synthases
Gene Modules
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: UJYWT4SZRXDY2IOPYAIF6MII, no GDPR consent given).
  • Hidden contributor (ID: NQ4XH53U6SBHJITINA72OVAX, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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