BGC0001052: tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9
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Location: 1 - 55,522 nt. (total: 55,522 nt).
This entry is originally from NCBI GenBank GU385216.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001052
Short description tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Ansamycin)
Loci NCBI GenBank: GU385216.1
Compounds
  • tirandamycin
Species Streptomyces sp. 307-9 [taxonomy]
References
Chemical products information
tirandamycin
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C22H27N1O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADC79635.1
 1 - 636 (-) TamM
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  • ADC79636.1
 770 - 2272 (+) TamL
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  • ADC79637.1
 2478 - 19964 (+) TamAI
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  • ADC79638.1
 20104 - 30201 (+) TamAII
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  • ADC79639.1
 30206 - 38611 (+) TamAIII
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  • ADC79640.1
 38608 - 39384 (+) TamB
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  • ADC79641.1
 39576 - 40406 (+) TamC
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  • ADC79642.1
 40523 - 43678 (+) TamD
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  • ADC79643.1
 43702 - 44532 (+) TamE
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  • ADC79644.1
 44529 - 46067 (+) TamF
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  • ADC79645.1
 46558 - 48651 (+) TamG
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  • ADC79646.1
 48917 - 51730 (+) TamH
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  • ADC79647.1
 51684 - 52925 (-) TamI
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  • ADC79648.1
 53232 - 54728 (-) TamJ
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  • ADC79649.1
 54890 - 55522 (+) TamK
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Polyketide-specific information
Subclass Ansamycin
Starter unit Malonyl-CoA
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
ADC79637.1
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ADC79638.1
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ADC79639.1 		Synthase subclass: Modular type I
Module 0
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: ADC79637.1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: ADC79637.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Inactive
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: ADC79637.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 3
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: ADC79637.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 4
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: ADC79638.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 5
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: ADC79638.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 6
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: ADC79639.1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 7
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: ADC79639.1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
ADC79642.1
Module 8
Specificity: glycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Linked new NPAtlas id for tirandamycin (npatlas:NPA017695)
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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