BGC0001056: zeamine biosynthetic gene cluster from Serratia plymuthica RVH1
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Location: 1 - 55,138 nt. (total: 55,138 nt).
This entry is originally from NCBI GenBank HE995400.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001056
Short description zeamine biosynthetic gene cluster from Serratia plymuthica RVH1
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: HE995400.1
Compounds
  • zeamine
  • zeamine I
  • zeamine II
  • prezeamine
  • prezeamine I
Species Serratia plymuthica RVH1 [taxonomy]
References
Chemical products information
zeamine
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C49H104N6O4
Chemical database entries
NPAtlas
zeamine I
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C47H100N6O3
zeamine II
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C40H87N5O1
prezeamine
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C71H133N15O13
prezeamine I
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C69H129N15O12
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCM44321.1
  • zmn1
 1 - 426 (+) hypothetical protein
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  • CCM44322.1
  • zmn2
 423 - 935 (+) hypothetical protein
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  • CCM44323.1
  • zmn3
 952 - 2325 (+) putative pyridoxal-dependent decarboxylase
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  • CCM44324.1
  • zmn4
 2373 - 3026 (+) hypothetical protein
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  • CCM44325.1
  • zmn5
 3096 - 3824 (-) Phosphopantetheinyl transferase
  • Unknown
Sequence-based prediction
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  • CCM44326.1
  • zmn6
 3895 - 4815 (-) putative HlyD family secretion protein
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  • CCM44327.1
  • zmn7
 4812 - 5531 (-) putative ABC transporter ATP-binding protein
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  • CCM44328.1
  • zmn8
 5540 - 6706 (-) putative ABC transporter membrane protein
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  • CCM44329.1
  • zmn9
 7316 - 8311 (+) hypothetical protein
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  • CCM44330.1
  • zmn10
 8448 - 15194 (+) Polyketide synthase
  • Scaffold biosynthesis
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  • CCM44331.1
  • zmn11
 15277 - 19527 (+) Mixed fatty acid synthase-polyketide synthase
  • Scaffold biosynthesis
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  • CCM44332.1
  • zmn12
 19524 - 22556 (+) PfaD family protein
  • Scaffold biosynthesis
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  • CCM44333.1
  • zmn13
 22553 - 23320 (+) 3-oxoacyl-ACP reductase
  • Scaffold biosynthesis
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  • CCM44334.1
  • zmn14
 23366 - 24598 (+) Thioester reductase
  • Scaffold biosynthesis
Activity assay
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  • CCM44335.1
  • zmn15
 24632 - 25411 (+) putative carbon-nitrogen hydrolase
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  • CCM44336.1
  • zmn16
 25460 - 37969 (+) Nonribosomal peptide synthetase
  • Scaffold biosynthesis
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  • CCM44337.1
  • zmn17
 37969 - 44511 (+) Nonribosomal peptide synthetase
  • Scaffold biosynthesis
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  • CCM44338.1
  • zmn18
 44508 - 49103 (+) Polyketide synthase
  • Scaffold biosynthesis
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  • CCM44339.1
  • zmn19
 49100 - 50419 (+) Condensation domain-containing protein
  • Scaffold biosynthesis
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  • CCM44340.1
  • zmn20
 50657 - 51601 (+) ABC transporter ATP-binding protein
  • Transport
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  • CCM44341.1
  • zmn21
 51594 - 52709 (+) ABC transporter permease
  • Transport
Sequence-based prediction
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  • CCM44342.1
  • zmn22
 52752 - 53789 (-) Acylpeptide hydrolase
  • Activation / processing
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  • CCM44343.1
  • zmn23
 54818 - 55138 (+) putative NifA subfamily transcriptional regulator
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Release type
  • Reductive release
Polyketide-synthases
Genes Properties Modules
zmn12
+
zmn11
+
zmn14
+
zmn18
+
zmn10
+
zmn13 		Synthase subclass: Modular type I/PUFA synthase or related
Module B6
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: zmn18
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
zmn16
Module B0
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Module B1
Specificity: histidine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Module B2
Specificity: asparagine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Module B3
Specificity: asparagine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
zmn17
Module B4
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Module B5
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: LBLIPTLAGFUPCXL63ODXWSCG, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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