BGC0001066: kendomycin biosynthetic gene cluster from Streptomyces violaceoruber
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Location: 1 - 66,606 nt. (total: 66,606 nt).
This entry is originally from NCBI GenBank AM992894.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001066
Short description kendomycin biosynthetic gene cluster from Streptomyces violaceoruber
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
AM992894.1
via Knock-out studies
Compounds
  • kendomycin
Species Streptomyces violaceoruber [taxonomy]
References
Chemical products information
kendomycin Evidence:
Copy SMILES
C29H42O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAQ52612.1
  • ken11
 177 - 617 (-) transcriptional regulator
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    • CAQ52613.1
    • ken10
    		 746 - 2377 (-) PQQ-dependent enzyme
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      • CAQ52614.1
      • ken9
      		 2374 - 3933 (-) methyl transferase
      • Precursor biosynthesis
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      • CAQ52615.1
      • ken7
      		 4327 - 5124 (-) enoyl-CoA hydratase
      • Precursor biosynthesis
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      • CAQ52616.1
      • ken6
      		 5121 - 6590 (-) benzaldehyde degydrogenase
      • Precursor biosynthesis
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      • CAQ52617.1
      • ken5
      		 6587 - 8278 (-) benzoyl formate decarboxylase
      • Precursor biosynthesis
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      • CAQ52618.1
      • ken4
      		 8275 - 9651 (-) dioxigenase
      • Precursor biosynthesis
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      • CAQ52619.1
      • ken3
      		 9713 - 10429 (-) enoyl-CoA hydratase/isomerase
      • Precursor biosynthesis
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      • CAQ52620.1
      • ken2
      		 10557 - 11657 (-) type III polyketide synthase
      • Precursor biosynthesis
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      • CAQ52621.1
      • ken1
      		 11711 - 12562 (-) type II thioesterase
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        • CAQ52622.1
        • ken12
        		 12831 - 24752 (+) type I polyketide synthase, modules 4-5
        • Scaffold biosynthesis
        • Knock-out
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        • CAQ52623.1
        • ken13
        		 24785 - 31303 (+) type I polyketide synthase, module 6
        • Scaffold biosynthesis
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        • CAQ52624.1
        • ken14
        		 31342 - 41685 (+) type I polyketide synthase, modules 7-8
        • Scaffold biosynthesis
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        • CAQ52625.1
        • ken15
        		 41682 - 42869 (+) FAD-dependent mono oxygenase
        • Tailoring
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        • CAQ52626.1
        • ken16
        		 42937 - 61329 (+) type I polyketide synthase, loading module and modules 1-3
        • Scaffold biosynthesis
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        • CAQ52627.1
        • ken17
        		 61490 - 62833 (+) putative lipase
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          • CAQ52628.1
          • ken18
          		 62863 - 63318 (+) hypothetical protein
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            • CAQ52629.1
            • ken19
            		 63315 - 64868 (+) FAD-dependent oxidoreductase
            • Tailoring
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            • CAQ52630.1
            • ken20
            		 64876 - 65466 (+) putative integral membrane protein
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              • CAQ52631.1
              • ken21
              		 65944 - 66387 (-) transcriptional regulator
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                Biosynthesis information

                Biosynthetic modules

                Name
                1
                Type
                pks-modular
                Genes
                ken12
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                Name
                2
                Type
                pks-modular
                Genes
                ken12
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                Name
                3
                Type
                pks-modular
                Genes
                ken12
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                Name
                4
                Type
                pks-modular
                Genes
                ken12
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                Name
                5
                Type
                pks-modular
                Genes
                ken12
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                Name
                6
                Type
                pks-modular
                Genes
                ken12
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                Name
                7
                Type
                pks-modular
                Genes
                ken12
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                Name
                8
                Type
                pks-modular
                Genes
                ken12
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Remove leading/trailing whitespace in gene identifiers
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Sorted modules by module number
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Updated bioactivity data
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2019-10-16
                Updated compound(s) information (NPAtlas curation)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: 7SR74ARK6JXRBGJRGO2LUHE7)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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