BGC0001074: cosmomycin D biosynthetic gene cluster from Streptomyces olindensis
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Location: 297,513 - 339,455 nt. (total: 41,943 nt).
This entry is originally from NCBI GenBank JJOH01000002.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001074
Short description cosmomycin D biosynthetic gene cluster from Streptomyces olindensis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Saccharide
  • Polyketide
Loci NCBI GenBank: JJOH01000002.1
Compounds
  • cosmomycin D
Species Streptomyces olindensis [taxonomy]
References
Chemical products information
cosmomycin D
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C60H88N2O22
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • DF19_23380
  • KDN80036.1
 297513 - 298367 (+) oxidoreductase
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  • DF19_23385
  • KDN80037.1
 298430 - 299305 (-) glucose-1-phosphate thymidylyltransferase
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  • DF19_23390
  • KDN80038.1
 299592 - 299846 (+) actinorhodin polyketide synthase acyl carrier protein
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  • DF19_23395
  • KDN80039.1
 300044 - 300886 (+) transcriptional regulator
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  • DF19_23400
  • KDN80040.1
 300973 - 301830 (-) methyltransferase
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  • DF19_23405
  • KDN80041.1
 302018 - 302455 (+) ester cyclase
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  • DF19_23410
  • KDN80042.1
 302497 - 303600 (+) methyltransferase
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  • DF19_23415
  • KDN80043.1
 303605 - 304501 (+) alpha/beta hydrolase
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  • DF19_23420
  • KDN80044.1
 304534 - 305247 (+) SAM-dependent methyltransferase
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  • DF19_23425
  • KDN80045.1
 305291 - 306886 (+) FAD-dependent oxidoreductase
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  • DF19_23430
  • KDN80046.1
 307143 - 308144 (-) oxidoreductase
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  • DF19_23435
  • KDN80047.1
 308340 - 309479 (+) hypothetical protein
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  • DF19_23440
  • KDN80048.1
 309476 - 310795 (+) glycosyl transferase
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  • DF19_23445
  • KDN80049.1
 310807 - 312108 (+) lipopolysaccharide biosynthesis protein RfbH
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  • DF19_23450
  • KDN80050.1
 312116 - 312901 (+) ketoacyl reductase
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  • DF19_23455
  • KDN80051.1
 312910 - 314268 (+) actinorhodin polyketide synthase
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  • DF19_23460
  • KDN80052.1
 314356 - 315087 (-) ketoreductase
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  • DF19_23465
  • KDN80053.1
 315112 - 315549 (-) hydroxylacyl-CoA dehydrogenase
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  • DF19_23470
  • KDN80054.1
 315698 - 316477 (+) cyclase
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  • DF19_23475
  • KDN80055.1
 316548 - 317276 (+) SAM-dependent methyltransferase
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  • DF19_23480
  • KDN80056.1
 317273 - 318382 (+) daunorubicin biosynthesis sensory transduction protein DnrJ
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  • DF19_23485
  • KDN80057.1
 318469 - 319914 (-) NDP-hexose 2,3-dehydratase
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  • DF19_23490
  • KDN80058.1
 319911 - 320915 (-) NAD-dependent epimerase
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  • DF19_23495
  • KDN80059.1
 320882 - 321508 (-) dTDP-4-dehydrorhamnose 3,5-epimerase
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  • DF19_23500
  • KDN80060.1
 321582 - 322874 (-) glycosyl transferase family 28
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  • DF19_23505
  • KDN80061.1
 323121 - 323684 (+) transcriptional regulator
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  • DF19_23510
  • KDN80062.1
 323792 - 324769 (+) hypothetical protein
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  • DF19_23520
  • KDN80063.1
 324886 - 325221 (+) antibiotic biosynthesis monooxygenase
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  • DF19_23525
  • KDN80064.1
 325218 - 326486 (+) beta-ACP synthase
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  • DF19_23530
  • KDN80065.1
 326483 - 327727 (+) beta-ketoacyl synthase
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  • DF19_23535
  • KDN80066.1
 327724 - 328758 (+) 3-oxoacyl-ACP synthase
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  • DF19_23540
  • KDN80067.1
 328755 - 329804 (+) polyketide synthase
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  • DF19_23545
  • KDN80068.1
 329948 - 331198 (+) cytochrome P450
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  • DF19_23550
  • KDN80069.1
 331233 - 332513 (+) glycosyl transferase family 28
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  • DF19_23555
  • KDN80070.1
 332536 - 333519 (+) dTDP-glucose 4,6-dehydratase
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  • DF19_23560
  • KDN80071.1
 333595 - 334584 (+) ABC transporter
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  • DF19_23565
  • KDN80072.1
 334581 - 335411 (+) multidrug ABC transporter permease
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  • DF19_23570
  • KDN80073.1
 335580 - 336062 (+) glutathione peroxidase
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  • DF19_23575
  • KDN80074.1
 336116 - 338401 (+) daunorubicin resistance protein DrrC
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  • DF19_23580
  • KDN80075.1
 338625 - 339455 (+) 3-ketoacyl-ACP reductase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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