BGC0001089: bacillaene biosynthetic gene cluster from Bacillus velezensis FZB42
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Location: 1 - 72,494 nt. (total: 72,494 nt).
This entry is originally from NCBI GenBank AJ634060.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001089
Short description bacillaene biosynthetic gene cluster from Bacillus velezensis FZB42
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
AJ634060.2
via Knock-out studies
Compounds
  • bacillaene
Species Bacillus velezensis FZB42 [taxonomy]
References
Chemical products information
bacillaene Evidence: NMR [1]
Copy SMILES
C34H50N2O6
Chemical database entries
PubCHEM
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAG23949.2
  • baeB
 1 - 693 (+) hydroxyacylglutathione hydrolase
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    • CAG23950.2
    • baeC
    		 996 - 1877 (+) malonyl-CoA-[acyl-carrier-protein] transacylase [AT]
    • Scaffold biosynthesis
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    • CAG23951.1
    • baeD
    		 1849 - 2988 (+) malonyl-CoA-[acyl-carrier-protein] transacylase [AT]
    • Scaffold biosynthesis
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    • CAG23952.1
    • baeE
    		 2990 - 5230 (+) malonyl-CoA-[acyl-carrier protein] transacylase [AT]/oxidoreductase [OR]
    • Scaffold biosynthesis
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    • CAG23953.1
    • acpK
    		 5296 - 5544 (+) acyl carrier protein
    • Scaffold biosynthesis
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    • CAG23954.2
    • baeG
    		 5581 - 6858 (+) 3-hydroxy-3-methylglutaryl CoA synthase
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      • CAG23955.1
      • baeH
      		 6846 - 7628 (+) polyketide biosynthesis enoyl-CoA hydratase
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        • CAG23956.1
        • baeI
        		 7638 - 8387 (+) polyketide biosynthesis enoyl-CoA hydratase
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          • CAG23957.2
          • baeJ
          		 8427 - 23375 (+) hybrid NRPS/PKS protein
          • Scaffold biosynthesis
          • Knock-out
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          • CAG23958.2
          • baeL
          		 23377 - 36804 (+) polyketide synthase of type I
          • Scaffold biosynthesis
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          • CAG23959.2
          • baeM
          		 36822 - 47357 (+) polyketide synthase of type I
          • Scaffold biosynthesis
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          • CAG23960.2
          • baeN
          		 47347 - 63648 (+) hybrid NRPS/PKS protein
          • Scaffold biosynthesis
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          • CAG23961.2
          • baeR
          		 63662 - 71110 (+) polyketide synthase of type I
          • Scaffold biosynthesis
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          • CAG23962.1
          • baeS
          		 71247 - 72494 (-) cytochrome P450 'oxidase'
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            Biosynthesis information
            Annotation changelog

            Entry version: next

            Date
            Changes
            Submitters
            Reviewers
            2024-05-20
            MIBiG v4 annotathon
            • (ID: IRCE2EOKBOKIESIQAHCXHTJV)
            • (ID: FICEQDRJCNKWHHGNCRVDDP5D)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 4

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-09-15
            Linked new PubChem id for bacillaene (pubchem:25144999)
            • (ID: 5UL74VURKJ25VSPPPO3H2NYB)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Corrected NRP module activity
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Changed annotations to use correct gene idenitifers
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Removed ketoreductase stereochemistry annotation from modules without ketoreductases
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Merged cross-CDS PKS modules and corrected others
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Changed amino acid substrates to lower case
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2015-06-12
            Submitted
            • (ID: FICEQDRJCNKWHHGNCRVDDP5D)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            Detailed domain annotation
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