BGC0001089: bacillaene biosynthetic gene cluster from Bacillus velezensis FZB42
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Location: 1 - 72,494 nt. (total: 72,494 nt).
This entry is originally from NCBI GenBank AJ634060.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001089
Short description bacillaene biosynthetic gene cluster from Bacillus velezensis FZB42
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
  • NRP
Loci NCBI GenBank: AJ634060.2
Compounds
  • bacillaene
Species Bacillus velezensis FZB42 [taxonomy]
References
Chemical products information
bacillaene
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C34H50N2O6
Chemical database entries
PubCHEM
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAG23949.2
  • baeB
 1 - 693 (+) hydroxyacylglutathione hydrolase
  • Other enzymatic
Sequence-based prediction
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  • CAG23950.2
  • baeC
 996 - 1877 (+) malonyl-CoA-[acyl-carrier-protein] transacylase [AT]
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAG23951.1
  • baeD
 1849 - 2988 (+) malonyl-CoA-[acyl-carrier-protein] transacylase [AT]
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAG23952.1
  • baeE
 2990 - 5230 (+) malonyl-CoA-[acyl-carrier protein] transacylase [AT]/oxidoreductase [OR]
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAG23953.1
  • acpK
 5296 - 5544 (+) acyl carrier protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAG23954.2
  • baeG
 5581 - 6858 (+) 3-hydroxy-3-methylglutaryl CoA synthase
  • Other enzymatic
Sequence-based prediction
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  • CAG23955.1
  • baeH
 6846 - 7628 (+) polyketide biosynthesis enoyl-CoA hydratase
  • Other enzymatic
Sequence-based prediction
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  • CAG23956.1
  • baeI
 7638 - 8387 (+) polyketide biosynthesis enoyl-CoA hydratase
  • Other enzymatic
Sequence-based prediction
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  • CAG23957.2
  • baeJ
 8427 - 23375 (+) hybrid NRPS/PKS protein
  • Scaffold biosynthesis
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  • CAG23958.2
  • baeL
 23377 - 36804 (+) polyketide synthase of type I
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAG23959.2
  • baeM
 36822 - 47357 (+) polyketide synthase of type I
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAG23960.2
  • baeN
 47347 - 63648 (+) hybrid NRPS/PKS protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAG23961.2
  • baeR
 63662 - 71110 (+) polyketide synthase of type I
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAG23962.1
  • baeS
 71247 - 72494 (-) cytochrome P450 'oxidase'
  • Other enzymatic
Sequence-based prediction
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Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
baeJ
+
baeL
+
baeM
+
baeN
+
baeR 		Synthase subclass:
Module 2
Genes: baeJ
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Genes: baeJ
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Genes: baeJ, baeL
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Non-canonical activity:
  • Non-elongating
Evidence for non-canonical activity:
  • Sequence-based prediction
Module 5
Genes: baeL
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Genes: baeL
Core domains: Ketosynthase, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
Module 7
Genes: baeL
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 8
Genes: baeL
Core domains: Ketosynthase
Non-canonical activity:
  • Non-elongating
Evidence for non-canonical activity:
  • Structure-based inference
Module 9
Genes: baeM
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 10
Genes: baeM
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 12
Genes: baeN
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 13
Genes: baeN
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 14
Genes: baeN, baeR
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 15
Genes: baeR
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Non-canonical activity:
  • Skipped
Evidence for non-canonical activity:
  • Structure-based inference
Module 16
Genes: baeR
Core domains: Ketosynthase, Thiolation (ACP/PCP), Thioesterase
Non-canonical activity:
  • Skipped
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
baeJ
Module 0
Condensation domain type: LCL
Module 1
Specificity: glycine
Evidence for specificity:
Condensation domain type: LCL
baeN
Module 11
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: FICEQDRJCNKWHHGNCRVDDP5D, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Linked new PubChem id for bacillaene (pubchem:25144999)
  • Corrected NRP module activity
  • Changed annotations to use correct gene idenitifers
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Merged cross-CDS PKS modules and corrected others
  • Changed amino acid substrates to lower case
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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