BGC0001090: bacillomycin D biosynthetic gene cluster from Bacillus velezensis FZB42
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Location: 1,867,976 - 1,912,622 nt. (total: 44,647 nt).
This entry is originally from NCBI GenBank CP000560.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001090
Short description bacillomycin D biosynthetic gene cluster from Bacillus velezensis FZB42
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Other lipopeptide)
  • Polyketide
Loci NCBI GenBank: CP000560.1
Compounds
  • bacillomycin D
Species Bacillus velezensis FZB42 [taxonomy]
References
Chemical products information
bacillomycin D
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C49H76N10O15
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RBAM_018140
  • ABS74177.1
  • ynfF
 1867976 - 1869247 (-) YnfF
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  • RBAM_018150
  • ABS74178.1
  • xynD
 1869309 - 1870847 (-) XynD
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  • RBAM_018160
  • ABS74179.1
  • bmyC
 1871172 - 1879031 (-) bacillomycin D synthetase C
  • Scaffold biosynthesis
Sequence-based prediction
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  • RBAM_018170
  • ABS74180.1
  • bmyB
 1879116 - 1895207 (-) bacillomycin D synthetase B
  • Scaffold biosynthesis
Sequence-based prediction
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  • RBAM_018180
  • ABS74181.1
  • bmyA
 1895252 - 1907200 (-) bacillomycin D synthetase A
  • Scaffold biosynthesis
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  • RBAM_018190
  • ABS74182.1
  • bmyD
 1907220 - 1908422 (-) malonyl-CoA transacylase
  • Scaffold biosynthesis
Sequence-based prediction
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  • RBAM_018200
  • ABS74183.1
  • yxjF
 1908982 - 1909767 (-) YxjF
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  • RBAM_018210
  • ABS74184.1
  • scoB
 1909780 - 1910442 (-) ScoB
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  • RBAM_018220
  • ABS74185.1
  • scoA
 1910460 - 1911161 (-) ScoA
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  • RBAM_018230
  • ABS74186.1
  • yxjC
 1911186 - 1912622 (-) YxjC
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Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
bmyD
+
bmyA 		Synthase subclass:
Module ?
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: bmyD
Core domains: Acyltransferase
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Sequence-based prediction
Module 2
Genes: bmyA
Core domains: Ketosynthase, Thiolation (ACP/PCP)
NRP-specific information
Subclass Other lipopeptide
Cyclic? yes
NRP-synthases
Gene Modules
bmyA
Module 1
Condensation domain type: Unknown
Module 3
Condensation domain type: Unknown
Modification domains: Amination
Module 4
Specificity: asparagine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: LCL
Module 5
Condensation domain type: DCL
bmyB
Module 5
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module 6
Specificity: asparagine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: DCL
Module 7
Specificity: proline
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: LCL
Module 8
Specificity: glutamic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: LCL
Module 9
Condensation domain type: DCL
bmyC
Module 10
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Condensation domain type: LCL
Module 9
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: FICEQDRJCNKWHHGNCRVDDP5D, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Corrected gene identifiers
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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