BGC0001110: psymberin biosynthetic gene cluster from uncultured bacterium psy1
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Location: 1 - 72,054 nt. (total: 72,054 nt).
This entry is originally from NCBI GenBank FJ823461.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001110
Short description psymberin biosynthetic gene cluster from uncultured bacterium psy1
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Psymberin harbors an isocoumarin group, hence it is cyclized and contains a lactone. However, it is not a macrolactone."
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: FJ823461.1
Compounds
  • psymberin
  • irciniastatin B
Species uncultured bacterium psy1 [taxonomy]
References
Chemical products information
psymberin [synonyms: irciniastatin a]
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C31H47N1O11
Chemical database entries
PubCHEM
PubCHEM
irciniastatin B
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C31H45N1O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADA82578.1
 551 - 1459 (+) zinc-dependent hydrolase
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  • ADA82579.1
 1641 - 2921 (+) adenylosuccinate synthetase
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  • ADA82580.1
 3136 - 4239 (+) transposase
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  • ADA82581.1
 4482 - 14375 (+) trans-AT polyketide synthase
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  • ADA82582.1
 14379 - 15374 (-) methyltransferase
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  • ADA82583.1
 15375 - 16406 (-) PedK-like protein
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  • ADA82594.1
 17039 - 18142 (+) transposase
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  • ADA82584.1
 18708 - 20183 (+) transposase
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  • ADA82585.1
 20598 - 58535 (+) hybrid trans-AT polyketide synthase - nonribosomal peptide synthetase
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  • ADA82586.1
 58605 - 60320 (+) phosphoenolpyruvate synthase, beta and gamma subunit
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  • ADA82587.1
 60325 - 61818 (+) phosphoesterase
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  • ADA82588.1
 61830 - 62759 (+) phosphoenolpyruvate synthase alpha subunit
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  • ADA82589.1
 62803 - 63912 (+) acyltransferase
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  • ADA82596.1
 64017 - 65279 (+) 3-hydroxy-3-methylglutaryl-CoA synthase family
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  • ADA82590.1
 65279 - 66043 (+) crotonase superfamily
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  • ADA82591.1
 66047 - 67150 (+) flavin-dependent oxidoreductase
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  • ADA82592.1
 67179 - 67424 (+) acylcarrierprotein
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  • ADA82593.1
 67411 - 68700 (+) 3-oxoacyl ACP synthase
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  • ADA82595.1
 68781 - 70910 (-) transport ATPase
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
ADA82581.1
+
ADA82589.1
+
ADA82585.1 		Synthase subclass: Trans-AT type I
Trans-acyltansferases: ADA82589.1
Module 0
Specificity: Acetyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: ADA82581.1
Core domains: Acyltransferase, Thiolation (ACP/PCP)
Module 1
Genes: ADA82581.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 2
Genes: ADA82581.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Genes: ADA82585.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 5
Genes: ADA82585.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Genes: ADA82585.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 7
Genes: ADA82585.1
Core domains: Ketosynthase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Pyran synthase
KR-domain stereochemistry: Unknown
Module 8
Genes: ADA82585.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 9
Genes: ADA82585.1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 10
Genes: ADA82585.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 11
Genes: ADA82585.1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 12
Genes: ADA82585.1
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
ADA82585.1
Module 4
Specificity: glycine
Evidence for specificity:
  • Sequence-based prediction
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: HQRJ2JJOIHRZHPXZ4JGWECPL, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: 5UL74VURKJ25VSPPPO3H2NYB, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update compound structure (SMILES) for psymberin
  • Linked new PubChem id for psymberin (pubchem:11692946)
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Sorted modules by module number
  • Removed invalid subcluster annotation
  • Updated bioactivity data
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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