BGC0001117: himastatin biosynthetic gene cluster from Streptomyces himastatinicus ATCC 53653
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Location: 1 - 51,421 nt. (total: 51,421 nt).
This entry is originally from NCBI GenBank FR823394.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001117
Short description himastatin biosynthetic gene cluster from Streptomyces himastatinicus ATCC 53653
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: FR823394.1
Compounds
  • himastatin
Species Streptomyces himastatinicus ATCC 53653 [taxonomy]
References
Chemical products information
himastatin
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C72H104N14O20
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CBZ42132.1
 1 - 807 (+) hypothetical protein
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  • CBZ42133.1
 821 - 1417 (-)
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  • CBZ42134.1
 1473 - 2300 (+)
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  • CBZ42135.1
  • hmtA
 2356 - 3099 (+) putative MerR family transcriptional regulator
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  • CBZ42136.1
  • hmtB
 3468 - 4451 (-) acetylglutamate kinase
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  • CBZ42137.1
  • hmtC
 4675 - 5319 (+) putative negative regulator
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  • CBZ42138.1
  • hmtD
 5391 - 6074 (-) regulator
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  • CBZ42139.1
  • hmtE
 6632 - 7189 (-) hypothetical protein
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  • CBZ42140.1
  • hmtF
 7255 - 10242 (-) non-ribosomal peptide synthetase
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  • CBZ42141.1
  • hmtG
 10325 - 11155 (-) Acyl-Co Adehydrogenase
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  • CBZ42142.1
  • hmtH
 11170 - 11868 (-) putative thioesterase
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  • CBZ42143.1
  • hmtI
 12303 - 18479 (+) putative non-ribosomal peptide synthetase
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  • CBZ42144.1
  • hmtJ
 18495 - 19274 (+) putative thioesterase
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  • CBZ42145.1
  • hmtK
 19271 - 23056 (+) non-ribosomal peptide synthetase
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  • CBZ42146.1
  • hmtL
 23076 - 38321 (+) putative non-ribosomal peptide synthetase
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  • CBZ42147.1
  • hmtM
 38387 - 39685 (+) peptide monooxygenase
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  • CBZ42148.1
  • hmtN
 39920 - 41119 (+) P450-like enzyme
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  • CBZ42149.1
  • hmtO
 41281 - 41802 (+) hypothetical protein
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  • CBZ42150.1
  • hmtP
 41843 - 42694 (+) hypothetical protein
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  • CBZ42151.1
  • hmtQ
 42754 - 43707 (+) putative ABC-2 transporter
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  • CBZ42152.1
  • hmtR
 43704 - 44546 (+) putative ABC-2 type transporter
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  • CBZ42153.1
  • hmtS
 44738 - 45931 (+) putative P450-like enzyme
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  • CBZ42154.1
  • hmtT
 45979 - 47172 (+) putative P450-like enzyme
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  • CBZ42155.1
 47249 - 48259 (+)
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  • CBZ42156.1
 48275 - 51421 (-)
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
hmtF
Module ?
Specificity: piperazic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
hmtI
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
hmtK
Module ?
Specificity: 2-ketoisovaleric acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
hmtL
Module ?
Specificity: leucine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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