BGC0001119: divergolide A biosynthetic gene cluster from Streptomyces sp. HKI0576
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Location: 1 - 72,571 nt. (total: 72,571 nt).
This entry is originally from NCBI GenBank HF563079.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001119
Short description divergolide A biosynthetic gene cluster from Streptomyces sp. HKI0576
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
HF563079.1
via
Compounds
  • divergolide A
  • divergolide B
  • divergolide C
  • divergolide D
Species Streptomyces sp. HKI0576 [taxonomy]
References
Chemical products information
divergolide A Evidence:
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C31H39N1O8
Chemical database entries
PubCHEM
ChemSpider
divergolide B Evidence:
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C31H37N1O7
Chemical database entries
PubCHEM
ChemSpider
divergolide C Evidence:
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C31H35N1O8
Chemical database entries
PubCHEM
ChemSpider
divergolide D Evidence:
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C31H35N1O8
Chemical database entries
PubCHEM
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCP20037.1
  • divA
 138 - 1454 (+) divA protein
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    • CCP20038.1
    • divB
    		 1491 - 2507 (-) divB protein
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      • CCP20039.1
      • divC
      		 2758 - 3720 (-) divC protein
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        • CCP20040.1
        • divD
        		 3729 - 5108 (-) divD protein
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          • CCP20041.1
          • divE
          		 5221 - 6759 (-) divE protein
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            • CCP20042.1
            • divF
            		 6780 - 7214 (-) divF protein
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              • CCP20043.1
              • divG
              		 7362 - 8525 (+) divG protein
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                • CCP20044.1
                • divH
                		 8522 - 9586 (+) divH protein
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                  • CCP20045.1
                  • divI
                  		 9610 - 10236 (+) divI protein
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                    • CCP20046.1
                    • divJ
                    		 10220 - 11278 (+) divJ protein
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                      • CCP20047.1
                      • divK
                      		 11548 - 27195 (+) divK protein
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                        • CCP20048.1
                        • divL1
                        		 27192 - 33833 (+) divL1 protein
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                          • CCP20049.1
                          • divL2
                          		 33830 - 39217 (+) divL2 protein
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                            • CCP20050.1
                            • divL3
                            		 39214 - 45816 (+) divL3 protein
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                              • CCP20051.1
                              • divM
                              		 45813 - 54056 (+) divM protein
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                                • CCP20052.1
                                • divN
                                		 54094 - 54849 (+) divN protein
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                                  • CCP20053.1
                                  • divO
                                  		 54849 - 56075 (+) divO protein
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                                    • CCP20054.1
                                    • divP
                                    		 56203 - 56967 (+) divP protein
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                                      • CCP20055.1
                                      • divQ
                                      		 57034 - 58221 (-) divQ protein
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                                        • CCP20056.1
                                        • divR
                                        		 58361 - 59722 (+) divR protein
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                                          • CCP20057.1
                                          • divS
                                          		 59729 - 60730 (+) divS protein
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                                            • CCP20058.1
                                            • divT
                                            		 60727 - 61587 (+) divT protein
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                                              • CCP20059.1
                                              • divU
                                              		 61988 - 64771 (+) divU protein
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                                                • CCP20060.1
                                                • divV
                                                		 64820 - 65449 (+) divV protein
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                                                  • CCP20061.1
                                                  • divW
                                                  		 66216 - 66890 (+) divW protein
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                                                    • CCP20062.1
                                                    • divGNAT
                                                    		 67568 - 68314 (+) divGNAT protein
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                                                      • CCP20063.1
                                                      • divX
                                                      		 68640 - 69839 (+) divX protein
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                                                        • CCP20064.1
                                                        • divY
                                                        		 69859 - 71235 (+) divY protein
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                                                          • CCP20065.1
                                                          • divZ
                                                          		 71232 - 72503 (+) divZ protein
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                                                            Biosynthesis information

                                                            Biosynthetic modules

                                                            Name
                                                            0
                                                            Type
                                                            pks-trans-at-starter
                                                            Genes
                                                            divK
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            ketoreductase, ligase, carrier (ACP)
                                                            Name
                                                            1
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            divK
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                            Name
                                                            2
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            divK
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                            Name
                                                            3
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            divK
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                            Name
                                                            4
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            divL1
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                                                            Name
                                                            5
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            divL2
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                            Name
                                                            6
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            divL3
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                                                            Name
                                                            7
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            divM
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                            Name
                                                            8
                                                            Type
                                                            pks-modular
                                                            Genes
                                                            divM
                                                            Substrates
                                                            Integrated Monomers
                                                            Domains
                                                            acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                            Annotation changelog

                                                            Entry version: 4

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-10-07
                                                            Update chemical activity to schema version 2.11
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 3

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-09-15
                                                            Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2022-09-15
                                                            Updated bioactivity data
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 2

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2019-10-16
                                                            Migrated from v1.4
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2019-10-16
                                                            Updated compound(s) information (NPAtlas curation)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 1

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2015-06-12
                                                            Submitted
                                                            • (ID: F65XGYSSLMUEJC2Q4T3BLCPS)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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