BGC0001126: 12-epi-hapalindole J isonitrile biosynthetic gene cluster from Fischerella ambigua UTEX 1903
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 41,745 nt. (total: 41,745 nt).
This entry is originally from NCBI GenBank KF664586.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
Tailoring
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001126
Short description 12-epi-hapalindole J isonitrile biosynthetic gene cluster from Fischerella ambigua UTEX 1903
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Monoterpene)
  • other (other)
Loci
KF664586.1
via Enzymatic assays
Compounds
  • 12-epi-hapalindole J isonitrile
  • ambiguine A isonitrile
  • ambiguine B isonitrile
  • ambiguine C isonitrile
  • ambiguine D isonitrile
  • ambiguine E isonitrile
  • ambiguine K isonitrile
  • ambiguine L isonitrile
  • ambiguine I isonitrile
  • ambiguine J isonitrile
Species Fischerella ambigua UTEX 1903 [taxonomy]
References
Chemical products information
12-epi-hapalindole J isonitrile Evidence:
Copy SMILES
C21H24N2
Chemical database entries
NPAtlas
ambiguine A isonitrile Evidence:
Copy SMILES
C26H31Cl1N2
Chemical database entries
PubCHEM
ChemSpider
ambiguine B isonitrile Evidence:
Copy SMILES
C26H31Cl1N2O1
Chemical database entries
PubCHEM
ambiguine C isonitrile Evidence:
Copy SMILES
C26H32N2O1
Chemical database entries
PubCHEM
ambiguine D isonitrile Evidence:
Copy SMILES
C26H29Cl1N2O3
Chemical database entries
PubCHEM
ambiguine E isonitrile Evidence:
Copy SMILES
C26H29Cl1N2O2
Chemical database entries
PubCHEM
ambiguine K isonitrile Evidence:
Copy SMILES
C26H29Cl1N2O1
Chemical database entries
NPAtlas
PubCHEM
ambiguine L isonitrile Evidence:
Copy SMILES
C26H30N2O1
Chemical database entries
NPAtlas
PubCHEM
ambiguine I isonitrile Evidence:
Copy SMILES
C26H30N2O2
Chemical database entries
NPAtlas
ChEBI
ambiguine J isonitrile Evidence:
Copy SMILES
C26H30N2O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHB62752.1
 257 - 712 (+) conserved membrane hypothetical protein (possible transporter)
  • Transport
copy AA seq
copy Nt seq
  • AHB62753.1
 720 - 1913 (+) ABC exporter membrane fusion protein, DevB family
  • Transport
copy AA seq
copy Nt seq
  • AHB62754.1
 1937 - 3103 (+) DevC protein
  • Transport
copy AA seq
copy Nt seq
  • AHB62755.1
 3510 - 4460 (-) halogenase, 2OG-Fe(II) oxygenase family
  • Tailoring
  • Activity assay
copy AA seq
copy Nt seq
  • AHB62756.1
 4585 - 5442 (-) rieske oxygenase
  • Tailoring
copy AA seq
copy Nt seq
  • AHB62757.1
 5880 - 6587 (-) unknown function
    copy AA seq
    copy Nt seq
    • AHB62758.1
    		 6960 - 7652 (-) AmbU3
      copy AA seq
      copy Nt seq
      • AHB62759.1
      		 7982 - 8698 (-) AmbU2
        copy AA seq
        copy Nt seq
        • AHB62760.1
        		 8992 - 9711 (-) AmbU1
          copy AA seq
          copy Nt seq
          • AHB62761.1
          		 9766 - 10857 (-) rieske oxygenase
          • Tailoring
          copy AA seq
          copy Nt seq
          • AHB62762.1
          		 11166 - 12248 (-) rieske oxygenase
          • Tailoring
          copy AA seq
          copy Nt seq
          • AHB62763.1
          		 12336 - 13415 (-) rieske oxygenase
          • Tailoring
          copy AA seq
          copy Nt seq
          • AHB62764.1
          		 13715 - 14683 (-) aromatic prenyl transferase
          • Scaffold biosynthesis
          • Activity assay
          copy AA seq
          copy Nt seq
          • AHB62765.1
          		 14911 - 16113 (-) 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (IspH)
          • Precursor biosynthesis
          copy AA seq
          copy Nt seq
          • AHB62766.1
          		 16186 - 17226 (-) geranyl diphosphate synthase
          • Precursor biosynthesis
          • Activity assay
          copy AA seq
          copy Nt seq
          • AHB62767.1
          		 19791 - 20489 (+) LuxR family transcriptional regulator
          • Regulation
          copy AA seq
          copy Nt seq
          • AHB62768.1
          		 20721 - 21455 (-) LuxR family transcriptional regulator
          • Regulation
          copy AA seq
          copy Nt seq
          • AHB62769.1
          		 22948 - 23526 (+) dephospho-CoA kinase-like protein
          • Precursor biosynthesis
          copy AA seq
          copy Nt seq
          • AHB62770.1
          		 23591 - 24811 (+) 1-deoxy-D-xylulose 5-phosphate reductoisomerase (IspC, Dxr)
          • Precursor biosynthesis
          copy AA seq
          copy Nt seq
          • AHB62771.1
          		 25117 - 26076 (+) isonitrile indole synthase A (IsnA)
          • Scaffold biosynthesis
          • Activity assay
          copy AA seq
          copy Nt seq
          • AHB62772.1
          		 26268 - 27260 (+) isonitrile indole synthase A (IsnA)
          • Scaffold biosynthesis
          • Activity assay
          copy AA seq
          copy Nt seq
          • AHB62773.1
          		 27260 - 28081 (+) isonitrile indole synthase B (IsnB)
          • Scaffold biosynthesis
          • Activity assay
          copy AA seq
          copy Nt seq
          • AHB62774.1
          		 28558 - 29487 (+) aromatic prenyl transferase
          • Scaffold biosynthesis
          • Activity assay
          copy AA seq
          copy Nt seq
          • AHB62775.1
          		 29744 - 31687 (+) 1-deoxy-D-xylulose-5-phosphate synthase (DXS)
          • Precursor biosynthesis
          copy AA seq
          copy Nt seq
          • AHB62776.1
          		 31760 - 32986 (+) 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (IspG)
          • Precursor biosynthesis
          copy AA seq
          copy Nt seq
          • AHB62777.1
          		 33201 - 34106 (+) 3-deoxy-D-arabinoheptulosonate 7-phosphate (DAHP) synthase
          • Scaffold biosynthesis
          copy AA seq
          copy Nt seq
          • AHB62778.1
          		 34160 - 36364 (+) anthranilate synthase (TrpE)
          • Precursor biosynthesis
          copy AA seq
          copy Nt seq
          • AHB62779.1
          		 36609 - 37460 (+) indole-3-glycerol phosphate synthase (TrpC)
          • Precursor biosynthesis
          copy AA seq
          copy Nt seq
          • AHB62780.1
          		 37512 - 38324 (+) tryptophan synthase subunit alpha (TrpA)
          • Precursor biosynthesis
          copy AA seq
          copy Nt seq
          • AHB62781.1
          		 38486 - 39736 (+) tryptophan synthase subunit beta (TrpB)
          • Precursor biosynthesis
          copy AA seq
          copy Nt seq
          • AHB62782.1
          		 39772 - 40869 (+) anthranilate phosphoribosyltransferase (TrpD)
          • Precursor biosynthesis
          copy AA seq
          copy Nt seq
          • AHB62783.1
          		 40894 - 41538 (+) phosphoglycerate mutase family protein
          • Precursor biosynthesis
          copy AA seq
          copy Nt seq
          Biosynthesis information

          No biosynthesis information available for this record.

          Annotation changelog

          Entry version: 3

          Date
          Changes
          Submitters
          Reviewers
          2022-10-07
          Update chemical activity to schema version 2.11
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 2

          Date
          Changes
          Submitters
          Reviewers
          2019-10-16
          Migrated from v1.4
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2019-10-16
          Updated compound(s) information (NPAtlas curation)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 1

          Date
          Changes
          Submitters
          Reviewers
          2015-06-12
          Submitted
          • (ID: XU7PTWDFW5UJ7GLIWVSFLQRF)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          Tailoring functions
          Tailoring enzymes detected in this region
          Oxidoreductases: oxygenase
          AHB62773.1: dioxygenase, TauD/TfdA
          smcogs
          SMCOG1121: dioxygenase, TauD/TfdA
          Isomerases: isomerase mutase
          AHB62778.1: isochorismate synthase
          smcogs
          SMCOG1018: isochorismate synthase
          AHB62783.1: phosphoglycerate mutase
          smcogs
          SMCOG1101: phosphoglycerate mutase
          Ligases: synthase synthetase
          AHB62766.1: Polyprenyl synthetase
          smcogs
          SMCOG1182: Polyprenyl synthetase
          AHB62775.1: 1-deoxy-D-xylulose-5-phosphate synthase
          smcogs
          SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase
          AHB62781.1: cysteine synthase
          smcogs
          SMCOG1081: cysteine synthase
          Similar known clusters from MIBiG 4.0
          Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
          Detailed help and explanations are available here.

          Click on reference genes to show details of similarities to genes within the current region.
          Double click on a reference drawing to reverse the display of the genes.

          Click on an accession to open that entry in the MIBiG database.


          Location:

          Identifier
          Identity
          Coverage