BGC0001150: pamamycin-607 biosynthetic gene cluster from Streptomyces alboniger
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Location: 1 - 23,437 nt. (total: 23,437 nt).
This entry is originally from NCBI GenBank KM923741.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001150
Short description pamamycin-607 biosynthetic gene cluster from Streptomyces alboniger
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: KM923741.1
Compounds
  • pamamycin-607
Species Streptomyces alboniger [taxonomy]
References
Chemical products information
pamamycin-607
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C35H61N1O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SALB_00464
  • AJS09379.1
  • pamR2
 13 - 750 (-) TetR family transcription regulator
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  • SALB_00465
  • AJS09380.1
  • pamW
 838 - 2514 (+) drug resistance transporter, EmrB/QacA family
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  • SALB_00466
  • AJS09381.1
  • pamC
 2611 - 2841 (-) acyl-carrier protein
  • Precursor biosynthesis
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  • SALB_00467
  • AJS09382.1
  • pamG
 2895 - 3929 (-) Ketoacyl-acyl carrier protein synthase III
  • Scaffold biosynthesis
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  • SALB_00468
  • AJS09383.1
  • pamF
 3941 - 5260 (-) Ketoacyl-acyl carrier protein synthase II
  • Scaffold biosynthesis
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  • SALB_00469
  • AJS09384.1
  • pamA
 5472 - 6809 (+) Ketoacyl-acyl carrier protein synthase II
  • Scaffold biosynthesis
Activity assay
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  • SALB_00470
  • AJS09385.1
  • pamB
 6806 - 8668 (+) 3-ketoacid (adipate/glutaconate) CoA transferase
  • Scaffold biosynthesis
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  • SALB_00471
  • AJS09386.1
  • pamD
 8706 - 9665 (+) Ketoacyl-acyl carrier protein synthase III
  • Scaffold biosynthesis
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  • SALB_00472
  • AJS09387.1
  • pamE
 9718 - 10752 (+) Ketoacyl-acyl carrier protein synthase III
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  • SALB_00473
  • AJS09388.1
  • pamO
 10806 - 11600 (+) Ketoacyl-(acyl-carrier-protein) reductase
  • Tailoring (Reduction)
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  • SALB_00474
  • AJS09389.1
  • pamK
 11685 - 12695 (+) Ketoacyl-acyl carrier protein synthase III
  • Scaffold biosynthesis
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  • SALB_00475
  • AJS09390.1
  • pamJ
 12712 - 14007 (+) Ketoacyl-acyl carrier protein synthase II
  • Scaffold biosynthesis
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  • SALB_00476
  • AJS09391.1
  • pamM
 14000 - 15577 (+) Ketoacyl-(acyl-carrier-protein) reductase
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  • SALB_00477
  • AJS09392.1
  • pamN
 15574 - 16401 (+) Ketoacyl-(acyl-carrier-protein) reductase
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  • SALB_00478
  • AJS09393.1
  • pamL
 16398 - 18101 (+) Hydroxyl acids CoA ligase
  • Activation / processing
Other in vivo study
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  • SALB_00479
  • AJS09394.1
  • pamH
 18085 - 19068 (+) Metal-dependent hydrolase (resistance)
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  • SALB_00480
  • AJS09395.1
  • pamX
 19165 - 20511 (+) Aminotransferase
  • Tailoring (Amination)
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  • SALB_00481
  • AJS09396.1
  • pamY
 20560 - 21381 (+) Methyltransferase
  • Tailoring (Methylation)
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  • SALB_00482
  • AJS09397.1
  • pamS
 21599 - 22405 (+) Enoyl-CoA hydratase
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  • SALB_00483
  • AJS09398.1
  • pamR1
 22430 - 23077 (-) Response regulator LuxR family
  • Regulation
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Polyketide-specific information
Subclass Unknown
Ketide length 26
Cyclic? no
Polyketide-synthases
Genes Properties Modules
pamA
+
pamK
+
pamE
+
pamD
+
pamJ
+
pamG
+
pamF 		Synthase subclass: Type II/Type III
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: YECXNWBIVB4ZABFMZK4W53HU, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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