BGC0001155: GE2270 biosynthetic gene cluster from Planobispora rosea
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Location: 4,201 - 25,722 nt. (total: 21,522 nt).
This entry is originally from NCBI GenBank KF366381.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001155
Short description GE2270 biosynthetic gene cluster from Planobispora rosea
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • ribosomal (RiPP)
Loci
KF366381.2
4201 - 25722
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • GE2270
Species Planobispora rosea [taxonomy]
References
Chemical products information
GE2270 Evidence:
Copy SMILES
C56H55N15O10S6
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGY49580.1
  • pbtR
 4301 - 5014 (+) TetR transcriptional regulator
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    • AGY49581.1
    • pbtG1
    		 5068 - 6891 (+) cyclodehydratase (oxazoline formation)
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      • AGY49582.1
      • pbtB1
      		 6888 - 9266 (+) dehydratase
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        • AGY49583.1
        • pbtO
        		 9263 - 10297 (+) P450 monooxygenase
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          • AGY49584.1
          • pbtX
          		 10422 - 11069 (+) hypothetical protein
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            • AGY49585.1
            • pbtM1
            		 11114 - 12232 (+) N-methyltransferase
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              • AGY49586.1
              • pbtM2
              		 12307 - 13491 (+) radical SAM
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                • AGY49587.1
                • pbtA
                		 13617 - 13784 (+) precursor peptide
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                  • AGY49588.1
                  • pbtB
                  		 13842 - 16331 (+) dehydratase (serine dehydration)
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                    • AGY49589.1
                    • pbtC
                    		 16324 - 17232 (+) dehydratase (serine dehydration)
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                      • AGY49590.1
                      • pbtD
                      		 17213 - 18214 (+) [4 + 2] cycloaddition
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                        • AGY49591.1
                        • pbtE
                        		 18214 - 19584 (+) azoline-synthesizing dehydrogenase
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                          • AGY49592.1
                          • pbtF
                          		 19572 - 21368 (+) hypothetical protein
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                            • AGY49593.1
                            • pbtG
                            		 21368 - 23104 (+) cyclodehydratase
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                              • AGY49594.1
                              • pbtH
                              		 23121 - 23489 (+) hypothetical
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                                • AGY49595.1
                                • pbtM3
                                		 23539 - 24705 (+) radical SAM
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                                  • AGY49596.1
                                  • pbtM4
                                  		 24715 - 25722 (+) O-methyltransferase
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                                    Biosynthesis information
                                    Annotation changelog

                                    Entry version: next

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2024-03-19
                                    MIBiG v4 annotathon
                                    • (ID: DPAKSDGGIIU3JRGIDNMS7RSG)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 4

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-10-07
                                    Update chemical activity to schema version 2.11
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 3

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-09-15
                                    Refined reference coordinates
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 2

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2019-10-16
                                    Migrated from v1.4
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 1

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2015-06-12
                                    Submitted
                                    • (ID: LOOLDPJUN4VZBEJ3W5R2EHIG)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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