BGC0001155: GE2270 biosynthetic gene cluster from Planobispora rosea
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Location: 4,201 - 25,722 nt. (total: 21,522 nt).
This entry is originally from NCBI GenBank KF366381.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
RiPP
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001155
Short description GE2270 biosynthetic gene cluster from Planobispora rosea
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • RiPP (Thiopeptide)
Loci NCBI GenBank: KF366381.2
Compounds
  • GE2270
Species Planobispora rosea [taxonomy]
References
Chemical products information
GE2270
Copy SMILES
C56H55N15O10S6
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGY49580.1
  • pbtR
 4301 - 5014 (+) TetR transcriptional regulator
  • Regulation
Sequence-based prediction
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  • AGY49581.1
  • pbtG1
 5068 - 6891 (+) cyclodehydratase (oxazoline formation)
  • Scaffold biosynthesis
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  • AGY49582.1
  • pbtB1
 6888 - 9266 (+) dehydratase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AGY49583.1
  • pbtO
 9263 - 10297 (+) P450 monooxygenase
  • Tailoring (Hydroxylation)
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  • AGY49584.1
  • pbtX
 10422 - 11069 (+) hypothetical protein
  • Unknown
Sequence-based prediction
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  • AGY49585.1
  • pbtM1
 11114 - 12232 (+) N-methyltransferase
  • Tailoring (Methylation)
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  • AGY49586.1
  • pbtM2
 12307 - 13491 (+) radical SAM
  • Tailoring (Methylation)
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  • AGY49587.1
  • pbtA
 13617 - 13784 (+) precursor peptide
  • Scaffold biosynthesis
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  • AGY49588.1
  • pbtB
 13842 - 16331 (+) dehydratase (serine dehydration)
  • Scaffold biosynthesis
Sequence-based prediction
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  • AGY49589.1
  • pbtC
 16324 - 17232 (+) dehydratase (serine dehydration)
  • Scaffold biosynthesis
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  • AGY49590.1
  • pbtD
 17213 - 18214 (+) [4 + 2] cycloaddition
  • Scaffold biosynthesis
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  • AGY49591.1
  • pbtE
 18214 - 19584 (+) azoline-synthesizing dehydrogenase
  • Scaffold biosynthesis
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  • AGY49592.1
  • pbtF
 19572 - 21368 (+) hypothetical protein
  • Scaffold biosynthesis
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  • AGY49593.1
  • pbtG
 21368 - 23104 (+) cyclodehydratase
  • Scaffold biosynthesis
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  • AGY49594.1
  • pbtH
 23121 - 23489 (+) hypothetical
  • Tailoring (Unknown)
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  • AGY49595.1
  • pbtM3
 23539 - 24705 (+) radical SAM
  • Tailoring (Methylation)
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  • AGY49596.1
  • pbtM4
 24715 - 25722 (+) O-methyltransferase
  • Tailoring (Methylation)
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RiPP-specific information
Subclass Thiopeptide
Cyclic? yes
Precursor genes
pbtA
Leader sequence: MSEMELNLNDLPMDVFEMADSGMEVESLTAGHGMPEVGA
Core sequences:
  • SCNCVCGFCCSCSPSA
Crosslinks:
  • 1x11 (Unknown)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: LOOLDPJUN4VZBEJ3W5R2EHIG, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Refined reference coordinates
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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