BGC0001159: marinopyrrole A biosynthetic gene cluster from Streptomyces sp. CNQ-418
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Location: 1 - 43,083 nt. (total: 43,083 nt).
This entry is originally from NCBI GenBank JX157625.1.

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core biosynthetic genes
additional biosynthetic genes
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001159
Short description marinopyrrole A biosynthetic gene cluster from Streptomyces sp. CNQ-418
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: JX157625.1
Compounds
  • marinopyrrole A
  • marinopyrrole E
  • marinopyrrole D
  • marinopyrrole C
  • marinopyrrole B
Species Streptomyces sp. CNQ-418 [taxonomy]
References
Chemical products information
marinopyrrole A
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C22H12Cl4N2O4
Chemical database entries
NPAtlas
marinopyrrole E
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C22H11Br1Cl4N2O4
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NPAtlas
marinopyrrole D
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C22H11Cl5N2O4
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NPAtlas
marinopyrrole C
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C22H11Cl5N2O4
Chemical database entries
NPAtlas
marinopyrrole B
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C22H11Br1Cl4N2O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFP87514.1
 10 - 540 (-) chloramphenicol 3-O-phosphotransferase
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  • AFP87515.1
 1003 - 1686 (+) hypothetical protein
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  • AFP87516.1
 1790 - 3760 (-) hsp90-like protein
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  • AFP87517.1
 4167 - 5111 (+) oxidoreductase
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  • AFP87518.1
  • mpy1
 5310 - 5858 (-) flavin reductase
  • Unknown
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  • AFP87519.1
  • mpy2
 5855 - 7486 (-) proline adenyltransferase
  • Precursor biosynthesis
Sequence-based prediction
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  • AFP87520.1
  • mpy3
 7483 - 8622 (-) acyl-CoA dehydrogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • AFP87521.1
  • mpy4
 8664 - 10034 (-) sodium/hydrogen exchanger
  • Transport
Sequence-based prediction
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  • AFP87522.1
  • mpy5
 10031 - 11785 (-) FADH2-dependent halogenase
  • Unknown
Sequence-based prediction
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  • AFP87523.1
  • mpy6
 11817 - 18584 (-) type I polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AFP87524.1
  • mpy7
 18581 - 25324 (-) type I polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AFP87525.1
  • mpy8
 25414 - 26448 (+) 4'-phosphopantetheinyl transferase
  • Activation / processing
Sequence-based prediction
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  • AFP87526.1
  • mpy9
 26451 - 27299 (+) type II thioesterase
  • Activation / processing
Sequence-based prediction
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  • AFP87527.1
  • mpy10
 27470 - 29218 (+) FADH2-dependent halogenase
  • Tailoring (Halogenation)
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  • AFP87528.1
  • mpy11
 29258 - 30928 (+) FADH2-dependent halogenase
  • Tailoring (Halogenation)
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  • AFP87529.1
  • mpy12
 30954 - 31694 (+) ABC transporter
  • Transport
Sequence-based prediction
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  • AFP87530.1
  • mpy13
 31744 - 32481 (+) ABC transporter
  • Transport
Sequence-based prediction
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  • AFP87531.1
  • mpy14
 32513 - 33253 (+) ABC transporter
  • Transport
Sequence-based prediction
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  • AFP87532.1
  • mpy15
 33367 - 33633 (+) proline carrier protein
  • Activation / processing
Sequence-based prediction
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  • AFP87533.1
  • mpy16
 33648 - 34991 (+) FADH2-dependent halogenase
  • Precursor biosynthesis
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  • AFP87534.1
 35095 - 36966 (+) 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit
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  • AFP87535.1
 36950 - 38041 (+) 2-oxoglutarate ferredoxin oxidoreductase, beta subunit
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  • AFP87536.1
 38253 - 38882 (-) TetR family transcriptional regulator
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  • AFP87537.1
 39320 - 41113 (-) hypothetical protein
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  • AFP87538.1
 41838 - 43067 (+) transposase
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Polyketide-specific information
Subclass Other
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
mpy6
+
mpy7
+
mpy9
+
mpy6 		Synthase subclass: Modular type I
Thioesterases:
  • mpy6 (Unknown)
  • mpy9 (Unknown)
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: mpy7
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: mpy7
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: mpy6
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP), Thioesterase
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass N/A
Cyclic? no
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: UJYWT4SZRXDY2IOPYAIF6MII, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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