BGC0001165: curacin A biosynthetic gene cluster from Lyngbya majuscula
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Location: 1 - 87,427 nt. (total: 87,427 nt).
This entry is originally from NCBI GenBank AY652953.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001165
Short description curacin A biosynthetic gene cluster from Lyngbya majuscula
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
AY652953.1
via Enzymatic assays, Gene expression correlated with compound production
Compounds
  • curacin A
Species Lyngbya majuscula [taxonomy]
References
Chemical products information
curacin A Evidence:
Copy SMILES
C23H35N1O1S1
Chemical database entries
PubCHEM
ChEBI
ChEMBL
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAT70096.1
  • curA
 11137 - 18072 (+) CurA
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    • AAT70097.1
    • curB
    		 18091 - 18330 (+) CurB
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      • AAT70098.1
      • curC
      		 18382 - 19608 (+) CurC
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        • AAT70099.1
        • curD
        		 19544 - 20872 (+) CurD
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          • AAT70100.1
          • curE
          		 21129 - 21893 (+) CurE
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            • AAT70101.1
            • curF
            		 21881 - 31468 (+) CurF
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              • AAT70102.1
              • curG
              		 31556 - 36307 (+) CurG
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                • AAT70103.1
                • curH
                		 36316 - 42915 (+) CurH
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                  • AAT70104.1
                  • curI
                  		 42915 - 47885 (+) CurI
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                    • AAT70105.1
                    • curJ
                    		 47953 - 54849 (+) CurJ
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                      • AAT70106.1
                      • curK
                      		 54908 - 61606 (+) CurK
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                        • AAT70107.1
                        • curL
                        		 61691 - 67561 (+) CurL
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                          • AAT70108.1
                          • curM
                          		 67564 - 74007 (+) CurM
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                            • AAT70109.1
                            • curN
                            		 73814 - 74839 (+) CurN
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                              Biosynthesis information

                              Biosynthetic modules

                              Name
                              Unk01
                              Type
                              nrps-type1
                              Genes
                              curF
                              Substrates
                              cysteine (evidence: )
                              Integrated Monomers
                              Domains
                              condensation (Heterocyclization), adenylation
                              Name
                              0
                              Type
                              pks-modular-starter
                              Genes
                              curA
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, carrier (ACP)
                              Name
                              1
                              Type
                              pks-modular
                              Genes
                              curA
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, oxidase, carrier (ACP), carrier (ACP), carrier (ACP)
                              Name
                              2
                              Type
                              pks-modular
                              Genes
                              curF
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, enoylreductase, carrier (ACP)
                              Name
                              3
                              Type
                              pks-modular
                              Genes
                              curG
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                              Name
                              4
                              Type
                              pks-modular
                              Genes
                              curH
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, enoylreductase, dehydratase, ketoreductase, carrier (ACP)
                              Name
                              5
                              Type
                              pks-modular
                              Genes
                              curI
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, methyltransferase, carrier (ACP)
                              Name
                              6
                              Type
                              pks-modular
                              Genes
                              curJ
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, enoylreductase, dehydratase, ketoreductase, carrier (ACP)
                              Name
                              7
                              Type
                              pks-modular
                              Genes
                              curK
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, ketoreductase, methyltransferase, carrier (ACP)
                              Name
                              8
                              Type
                              pks-modular
                              Genes
                              curL
                              Substrates
                              Integrated Monomers
                              Domains
                              acyltransferase, ketosynthase, acyltransferase, ketoreductase, thioesterase, carrier (ACP)
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2022-09-15
                              Added NRP substrate specificities
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2015-06-12
                              Submitted
                              • (ID: SGC7EMZRHSTY2JHRE5IDTTEF)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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