BGC0001165: curacin A biosynthetic gene cluster from Lyngbya majuscula
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Location: 1 - 87,427 nt. (total: 87,427 nt).
This entry is originally from NCBI GenBank AY652953.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001165
Short description curacin A biosynthetic gene cluster from Lyngbya majuscula
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: AY652953.1
Compounds
  • curacin A
Species Lyngbya majuscula [taxonomy]
References
Chemical products information
curacin A
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C23H35N1O1S1
Chemical database entries
PubCHEM
ChEBI
ChEMBL
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAT70096.1
  • curA
 11137 - 18072 (+) CurA
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  • AAT70097.1
  • curB
 18091 - 18330 (+) CurB
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  • AAT70098.1
  • curC
 18382 - 19608 (+) CurC
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  • AAT70099.1
  • curD
 19544 - 20872 (+) CurD
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  • AAT70100.1
  • curE
 21129 - 21893 (+) CurE
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  • AAT70101.1
  • curF
 21881 - 31468 (+) CurF
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  • AAT70102.1
  • curG
 31556 - 36307 (+) CurG
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  • AAT70103.1
  • curH
 36316 - 42915 (+) CurH
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  • AAT70104.1
  • curI
 42915 - 47885 (+) CurI
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  • AAT70105.1
  • curJ
 47953 - 54849 (+) CurJ
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  • AAT70106.1
  • curK
 54908 - 61606 (+) CurK
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  • AAT70107.1
  • curL
 61691 - 67561 (+) CurL
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  • AAT70108.1
  • curM
 67564 - 74007 (+) CurM
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  • AAT70109.1
  • curN
 73814 - 74839 (+) CurN
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Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
curM
+
curG
+
curF
+
curH
+
curJ
+
curA
+
curK
+
curL
+
curI 		Synthase subclass: Modular type I
Thioesterases:
  • curM (Unknown)
Module 0
Specificity: Malonyl-CoA
Genes: curA
Core domains: Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Malonyl-CoA
Genes: curA
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP), Thiolation (ACP/PCP), Thiolation (ACP/PCP)
Scaffold-modifying domains: Oxidation
Module 2
Specificity: Cyclohexylcarbonyl-CoA
Genes: curF
Core domains: Enoylreductase, Ketosynthase, Acyltransferase, Thiolation (ACP/PCP), Condensation, Adenlyation, Thiolation (ACP/PCP)
Module 3
Specificity: Malonyl-CoA
Genes: curG
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Specificity: Malonyl-CoA
Genes: curH
Core domains: Ketosynthase, Acyltransferase, Enoylreductase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Specificity: Malonyl-CoA
Genes: curI
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 6
Specificity: Malonyl-CoA
Genes: curJ
Core domains: Ketosynthase, Acyltransferase, Enoylreductase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Specificity: Malonyl-CoA
Genes: curK
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 8
Specificity: Malonyl-CoA
Genes: curL
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP), Thioesterase
KR-domain stereochemistry: Unknown
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
curF
Module ?
Specificity: cysteine
Evidence for specificity:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: SGC7EMZRHSTY2JHRE5IDTTEF, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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