BGC0001189: taiwachelin biosynthetic gene cluster from Cupriavidus taiwanensis LMG 19424
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Location: 1,259,880 - 1,338,651 nt. (total: 78,772 nt).
This entry is originally from NCBI GenBank CU633750.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001189
Short description taiwachelin biosynthetic gene cluster from Cupriavidus taiwanensis LMG 19424
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
CU633750.1
1278232 - 1320161
via
Compounds
  • taiwachelin
Species Cupriavidus taiwanensis LMG 19424 [taxonomy]
References
Chemical products information
taiwachelin Evidence:
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C41H70N8O18
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RALTA_B1222
  • CAQ71823.1
 1278232 - 1278648 (+) putative cyclase/dehydrase; putatively involved in polyketide (linear poly-beta-ketones) synthesis; antibiotic biosynthesis
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    • RALTA_B1223
    • CAQ71824.1
    		 1278865 - 1279086 (+) conserved hypothetical protein, mbtH-like
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      • RALTA_B1224
      • CAQ71825.1
      • lgrE
      		 1279089 - 1279823 (+) Linear gramicidin dehydrogenase, type II thioesterase
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        • RALTA_B1225
        • CAQ71826.1
        		 1279880 - 1284400 (+) non ribosomal peptide synthase, antibiotic synthesis; contains 1 condensation domain, 1 AMP-acid ligases II domain, PP-binding, Phosphopantetheine attachment site and one taurine catabolism dioxygenase
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          • RALTA_B1226
          • CAQ71827.1
          		 1284405 - 1287584 (+) non ribosomal peptide synthase, antibiotic synthesis; contains 1 condensation domain, 1 AMP-acid ligases II domain
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            • RALTA_B1227
            • CAQ71828.1
            		 1287609 - 1295399 (+) non ribosomal peptide synthase, antibiotic synthesis; contains 3 condensation domains, 2 AMP-acid ligases II domains, 2 PP-binding, Phosphopantetheine attachment site
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              • RALTA_B1228
              • CAQ71829.1
              		 1295400 - 1307267 (+) non ribosomal peptide synthase, antibiotic synthesis; contains 4 condensation domains, 3 AMP-acid ligases II domains, 3 PP-binding, Phosphopantetheine attachment site and a putative thioesterase domain
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                • RALTA_B1229
                • CAQ71830.1
                • fhuA2
                		 1307357 - 1309573 (+) TonB-dependent siderophore receptor, HYDROXAMATE-TYPE FERRISIDEROPHORE RECEPTOR precursor
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                  • RALTA_B1230
                  • CAQ71831.1
                  		 1309652 - 1310830 (+) conserved hypothetical protein; putative Membrane protein; DUF337,Uncharacterized iron-regulated membrane protein
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                    • RALTA_B1231
                    • CAQ71832.1
                    		 1310827 - 1311021 (+) hypothetical protein; putative exported protein
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                      • RALTA_B1232
                      • CAQ71833.1
                      		 1310963 - 1311754 (-) putative reductase; Uncharacterized Fe-S protein
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                        • RALTA_B1233
                        • ISRta4-p
                        		 1312202 - 1312936 (-) Transposase fragment, IS1111 family
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                          • RALTA_B1234
                          • CAQ71835.1
                          • yojI
                          		 1313460 - 1315100 (+) ABC transporter ATP-binding protein, putative ABC-type siderophore export system
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                            • RALTA_B1235
                            • CAQ71836.1
                            		 1315097 - 1316152 (+) putative ESTERASE/LIPASE PROTEIN
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                              • RALTA_B1236
                              • CAQ71837.1
                              • iucB
                              		 1316214 - 1317296 (+) siderophore biosynthesis protein, putative acetyltransferase
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                                • RALTA_B1237
                                • CAQ71838.1
                                • iucD
                                		 1317293 - 1318651 (+) L-ornithine 5-monooxygenase(L-ornithine N5-oxygenase) L-lysine 6-monooxygenase (Lysine N(6)-hydroxylase); Siderophore biosynthesis protein
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                                  • RALTA_B1238
                                  • CAQ71839.1
                                  		 1318615 - 1319403 (-) 4'-phosphopantetheinyl transferase
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                                    • RALTA_B1239
                                    • CAQ71840.1
                                    		 1319583 - 1320161 (+) RNA polymerase sigma factor
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                                      Biosynthesis information

                                      Biosynthetic modules

                                      Name
                                      Unk01
                                      Type
                                      nrps-type1
                                      Genes
                                      RALTA_B1226
                                      Substrates
                                      aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk02
                                      Type
                                      nrps-type1
                                      Genes
                                      RALTA_B1227
                                      Substrates
                                      threonine (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk03
                                      Type
                                      nrps-type1
                                      Genes
                                      RALTA_B1227
                                      Substrates
                                      aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk04
                                      Type
                                      nrps-type1
                                      Genes
                                      RALTA_B1228
                                      Substrates
                                      ornithine (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk05
                                      Type
                                      nrps-type1
                                      Genes
                                      RALTA_B1228
                                      Substrates
                                      serine (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Name
                                      Unk06
                                      Type
                                      nrps-type1
                                      Genes
                                      RALTA_B1228
                                      Substrates
                                      ornithine (evidence: Structure-based inference, Sequence-based prediction)
                                      Integrated Monomers
                                      Domains
                                      adenylation
                                      Annotation changelog

                                      Entry version: 4

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-10-07
                                      Update chemical activity to schema version 2.11
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 3

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2022-09-15
                                      Updated bioactivity data
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2022-09-15
                                      Added NRP substrate specificities
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 2

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2019-10-16
                                      Migrated from v1.4
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      2019-10-16
                                      Updated compound(s) information (NPAtlas curation)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                      Entry version: 1

                                      Date
                                      Changes
                                      Submitters
                                      Reviewers
                                      2015-08-17
                                      Submitted
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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