BGC0001189: taiwachelin biosynthetic gene cluster from Cupriavidus taiwanensis LMG 19424
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Location: 1,278,232 - 1,320,161 nt. (total: 41,930 nt).
This entry is originally from NCBI GenBank CU633750.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001189
Short description taiwachelin biosynthetic gene cluster from Cupriavidus taiwanensis LMG 19424
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: CU633750.1
Compounds
  • taiwachelin
Species Cupriavidus taiwanensis LMG 19424 [taxonomy]
References
Chemical products information
taiwachelin
Copy SMILES
C41H70N8O18
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RALTA_B1222
  • CAQ71823.1
 1278232 - 1278648 (+) putative cyclase/dehydrase; putatively involved in polyketide (linear poly-beta-ketones) synthesis; antibiotic biosynthesis
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  • RALTA_B1223
  • CAQ71824.1
 1278865 - 1279086 (+) conserved hypothetical protein, mbtH-like
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  • RALTA_B1224
  • CAQ71825.1
  • lgrE
 1279089 - 1279823 (+) Linear gramicidin dehydrogenase, type II thioesterase
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  • RALTA_B1225
  • CAQ71826.1
 1279880 - 1284400 (+) non ribosomal peptide synthase, antibiotic synthesis; contains 1 condensation domain, 1 AMP-acid ligases II domain, PP-binding, Phosphopantetheine attachment site and one taurine catabolism dioxygenase
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  • RALTA_B1226
  • CAQ71827.1
 1284405 - 1287584 (+) non ribosomal peptide synthase, antibiotic synthesis; contains 1 condensation domain, 1 AMP-acid ligases II domain
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  • RALTA_B1227
  • CAQ71828.1
 1287609 - 1295399 (+) non ribosomal peptide synthase, antibiotic synthesis; contains 3 condensation domains, 2 AMP-acid ligases II domains, 2 PP-binding, Phosphopantetheine attachment site
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  • RALTA_B1228
  • CAQ71829.1
 1295400 - 1307267 (+) non ribosomal peptide synthase, antibiotic synthesis; contains 4 condensation domains, 3 AMP-acid ligases II domains, 3 PP-binding, Phosphopantetheine attachment site and a putative thioesterase domain
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  • RALTA_B1229
  • CAQ71830.1
  • fhuA2
 1307357 - 1309573 (+) TonB-dependent siderophore receptor, HYDROXAMATE-TYPE FERRISIDEROPHORE RECEPTOR precursor
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  • RALTA_B1230
  • CAQ71831.1
 1309652 - 1310830 (+) conserved hypothetical protein; putative Membrane protein; DUF337,Uncharacterized iron-regulated membrane protein
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  • RALTA_B1231
  • CAQ71832.1
 1310827 - 1311021 (+) hypothetical protein; putative exported protein
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  • RALTA_B1232
  • CAQ71833.1
 1310963 - 1311754 (-) putative reductase; Uncharacterized Fe-S protein
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  • RALTA_B1233
  • ISRta4-p
 1312202 - 1312936 (-) Transposase fragment, IS1111 family
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  • RALTA_B1234
  • CAQ71835.1
  • yojI
 1313460 - 1315100 (+) ABC transporter ATP-binding protein, putative ABC-type siderophore export system
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  • RALTA_B1235
  • CAQ71836.1
 1315097 - 1316152 (+) putative ESTERASE/LIPASE PROTEIN
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  • RALTA_B1236
  • CAQ71837.1
  • iucB
 1316214 - 1317296 (+) siderophore biosynthesis protein, putative acetyltransferase
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  • RALTA_B1237
  • CAQ71838.1
  • iucD
 1317293 - 1318651 (+) L-ornithine 5-monooxygenase(L-ornithine N5-oxygenase) L-lysine 6-monooxygenase (Lysine N(6)-hydroxylase); Siderophore biosynthesis protein
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  • RALTA_B1238
  • CAQ71839.1
 1318615 - 1319403 (-) 4'-phosphopantetheinyl transferase
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  • RALTA_B1239
  • CAQ71840.1
 1319583 - 1320161 (+) RNA polymerase sigma factor
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
RALTA_B1226
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
RALTA_B1227
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
RALTA_B1228
Module ?
Specificity: ornithine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: ornithine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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