BGC0001233: feglymycin biosynthetic gene cluster from Streptomyces sp. DSM 11171
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Location: 1 - 72,176 nt. (total: 72,176 nt).
This entry is originally from NCBI GenBank KT809366.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001233
Short description feglymycin biosynthetic gene cluster from Streptomyces sp. DSM 11171
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
KT809366.1
via
Compounds
  • feglymycin
Species Streptomyces sp. DSM 11171 [taxonomy]
References
Chemical products information
feglymycin Evidence:
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C95H97N13O30
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ALK27898.1
  • fegA
 1 - 1068 (+) putative 3-deoxy-D-arabinoseheptulosonate 7-phosphate synthase
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    • ALK27899.1
    • fegB
    		 1431 - 2438 (+) putative transcriptional regulator
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      • ALK27900.1
      • fegC
      		 2638 - 3777 (-) hydroxymandelate oxidase
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        • ALK27901.1
        • fegD
        		 3761 - 4861 (-) putative hydroxymandelate synthase
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          • ALK27902.1
          • fegE
          		 5029 - 6225 (+) putative prephenate dehydrogenase
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            • ALK27903.1
            • fegF
            		 6554 - 9463 (+) putative LuxR regulatory protein
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              • ALK27904.1
              • fegG
              		 9603 - 11930 (+) putative hydroxyphenylglycine aminotransferase/hydroxymandelate oxidase fusion protein
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                • ALK27905.1
                • fegH
                		 12002 - 13168 (+) putative 3,5-dihydroxyphenylacetyl-CoA Synthetase
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                  • ALK27906.1
                  • fegI
                  		 13192 - 13845 (+) putative enoyl-CoA hydratase
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                    • ALK27907.1
                    • fegJ
                    		 13842 - 15149 (+) putative 3,5-dihydroxyphenylacetyl-CoA oxygenase
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                      • ALK27908.1
                      • fegK
                      		 15146 - 15958 (+) putative enoyl-CoA hydratase
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                        • ALK27909.1
                        • fegL
                        		 16221 - 17030 (+) putative alpha/beta hydrolase
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                          • ALK27910.1
                          • fegM
                          		 17050 - 18306 (-) putative histidine kinase
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                            • ALK27911.1
                            • fegN
                            		 18314 - 18967 (-) putative two component transcription regulator
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                              • ALK27912.1
                              • fegO
                              		 19297 - 19521 (+) putative antibiotic synthesis protein MbtH
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                                • ALK27913.1
                                • fegP
                                		 19602 - 21659 (+) putative ABC transporter
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                                  • ALK27914.1
                                  • fegQ
                                  		 21744 - 38087 (+) non-ribosomal peptide synthase
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                                    • ALK27915.1
                                    • fegR
                                    		 38216 - 61951 (+) non-ribosomal peptide synthase
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                                      • ALK27916.1
                                      • fegS
                                      		 61953 - 72176 (+) non-ribosomal peptide synthase
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                                        Biosynthesis information

                                        Biosynthetic modules

                                        Name
                                        Unk01
                                        Type
                                        nrps-type1
                                        Genes
                                        fegQ
                                        Substrates
                                        4-hydroxyphenylglycine (evidence: Structure-based inference [1])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk02
                                        Type
                                        nrps-type1
                                        Genes
                                        fegQ
                                        Substrates
                                        3,5-dihydroxyphenylglycine (evidence: Structure-based inference [1])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk03
                                        Type
                                        nrps-type1
                                        Genes
                                        fegQ
                                        Substrates
                                        valine (evidence: Structure-based inference, Sequence-based prediction)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk04
                                        Type
                                        nrps-type1
                                        Genes
                                        fegQ
                                        Substrates
                                        3,5-dihydroxyphenylglycine (evidence: Structure-based inference [1])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk05
                                        Type
                                        nrps-type1
                                        Genes
                                        fegR
                                        Substrates
                                        4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk06
                                        Type
                                        nrps-type1
                                        Genes
                                        fegR
                                        Substrates
                                        3,5-dihydroxyphenylglycine (evidence: Structure-based inference [1])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk07
                                        Type
                                        nrps-type1
                                        Genes
                                        fegR
                                        Substrates
                                        4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk08
                                        Type
                                        nrps-type1
                                        Genes
                                        fegR
                                        Substrates
                                        3,5-dihydroxyphenylglycine (evidence: Structure-based inference [1])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk09
                                        Type
                                        nrps-type1
                                        Genes
                                        fegR
                                        Substrates
                                        valine (evidence: Structure-based inference, Sequence-based prediction)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk10
                                        Type
                                        nrps-type1
                                        Genes
                                        fegR
                                        Substrates
                                        3,5-dihydroxyphenylglycine (evidence: Structure-based inference [1])
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk11
                                        Type
                                        nrps-type1
                                        Genes
                                        fegS
                                        Substrates
                                        4-hydroxyphenylglycine (evidence: Structure-based inference, Sequence-based prediction)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk12
                                        Type
                                        nrps-type1
                                        Genes
                                        fegS
                                        Substrates
                                        phenylalanine (evidence: Structure-based inference, Sequence-based prediction)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Name
                                        Unk13
                                        Type
                                        nrps-type1
                                        Genes
                                        fegS
                                        Substrates
                                        aspartic acid (evidence: Structure-based inference, Sequence-based prediction)
                                        Integrated Monomers
                                        Domains
                                        adenylation
                                        Annotation changelog

                                        Entry version: 4

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-10-07
                                        Update chemical activity to schema version 2.11
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 3

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2022-09-15
                                        Updated bioactivity data
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2022-09-15
                                        Added NRP substrate specificities
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 2

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2019-10-16
                                        Migrated from v1.4
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2019-10-16
                                        Updated reference publication(s) (MIBiG Annotathon)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        2019-10-16
                                        Updated compound(s) information (NPAtlas curation)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                        Entry version: 1

                                        Date
                                        Changes
                                        Submitters
                                        Reviewers
                                        2015-12-24
                                        Submitted
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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