BGC0001283: Bisenarsan biosynthetic gene cluster from Streptomyces lividans 1326
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1,080,808 - 1,113,162 nt. (total: 32,355 nt).
This entry is originally from NCBI GenBank NZ_CM001889.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001283
Short description Bisenarsan biosynthetic gene cluster from Streptomyces lividans 1326
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The actual structures of these products are still subject to further investigation and will be discussed in detail in a future publication. "
Biosynthetic class(es)
  • PKS (Type I)
Loci
NZ_CM001889.1
1080808 - 1113162
via Knock-out studies, Gene expression correlated with compound production
Compounds
  • Bisenarsan
Species Streptomyces lividans 1326 [taxonomy]
References
Chemical products information
Bisenarsan Evidence: NMR [1]
Copy SMILES
C15H28As1O3
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SLI_RS05010
  • WP_016325493.1
 1081206 - 1081619 (+) arsenate reductase ArsC
    copy AA seq
    copy Nt seq
    • SLI_RS05015
    • WP_016325494.1
    • trxB
    		 1081616 - 1082608 (+) thioredoxin-disulfide reductase
      copy AA seq
      copy Nt seq
      • SLI_RS05020
      • WP_016325495.1
      		 1082697 - 1083119 (-) cobalamin B12-binding domain-containing protein
        copy AA seq
        copy Nt seq
        • SLI_RS05025
        • WP_016325496.1
        		 1083162 - 1084757 (-) methylmalonyl-CoA mutase family protein
          copy AA seq
          copy Nt seq
          • SLI_RS05030
          • WP_016325497.1
          		 1084813 - 1085088 (-) DUF5988 family protein
            copy AA seq
            copy Nt seq
            • SLI_RS05035
            • WP_042799404.1
            		 1085582 - 1085935 (-) metalloregulator ArsR/SmtB family transcription factor
              copy AA seq
              copy Nt seq
              • SLI_RS05040
              • WP_042799405.1
              		 1086020 - 1086799 (+) SDR family NAD(P)-dependent oxidoreductase
                copy AA seq
                copy Nt seq
                • SLI_RS05045
                • WP_016325500.1
                		 1086860 - 1088341 (-) NAD(P)-binding domain-containing protein
                  copy AA seq
                  copy Nt seq
                  • SLI_RS41050
                  • WP_016325501.1
                  		 1088377 - 1088538 (-) hypothetical protein
                    copy AA seq
                    copy Nt seq
                    • SLI_RS05050
                    • WP_042799407.1
                    		 1089037 - 1096113 (+) type I polyketide synthase
                      copy AA seq
                      copy Nt seq
                      • SLI_RS05055
                      • WP_007445820.1
                      		 1096140 - 1097180 (+) ketoacyl-ACP synthase III family protein
                        copy AA seq
                        copy Nt seq
                        • SLI_RS05060
                        • WP_016325503.1
                        		 1097289 - 1097960 (+) VTT domain-containing protein
                          copy AA seq
                          copy Nt seq
                          • SLI_RS05065
                          • WP_016325504.1
                          • aepY
                          		 1097957 - 1099060 (+) phosphonopyruvate decarboxylase
                            copy AA seq
                            copy Nt seq
                            • SLI_RS05070
                            • WP_016325505.1
                            		 1099136 - 1099537 (-) metalloregulator ArsR/SmtB family transcription factor
                              copy AA seq
                              copy Nt seq
                              • SLI_RS05075
                              • WP_016325506.1
                              		 1099606 - 1101171 (-) MFS transporter
                                copy AA seq
                                copy Nt seq
                                • SLI_RS05080
                                • WP_042799411.1
                                		 1101916 - 1102638 (+) CTP synthase
                                  copy AA seq
                                  copy Nt seq
                                  • SLI_RS05085
                                  • WP_016325508.1
                                  		 1102749 - 1105271 (+) molybdopterin-dependent oxidoreductase
                                    copy AA seq
                                    copy Nt seq
                                    • SLI_RS05090
                                    • WP_016325509.1
                                    • aroA
                                    		 1105327 - 1106649 (+) 3-phosphoshikimate 1-carboxyvinyltransferase
                                      copy AA seq
                                      copy Nt seq
                                      • SLI_RS05095
                                      • WP_016325510.1
                                      • gpmI
                                      		 1106646 - 1108181 (+) 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
                                        copy AA seq
                                        copy Nt seq
                                        • SLI_RS05100
                                        • WP_016325511.1
                                        		 1108178 - 1108537 (+) hypothetical protein
                                          copy AA seq
                                          copy Nt seq
                                          • SLI_RS05105
                                          • WP_016325512.1
                                          		 1108858 - 1109730 (+) phosphate ABC transporter substrate-binding protein
                                            copy AA seq
                                            copy Nt seq
                                            • SLI_RS05110
                                            • WP_016325513.1
                                            • pstC
                                            		 1109734 - 1111545 (+) phosphate ABC transporter permease subunit PstC
                                              copy AA seq
                                              copy Nt seq
                                              • SLI_RS05115
                                              • WP_042799412.1
                                              		 1111533 - 1112222 (+) ATP-binding cassette domain-containing protein
                                                copy AA seq
                                                copy Nt seq
                                                • SLI_RS05120
                                                • WP_042799413.1
                                                		 1112344 - 1112685 (-) metalloregulator ArsR/SmtB family transcription factor
                                                  copy AA seq
                                                  copy Nt seq
                                                  • SLI_RS05125
                                                  • WP_007445854.1
                                                  		 1112803 - 1113162 (-) metalloregulator ArsR/SmtB family transcription factor
                                                    copy AA seq
                                                    copy Nt seq
                                                    Biosynthesis information
                                                    Annotation changelog

                                                    Entry version: next

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2024-05-28
                                                    MIBiG v4 annotathon
                                                    • (ID: VN4WQJSSFIJHEVCKX4HDODAG)
                                                    • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 2

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2019-10-16
                                                    Migrated from v1.4
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 1

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2015-12-24
                                                    Submitted
                                                    • (ID: YFQE6LBJ4VCTUO2RYKJB5QD7)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    Detailed domain annotation
                                                    Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                    A domain glossary is available here, and an explanation of the visualisation is available here.
                                                    Selected features only
                                                    Show module domains
                                                    Similar known gene clusters from MIBiG 4.0
                                                    Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                    Click on reference genes to show details of similarities to genes within the current region.
                                                    Click on an accession to open that entry in the MiBIG database.