BGC0001287: chaxamycin A biosynthetic gene cluster from Streptomyces leeuwenhoekii
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Location: 1,211,049 - 1,305,927 nt. (total: 94,879 nt).
This entry is originally from NCBI GenBank LN831790.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001287
Short description chaxamycin A biosynthetic gene cluster from Streptomyces leeuwenhoekii
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
LN831790.1
1211049 - 1289829
via
Compounds
  • chaxamycin A
  • chaxamycin B
  • chaxamycin C
  • chaxamycin D
Species Streptomyces leeuwenhoekii [taxonomy]
References
Chemical products information
chaxamycin A Evidence:
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C35H45N1O10
Chemical database entries
NPAtlas
PubCHEM
chaxamycin B Evidence:
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C35H45N1O9
Chemical database entries
NPAtlas
PubCHEM
chaxamycin C Evidence:
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C35H45N1O11
Chemical database entries
NPAtlas
PubCHEM
chaxamycin D Evidence:
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C36H45N1O12
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CQR60473.1
  • cxmJ
 1211049 - 1211555 (+) RifJ homologue, AminoDHQ dehydratase, AHBA biosynthesis
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    • CQR60474.1
    • cxmZ
    		 1211584 - 1212324 (-) Transcriptional regulator, atypical response regulator
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      • CQR60475.1
      • cxmY
      		 1212932 - 1214233 (+) LuxR Family Transcriptional Regulator, possible activator; no Rif homologue
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        • CQR60476.1
        • cxmR2
        		 1214242 - 1214403 (-) RifR homologue; Type II thioesterase, probably non-functional
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          • CQR60477.1
          • cxmR
          		 1214471 - 1214728 (-) RifR homologue; Type II thioesterase, probably non-functional
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            • CQR60478.1
            • cxm24
            		 1215239 - 1216306 (+) Methyltransferase SAM-dependent; not homolog to rifamycin Orf14
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              • CQR60479.1
              • cxm23
              		 1216434 - 1217690 (+) Rif-orf5 homologue; Cytochrome P450
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                • CQR60480.1
                • cxm22
                		 1217819 - 1219000 (+) Rif-orf4 homologue; Cytochrome P450
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                  • CQR60481.1
                  • cxm21
                  		 1219014 - 1219205 (+) Ferredoxin 4Fe-4S single cluster domain; no Rif homologue
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                    • CQR60482.1
                    • cxm20
                    		 1219269 - 1220477 (-) Rif-orf20 homologue; O-Acyltransferase
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                      • CQR60483.1
                      • cxm19
                      		 1220780 - 1222381 (+) Rif-orf19 homologue. FDA dependent-monooxygenase; Naphthalene ring formation; 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase
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                        • CQR60484.1
                        • cxm18
                        		 1222473 - 1223360 (+) Rif-orf11 homologue, Flavin-dependent oxidoreductase
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                          • CQR60485.1
                          • cxmN
                          		 1223440 - 1224363 (-) RifN homologue, kanosamine kinase, AHBA biosynthesis
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                            • CQR60486.1
                            • cxmM
                            		 1224368 - 1225066 (-) RifM homologue, phosphoglycolate phosphatase, AHBA biosynthesis
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                              • CQR60487.1
                              • cxmL
                              		 1225100 - 1226176 (-) RifL homologue, oxidoreductase, AHBA biosynthesis
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                                • CQR60488.1
                                • cxmK
                                		 1226173 - 1227333 (-) RifK homologue, 3-amino-5-hydroxy benzoic acid (AHBA) synthase
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                                  • CQR60489.1
                                  • cxmI
                                  		 1227514 - 1228320 (-) RifI homologue, Aminoquinate dehydrogenase, AHBA biosynthesis
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                                    • CQR60490.1
                                    • cxmH
                                    		 1228390 - 1229610 (-) RifH homologue, AminoDAHP synthase, AHBA biosynthesis
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                                      • CQR60491.1
                                      • cxmG
                                      		 1229607 - 1230713 (-) RifG homologue, AminoDHQ synthase, AHBA biosynthesis
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                                        • CQR60492.1
                                        • cxmF
                                        		 1230710 - 1231519 (-) RifF homologue, amide synthase, release of polyketide from PKS and ciclysation
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                                          • CQR60493.1
                                          • cxmE
                                          		 1231564 - 1242030 (-) Polyketide synthase, type I, modules: 9 and 10
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                                            • CQR60494.1
                                            • cxmD
                                            		 1242103 - 1247424 (-) Polyketide synthase, type I, module 8
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                                              • CQR60495.1
                                              • cxmC
                                              		 1247482 - 1252944 (-) Polyketide synthase, type I, module 7
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                                                • CQR60496.1
                                                • cxmB
                                                		 1252955 - 1269046 (-) Polyketide synthase, type I, modules: 4, 5 and 6
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                                                  • CQR60497.1
                                                  • cxmA
                                                  		 1269077 - 1285927 (-) Polyketide synthase, type I, modules: loading, 1, 2 and 3
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                                                    • CQR60498.1
                                                    • cxm4
                                                    		 1285991 - 1287184 (-) Rif-orf0(cero) homologue, Cytochrome P450
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                                                      • CQR60499.1
                                                      • cxmT
                                                      		 1287486 - 1288457 (-) RifT homologue; NAD-dependent oxydoreductase
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                                                        • CQR60500.1
                                                        • cxmS
                                                        		 1288454 - 1289437 (-) RifS homologue; NAD-dependent oxydoreductase
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                                                          • CQR60501.1
                                                          • sle_10390__cxm1
                                                          		 1289413 - 1289829 (-) Hypothetical Protein
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                                                            Biosynthesis information

                                                            No biosynthesis information available for this record.

                                                            Annotation changelog

                                                            Entry version: 4

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-10-07
                                                            Update chemical activity to schema version 2.11
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 3

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-09-15
                                                            Updated bioactivity data
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 2

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2019-10-16
                                                            Migrated from v1.4
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2019-10-16
                                                            Updated compound(s) information (NPAtlas curation)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 1

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2015-12-24
                                                            Submitted
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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