BGC0001303: lobosamide A biosynthetic gene cluster from Micromonospora sp. RL09-050-HVF-A
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Location: 1 - 108,672 nt. (total: 108,672 nt).
This entry is originally from NCBI GenBank KT209587.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001303
Short description lobosamide A biosynthetic gene cluster from Micromonospora sp. RL09-050-HVF-A
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
KT209587.1
via
Compounds
  • lobosamide A
  • lobosamide B
  • lobosamide C
Species Micromonospora sp. RL09-050-HVF-A [taxonomy]
References
Chemical products information
lobosamide A Evidence:
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C29H41N1O5
Chemical database entries
NPAtlas
lobosamide B Evidence:
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C29H41N1O5
Chemical database entries
NPAtlas
lobosamide C Evidence:
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C29H41N1O4
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ALA09339.1
  • ORF1
 419 - 1432 (-) hypothetical protein
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    • ALA09340.1
    • ORF2
    		 1515 - 2462 (-) hypothetical protein
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      • ALA09341.1
      • ORF3
      		 2643 - 3470 (+) hypothetical protein
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        • ALA09342.1
        • ORF4
        		 3452 - 3823 (+) hypothetical protein
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          • ALA09343.1
          • ORF5
          		 3854 - 4882 (+) hypothetical protein
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            • ALA09344.1
            • ORF6
            		 4906 - 5670 (+) hypothetical protein
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              • ALA09345.1
              • ORF7
              		 5843 - 7495 (+) hypothetical protein
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                • ALA09346.1
                • ORF8
                		 8034 - 13499 (-) hypothetical protein
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                  • ALA09347.1
                  • ORF9
                  		 13704 - 14393 (-) hypothetical protein
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                    • ALA09348.1
                    • ORF10
                    		 14510 - 14782 (+) hypothetical protein
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                      • ALA09349.1
                      • ORF11
                      		 14779 - 15792 (+) hypothetical protein
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                        • ALA09350.1
                        • ORF12
                        		 15911 - 16498 (+) hypothetical protein
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                          • ALA09351.1
                          • ORF13
                          		 16699 - 17787 (+) hypothetical protein
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                            • ALA09352.1
                            • ORF14
                            		 17864 - 18082 (+) hypothetical protein
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                              • ALA09353.1
                              • ORF15
                              		 18407 - 19654 (+) hypothetical protein
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                                • ALA09354.1
                                • lobA
                                		 20001 - 25313 (+) type I modular PKS
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                                  • ALA09355.1
                                  • lobB
                                  		 25497 - 34541 (+) type I modular PKS
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                                    • ALA09356.1
                                    • lobC
                                    		 34582 - 39342 (+) type I modular PKS
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                                      • ALA09357.1
                                      • lobD
                                      		 39402 - 48341 (+) type I modular PKS
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                                        • ALA09358.1
                                        • lobE
                                        		 48338 - 52861 (+) type I modular PKS
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                                          • ALA09359.1
                                          • lobF
                                          		 53029 - 55590 (+) type I modular PKS
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                                            • ALA09360.1
                                            • lobG
                                            		 55614 - 56519 (+) peptidase
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                                              • ALA09361.1
                                              • lobH
                                              		 56632 - 57075 (-) transcriptional regulator
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                                                • ALA09362.1
                                                • lobI
                                                		 57151 - 57294 (+) aldo/keto reductase family oxidoreductase
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                                                  • ALA09363.1
                                                  • lobJ
                                                  		 57294 - 58061 (+) aldo/keto reductase family oxidoreductase
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                                                    • ALA09364.1
                                                    • lobK
                                                    		 58127 - 58381 (-) ACP starter unit biosynthesis protein
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                                                      • ALA09365.1
                                                      • lobL
                                                      		 58576 - 60135 (+) AMP-dependent synthetase and ligase
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                                                        • ALA09366.1
                                                        • lobM
                                                        		 60277 - 61821 (-) AMP-dependent synthetase and ligase
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                                                          • ALA09367.1
                                                          • lobN
                                                          		 61847 - 62776 (-) amalonyl CoA-acyl carrier protein transacylase
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                                                            • ALA09368.1
                                                            • lobO
                                                            		 62845 - 64101 (-) aminotransferase
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                                                              • ALA09369.1
                                                              • lobP
                                                              		 64130 - 65476 (-) glutamate 2,3- aminomutase
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                                                                • ALA09370.1
                                                                • lobQ
                                                                		 65834 - 67021 (+) cytochrome P450
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                                                                  • ALA09371.1
                                                                  • lobR
                                                                  		 67391 - 88672 (+) type I modular PKS
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                                                                    • ALA09372.1
                                                                    • lobS
                                                                    		 89289 - 89897 (-) transcriptional regulator
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                                                                      • ALA09373.1
                                                                      • lobT
                                                                      		 89979 - 91712 (+) drug resistance transporter EmrB/QacA
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                                                                        • ALA09374.1
                                                                        • lobU
                                                                        		 92169 - 92804 (+) thioesterase
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                                                                          • ALA09375.1
                                                                          • lobV
                                                                          		 94084 - 96030 (+) transcriptional regulator
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                                                                            • ALA09376.1
                                                                            • lobW
                                                                            		 96015 - 96917 (+) transcriptional regulator
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                                                                              • ALA09377.1
                                                                              • lobX
                                                                              		 97058 - 97864 (+) ABC transporter
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                                                                                • ALA09378.1
                                                                                • lobY
                                                                                		 97864 - 100428 (+) ABC transporter
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                                                                                  • ALA09379.1
                                                                                  • lobZ
                                                                                  		 100629 - 101246 (-) LuxR family DNA-binding response regulator
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                                                                                    • ALA09380.1
                                                                                    • lob1
                                                                                    		 101255 - 102580 (-) sensor histidine kinase
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                                                                                      • ALA09381.1
                                                                                      • lob2
                                                                                      		 102577 - 104091 (-) serine/threonine protein kinase
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                                                                                        • ALA09382.1
                                                                                        • ORF16
                                                                                        		 104444 - 106345 (+) hypothetical protein
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                                                                                          • ALA09383.1
                                                                                          • ORF17
                                                                                          		 106356 - 107378 (+) hypothetical protein
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                                                                                            • ALA09384.1
                                                                                            • ORF18
                                                                                            		 107488 - 108348 (+) hypothetical protein
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                                                                                              Biosynthesis information
                                                                                              Annotation changelog

                                                                                              Entry version: 4

                                                                                              Date
                                                                                              Changes
                                                                                              Submitters
                                                                                              Reviewers
                                                                                              2022-10-07
                                                                                              Update chemical activity to schema version 2.11
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                              Entry version: 3

                                                                                              Date
                                                                                              Changes
                                                                                              Submitters
                                                                                              Reviewers
                                                                                              2022-09-15
                                                                                              Updated bioactivity data
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                              Entry version: 2

                                                                                              Date
                                                                                              Changes
                                                                                              Submitters
                                                                                              Reviewers
                                                                                              2019-10-16
                                                                                              Migrated from v1.4
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              2019-10-16
                                                                                              Updated compound(s) information (NPAtlas curation)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                              Entry version: 1

                                                                                              Date
                                                                                              Changes
                                                                                              Submitters
                                                                                              Reviewers
                                                                                              2015-12-24
                                                                                              Submitted
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                              Detailed domain annotation
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