BGC0001330: BE-43547A1 biosynthetic gene cluster from Micromonospora sp. RV43
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 11,765 - 79,772 nt. (total: 68,008 nt).
This entry is originally from NCBI GenBank NZ_LEKG01000004.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0001330
Short description BE-43547A1 biosynthetic gene cluster from Micromonospora sp. RV43
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
NZ_LEKG01000004.1
20144 - 63730
via
Compounds
  • BE-43547A1
  • BE-43547A2
  • BE-43547B1
  • BE-43547B2
  • BE-43547B3
  • BE-43547C1
  • BE-43547C2
Species Micromonospora sp. RV43 [taxonomy]
References
Chemical products information
BE-43547A1 Evidence: NMR, Mass spectrometry, Total synthesis
Copy SMILES
C30H49N3O7
Chemical database entries
PubCHEM
BE-43547A2 Evidence: Mass spectrometry
Copy SMILES
C30H49N3O7
BE-43547B1 Evidence: Mass spectrometry
Copy SMILES
C31H51N3O7
BE-43547B2 Evidence: Mass spectrometry
Copy SMILES
C31H51N3O7
BE-43547B3 Evidence: Mass spectrometry
Copy SMILES
C31H51N3O7
BE-43547C1 Evidence: Mass spectrometry
Copy SMILES
C32H53N3O7
BE-43547C2 Evidence: Mass spectrometry
Copy SMILES
C32H53N3O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABD52_RS02340
  • WP_047890608.1
 20144 - 21163 (-) NAD(P)-binding domain-containing protein
    copy AA seq
    copy Nt seq
    • ABD52_RS02345
    • WP_200905152.1
    		 21765 - 22760 (+) polyprenyl synthetase family protein
      copy AA seq
      copy Nt seq
      • ABD52_RS02350
      • WP_047890610.1
      		 22870 - 23646 (+) hypothetical protein
        copy AA seq
        copy Nt seq
        • ABD52_RS02355
        • WP_053065262.1
        		 23681 - 24787 (+) 3-dehydroquinate synthase II
          copy AA seq
          copy Nt seq
          • ABD52_RS02360
          • WP_082171176.1
          		 24777 - 25730 (+) UbiA family prenyltransferase
            copy AA seq
            copy Nt seq
            • ABD52_RS02365
            • WP_047890612.1
            		 25777 - 27393 (+) class I adenylate-forming enzyme family protein
              copy AA seq
              copy Nt seq
              • ABD52_RS02370
              • WP_053065263.1
              		 27435 - 28205 (+) hypothetical protein
                copy AA seq
                copy Nt seq
                • ABD52_RS02375
                • WP_053065264.1
                		 28270 - 30507 (+) MMPL family transporter
                  copy AA seq
                  copy Nt seq
                  • ABD52_RS02380
                  • WP_152748170.1
                  		 30624 - 30869 (-) hypothetical protein
                    copy AA seq
                    copy Nt seq
                    • ABD52_RS37315
                    • WP_053065266.1
                    		 31472 - 31960 (+) hypothetical protein
                      copy AA seq
                      copy Nt seq
                      • ABD52_RS02390
                      • WP_047890613.1
                      		 31957 - 32433 (+) flavodoxin domain-containing protein
                        copy AA seq
                        copy Nt seq
                        • ABD52_RS02395
                        • WP_053065267.1
                        		 32475 - 39212 (+) type I polyketide synthase
                          copy AA seq
                          copy Nt seq
                          • ABD52_RS02400
                          • WP_053065268.1
                          		 39214 - 42207 (+) type I polyketide synthase
                            copy AA seq
                            copy Nt seq
                            • ABD52_RS02405
                            • WP_053065269.1
                            		 42204 - 48635 (+) non-ribosomal peptide synthetase
                              copy AA seq
                              copy Nt seq
                              • ABD52_RS02410
                              • WP_047890614.1
                              		 48638 - 54103 (+) type I polyketide synthase
                                copy AA seq
                                copy Nt seq
                                • ABD52_RS02415
                                • WP_053065270.1
                                		 54100 - 59772 (+) non-ribosomal peptide synthetase
                                  copy AA seq
                                  copy Nt seq
                                  • ABD52_RS02420
                                  • WP_047890615.1
                                  		 59769 - 60518 (+) alpha/beta fold hydrolase
                                    copy AA seq
                                    copy Nt seq
                                    • ABD52_RS02425
                                    • WP_047890616.1
                                    		 60570 - 61157 (-) TetR/AcrR family transcriptional regulator
                                      copy AA seq
                                      copy Nt seq
                                      • ABD52_RS02430
                                      • WP_047890617.1
                                      		 61248 - 62174 (+) ABC transporter ATP-binding protein
                                        copy AA seq
                                        copy Nt seq
                                        • ABD52_RS02435
                                        • WP_047890618.1
                                        		 62171 - 63730 (+) hypothetical protein
                                          copy AA seq
                                          copy Nt seq
                                          Biosynthesis information

                                          Biosynthetic modules

                                          Name
                                          3
                                          Type
                                          nrps-type1
                                          Genes
                                          ABD52_RS02405
                                          Substrates
                                          glycine (evidence: Structure-based inference)
                                          Integrated Monomers
                                          Domains
                                          condensation (LCL), adenylation
                                          Name
                                          4
                                          Type
                                          nrps-type1
                                          Genes
                                          ABD52_RS02405
                                          Substrates
                                          serine (evidence: Structure-based inference)
                                          Integrated Monomers
                                          Domains
                                          condensation (LCL), adenylation
                                          Name
                                          6
                                          Type
                                          nrps-type1
                                          Genes
                                          ABD52_RS02415
                                          Substrates
                                          glycine (evidence: Structure-based inference)
                                          Integrated Monomers
                                          Domains
                                          condensation (LCL), adenylation, methyltransferase
                                          Name
                                          0
                                          Type
                                          pks-trans-at-starter
                                          Genes
                                          ABD52_RS02395
                                          Substrates
                                          Integrated Monomers
                                          Domains
                                          ligase, carrier (ACP)
                                          Name
                                          1
                                          Type
                                          pks-modular
                                          Genes
                                          ABD52_RS02395
                                          Substrates
                                          Integrated Monomers
                                          Domains
                                          acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                          Name
                                          2
                                          Type
                                          pks-modular
                                          Genes
                                          ABD52_RS02400
                                          Substrates
                                          Integrated Monomers
                                          Domains
                                          acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                          Name
                                          5
                                          Type
                                          pks-modular
                                          Genes
                                          ABD52_RS02410
                                          Substrates
                                          Integrated Monomers
                                          Domains
                                          acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                          Annotation changelog

                                          Entry version: 4

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-10-07
                                          Update chemical activity to schema version 2.11
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 3

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2022-09-15
                                          Corrected NRP module activity
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2022-09-15
                                          Changed amino acid substrates to lower case
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 2

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2019-10-16
                                          Migrated from v1.4
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          2019-10-16
                                          Updated reference publication(s) (MIBiG Annotathon)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                          Entry version: 1

                                          Date
                                          Changes
                                          Submitters
                                          Reviewers
                                          2018-08-06
                                          Submitted
                                          • (ID: DPAKSDGGIIU3JRGIDNMS7RSG)
                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                          Similar known clusters from MIBiG 4.0
                                          Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                          Detailed help and explanations are available here.

                                          Click on reference genes to show details of similarities to genes within the current region.
                                          Double click on a reference drawing to reverse the display of the genes.

                                          Click on an accession to open that entry in the MIBiG database.


                                          Location:

                                          Identifier
                                          Identity
                                          Coverage
                                          Detailed domain annotation
                                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                          A domain glossary is available here, and an explanation of the visualisation is available here.
                                          Selected features only
                                          Show module domains