BGC0001331: BE-43547A1 biosynthetic gene cluster from Salinispora arenicola CNR107
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 52,394 nt. (total: 52,394 nt).
This entry is originally from NCBI GenBank NZ_KB900339.1, but has been modified (see Modifications tab for details).

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
Modifications
General information about the BGC
MIBiG accession BGC0001331
Short description BE-43547A1 biosynthetic gene cluster from Salinispora arenicola CNR107
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The only prior publication on this class of molecules are a japanese patent from 1998. I put in a placeholder PMID until our paper is accepted."
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
NZ_KB900339.1
10670 - 45645
via
Compounds
  • BE-43547A1
  • BE-43547A2
  • BE-43547B1
  • BE-43547B2
  • BE-43547B3
  • BE-43547C1
  • BE-43547C2
Species Salinispora arenicola CNR107 [taxonomy]
References
Chemical products information
BE-43547A1 Evidence: NMR, Mass spectrometry, Total synthesis
Copy SMILES
C30H49N3O7
BE-43547A2 Evidence: NMR, Mass spectrometry
Copy SMILES
C30H49N3O7
BE-43547B1 Evidence: Mass spectrometry
Copy SMILES
C31H51N3O7
BE-43547B2 Evidence: Mass spectrometry
Copy SMILES
C31H51N3O7
BE-43547B3 Evidence: Mass spectrometry
Copy SMILES
C31H51N3O7
BE-43547C1 Evidence: Mass spectrometry
Copy SMILES
C32H53N3O7
BE-43547C2 Evidence: Mass spectrometry
Copy SMILES
C32H53N3O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Comment Extra
  • F583_RS0124805
  • WP_019032749.1
 10670 - 12229 (-) hypothetical protein
  • Transport
copy AA seq
copy Nt seq
  • F583_RS0124810
  • WP_019032750.1
 12226 - 13152 (-) multidrug ABC transporter ATP-binding protein
  • Transport
copy AA seq
copy Nt seq
  • F583_RS01000000127200
  • WP_080648942.1
 13243 - 13821 (+) TetR/AcrR family transcriptional regulator
    copy AA seq
    copy Nt seq
    • F583_RS0124820
    • WP_019032752.1
    		 13879 - 14628 (-) hypothetical protein
    • Scaffold biosynthesis
    copy AA seq
    copy Nt seq
    • F583_RS01000000127205
    • WP_019032753.1
    		 14625 - 20300 (-) non-ribosomal peptide synthetase
    • Scaffold biosynthesis
    copy AA seq
    copy Nt seq
    • F583_RS0124830
    • WP_019032754.1
    		 20297 - 25753 (-) type I polyketide synthase
    • Scaffold biosynthesis
    copy AA seq
    copy Nt seq
    • F583_RS01000000127210
    • WP_019032755.1
    		 25750 - 32184 (-) non-ribosomal peptide synthetase
    • Scaffold biosynthesis
    copy AA seq
    copy Nt seq
    • F583_RS0124840
    • WP_019032756.1
    		 32181 - 35168 (-) type I polyketide synthase
    • Scaffold biosynthesis
    copy AA seq
    copy Nt seq
    • F583_RS01000000127215
    • WP_019032757.1
    		 35170 - 41919 (-) type I polyketide synthase
    • Scaffold biosynthesis
    copy AA seq
    copy Nt seq
    • F583_RS0124850
    • WP_019032758.1
    		 41961 - 42437 (-) hypothetical protein
    • Tailoring
    copy AA seq
    copy Nt seq
    • F583_RS01000000127220
    • WP_019032759.1
    		 42434 - 42922 (-) hypothetical protein
      copy AA seq
      copy Nt seq
      • F583_RS01000000127225
      • WP_155247000.1
      		 43533 - 43769 (+) hypothetical protein
        copy AA seq
        copy Nt seq
        • F583_RS0124865
        		 43873 - >44205 (-) MMPL family transporter
          copy AA seq
          copy Nt seq
          • F583_RS1000000129165
          • WP_019032762.1
          		 44177 - 44347 (+) hypothetical protein
            copy AA seq
            copy Nt seq
            • F583_RS0124875
            		 44342 - 44587 (-) hypothetical protein
              Derived by automated computational analysis using gene prediction method: GeneMarkS+.
              copy AA seq
              copy Nt seq
              • F583_RS0124880
              • WP_019032764.1
              		 44626 - 45645 (+) NAD(P)-binding domain-containing protein
                copy AA seq
                copy Nt seq
                Biosynthesis information

                Biosynthetic modules

                Name
                3
                Type
                nrps-type1
                Genes
                F583_RS01000000127210
                Substrates
                glycine (evidence: Structure-based inference)
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                4
                Type
                nrps-type1
                Genes
                F583_RS01000000127210
                Substrates
                serine (evidence: Structure-based inference)
                Integrated Monomers
                Domains
                condensation (LCL), adenylation
                Name
                6
                Type
                nrps-type1
                Genes
                F583_RS01000000127205
                Substrates
                glycine (evidence: Structure-based inference)
                Integrated Monomers
                Domains
                condensation (LCL), adenylation, methyltransferase
                Name
                0
                Type
                pks-trans-at-starter
                Genes
                F583_RS01000000127215
                Substrates
                Integrated Monomers
                Domains
                ligase, carrier (ACP)
                Name
                1
                Type
                pks-modular
                Genes
                F583_RS01000000127215
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                Name
                2
                Type
                pks-modular
                Genes
                F583_RS0124840
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                Name
                5
                Type
                pks-modular
                Genes
                F583_RS0124830
                Substrates
                Integrated Monomers
                Domains
                acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                Annotation changelog

                Entry version: 4

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-09-15
                Corrected NRP module activity
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Removed gene names of 'No gene ID'
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Removed extra gene with no information
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2022-09-15
                Changed amino acid substrates to lower case
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2019-10-16
                Updated reference publication(s) (MIBiG Annotathon)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2018-08-06
                Submitted
                • (ID: DPAKSDGGIIU3JRGIDNMS7RSG)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Similar known clusters from MIBiG 4.0
                Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                Detailed help and explanations are available here.

                Click on reference genes to show details of similarities to genes within the current region.
                Double click on a reference drawing to reverse the display of the genes.

                Click on an accession to open that entry in the MIBiG database.


                Location:

                Identifier
                Identity
                Coverage
                Detailed domain annotation
                Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                A domain glossary is available here, and an explanation of the visualisation is available here.
                Selected features only
                Show module domains
                Modifications to original record
                • F583_RS0124875 was added