BGC0001348: JBIR-100 biosynthetic gene cluster from Streptomyces varsoviensis
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Location: 93,200 - 164,000 nt. (total: 70,801 nt).
This entry is originally from NCBI GenBank NZ_JOBF01000033.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0001348
Short description JBIR-100 biosynthetic gene cluster from Streptomyces varsoviensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Macrolide)
Loci NCBI GenBank: NZ_JOBF01000033.1
Compounds
  • JBIR-100
Species Streptomyces varsoviensis [taxonomy]
References
Chemical products information
JBIR-100
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C38H58O10
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Comment Extra
  • IF55_RS40995
  • WP_106980515.1
 93518 - 97492 (+) type I polyketide synthase
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  • IF55_RS32365
  • WP_245661588.1
 97392 - 109040 (+) hypothetical protein
  • Scaffold biosynthesis
Sequence-based prediction
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  • IF55_RS32370
  • WP_048832936.1
 109077 - 124394 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • IF55_RS32375
 124452 - 136256 (+) beta-ketoacyl synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • IF55_RS41000
  • WP_245661582.1
 136405 - 146841 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • IF55_RS36525
 136420 - 142485 (+) polyketide synthase
incomplete; partial in the middle of a contig; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology.
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  • IF55_RS32385
  • WP_063764078.1
 146912 - 153361 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • IF55_RS32390
  • WP_048832937.1
 153358 - 154242 (+) 3-hydroxyacyl-CoA dehydrogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • IF55_RS32395
  • WP_048832938.1
 154316 - 154618 (+) methoxymalonate biosynthesis protein
  • Precursor biosynthesis
Sequence-based prediction
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  • IF55_RS32400
  • WP_078645621.1
 154611 - 155846 (+) acyl-CoA dehydrogenase
  • Precursor biosynthesis
Sequence-based prediction
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  • IF55_RS32405
  • WP_048832952.1
 155903 - 157027 (+) FkbH
  • Precursor biosynthesis
Sequence-based prediction
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  • IF55_RS32410
  • WP_030890472.1
 157127 - 157789 (-) SAM-dependent methyltransferase
  • Precursor biosynthesis
Sequence-based prediction
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  • IF55_RS32415
  • WP_030890475.1
 157866 - 159779 (-) AfsR family transcriptional regulator
  • Regulation
Sequence-based prediction
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  • IF55_RS32420
  • WP_030890478.1
 160255 - 161004 (+) oleoyl-ACP hydrolase
  • Activation / processing
Sequence-based prediction
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  • IF55_RS37870
  • WP_245661583.1
 161192 - 161602 (+) helix-turn-helix transcriptional regulator
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  • IF55_RS32425
 161384 - 161602 (+) transcriptional regulator
  • Unknown
Sequence-based prediction
Derived by automated computational analysis using gene prediction method: Protein Homology.
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  • IF55_RS32430
  • WP_030890486.1
 161943 - 162902 (+) malonyl transferase
  • Unknown
Sequence-based prediction
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  • IF55_RS32435
  • WP_048832939.1
 162899 - 163999 (+) arylcarboxylate reductase
  • Unknown
Sequence-based prediction
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Polyketide-specific information
Subclass Macrolide
Starter unit Isobutyryl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
IF55_RS32420 Synthase subclass: Modular type I
Thioesterases:
  • IF55_RS32420 (Type II)
Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: FTVL3IN3CWSJUJDTYVJJVU23, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Fixed missing and incorrect gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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Modifications to original record
  • IF55_RS36525 was added
  • IF55_RS32425 was added