BGC0001368: JBIR-126 biosynthetic gene cluster from Streptomyces sp. NRRL F-4474
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Location: 141,430 - 183,860 nt. (total: 42,431 nt).
This entry is originally from NCBI GenBank NZ_JOIB01000012.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001368
Short description JBIR-126 biosynthetic gene cluster from Streptomyces sp. NRRL F-4474
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: NZ_JOIB01000012.1
Compounds
  • JBIR-126
Species Streptomyces sp. NRRL F-4474 [taxonomy]
References
Chemical products information
JBIR-126
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C24H30Cl1N5O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • IF33_RS0114760
  • WP_078857608.1
 141432 - 142709 (-) cation:proton antiporter
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  • IF33_RS0114765
  • WP_225884601.1
 142696 - 143316 (-) flavin reductase family protein
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  • IF33_RS0114770
  • WP_030845397.1
 143401 - 145002 (-) tryptophan 7-halogenase
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  • IF33_RS0114775
  • WP_051700101.1
 145178 - 146176 (+) winged helix-turn-helix domain-containing protein
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  • IF33_RS0114780
  • WP_030845402.1
 146304 - 147815 (+) aldehyde dehydrogenase family protein
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  • IF33_RS0114785
  • WP_078857609.1
 147812 - 149644 (+) non-ribosomal peptide synthetase
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  • IF33_RS0114790
  • WP_051700103.1
 149648 - 150394 (+) alpha/beta fold hydrolase
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  • IF33_RS0114795
  • WP_076043097.1
 150411 - 150614 (+) MbtH family NRPS accessory protein
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  • IF33_RS0114800
  • WP_030845407.1
 150616 - 151830 (+) cytochrome P450
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  • IF33_RS0114805
  • WP_051700105.1
 151846 - 155784 (+) non-ribosomal peptide synthetase
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  • IF33_RS36805
  • WP_051700107.1
 155784 - 156428 (+) 4'-phosphopantetheinyl transferase superfamily protein
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  • IF33_RS0114815
  • WP_030845410.1
 156441 - 157472 (+) winged helix DNA-binding domain-containing protein
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  • IF33_RS0114820
  • WP_051700109.1
 157592 - 158869 (+) MFS transporter
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  • IF33_RS0114825
  • WP_051700111.1
 159041 - 163132 (+) non-ribosomal peptide synthetase
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  • IF33_RS0114830
  • WP_051700112.1
 163125 - 166481 (+) non-ribosomal peptide synthetase
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  • IF33_RS0114835
  • WP_030845415.1
 166481 - 167887 (+) condensation domain-containing protein
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  • IF33_RS0114840
  • WP_051700115.1
 167967 - 169157 (+) acyl-CoA dehydrogenase family protein
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  • IF33_RS0114845
  • WP_030845419.1
 169154 - 170299 (+) hypothetical protein
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  • IF33_RS0114850
  • WP_030845421.1
 170368 - 170949 (-) GNAT family N-acetyltransferase
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  • IF33_RS0114855
  • WP_078857612.1
 170976 - 172046 (-) beta-eliminating lyase-related protein
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  • IF33_RS0114860
  • WP_051700119.1
 172043 - 172732 (-) DUF2461 domain-containing protein
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  • IF33_RS0114865
  • WP_078857614.1
 172729 - 174129 (-) serine hydroxymethyltransferase
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  • IF33_RS0114870
  • WP_051700122.1
 174184 - 177474 (-) non-ribosomal peptide synthetase
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  • IF33_RS0114875
  • WP_078857623.1
 177565 - 179439 (-) NB-ARC domain-containing protein
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  • IF33_RS0114880
  • WP_030845436.1
 179641 - 179847 (+) hypothetical protein
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  • IF33_RS41965
  • WP_234331000.1
 179976 - 180686 (-) tetratricopeptide repeat protein
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  • IF33_RS41970
 181617 - 182921 (-) NB-ARC domain-containing protein
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  • IF33_RS0114890
  • WP_030845442.1
 183161 - 183631 (-) MarR family transcriptional regulator
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
IF33_RS0114805
Module ?
Specificity: 6-chlorotryptophan
Evidence for specificity:
  • Structure-based inference
  • Homology
IF33_RS0114870
Module ?
Specificity: 6-chloro-4-hydroxy-1-methyl-indole-3-carboxylic acid
Evidence for specificity:
  • Structure-based inference
  • Homology
IF33_RS0114785
Module ?
Specificity: 2-methylserine
Evidence for specificity:
  • Structure-based inference
  • Feeding study
  • Homology
IF33_RS0114825
Module ?
Specificity: lysine
Evidence for specificity:
  • Structure-based inference
  • Homology
IF33_RS0114830
Module ?
Specificity: 2-methylserine
Evidence for specificity:
  • Structure-based inference
  • Feeding study
Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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