BGC0001370: lipopeptide 8D1-1 biosynthetic gene cluster from Streptomyces rochei
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Location: 1 - 79,876 nt. (total: 79,876 nt).
This entry is originally from NCBI GenBank KT362047.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0001370
Short description lipopeptide 8D1-1 biosynthetic gene cluster from Streptomyces rochei
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
Loci NCBI GenBank: KT362047.1
Compounds
  • lipopeptide 8D1-1
  • lipopeptide 8D1-2
Species Streptomyces rochei [taxonomy]
References
Chemical products information
lipopeptide 8D1-1
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C66H82N14O27
lipopeptide 8D1-2
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C66H84N14O28
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ALV82383.1
 11 - 1630 (+) ABC transporter
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  • ALV82361.1
 2626 - 4263 (+) regulator
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  • ALV82382.1
 4330 - 4545 (-) putative mbtH protein
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  • ALV82365.1
 4676 - 5842 (-) lipase
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  • ALV82351.1
 6073 - 6504 (-) putative secreted protein
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  • ALV82369.1
 6577 - 7434 (-) prephenate dehydrogenase
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  • ALV82372.1
 7515 - 7970 (-) putative secreted protein
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  • ALV82348.1
 8152 - 8910 (-) ABC transporter
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  • ALV82359.1
 8956 - 9909 (-) ABC transporter ATP-binding protein
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  • ALV82374.1
 9932 - 10051 (-) hypothetical protein
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  • ALV82363.1
 10046 - 11761 (+) two component sensor kinase
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  • ALV82366.1
 11780 - 12448 (+) regulator
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  • ALV82375.1
 12463 - 13788 (-) putative aminotransferase
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  • ALV82386.1
 13785 - 14984 (-) putative oxidase
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  • ALV82353.1
 14981 - 16054 (-) 4-hydroxyphenylpyruvic acid dioxygenase
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  • ALV82390.1
 16163 - 16393 (-) hypothetical protein
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  • ALV82356.1
  • cda2PSI
 16367 - 38248 (+) CDA peptide synthetase I
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  • ALV82384.1
  • cda2PS2
 38245 - 49158 (+) CDA peptide synthetase II
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  • ALV82388.1
  • cda2PS3
 49143 - 56366 (+) CDA peptide synthetase III
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  • ALV82377.1
 56371 - 57189 (+) hydrolase
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  • ALV82370.1
 57201 - 58094 (+) phosphotransferase
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  • ALV82355.1
 58162 - 60012 (-) ABC transporter
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  • ALV82360.1
 60052 - 61053 (-) oxygenase
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  • ALV82380.1
 61236 - 62039 (-) secreted protein
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  • ALV82350.1
 62093 - 63310 (-) salicylate hydroxylase
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  • ALV82391.1
 63341 - 64327 (-) 3-oxoacyl-[acyl carrier protein] synthase, KASIII
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  • ALV82371.1
 64324 - 66051 (-) acyl-CoA oxidase
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  • ALV82387.1
 66150 - 67370 (-) 3-oxoacyl-[acyl-carrier-protein] synthase, KASII
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  • ALV82381.1
 67367 - 67612 (-) acyl carrier protein
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  • ALV82385.1
 67632 - 67949 (-) hypothetical protein
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  • ALV82352.1
 68240 - 68770 (-) DNA-binding protein
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  • ALV82362.1
 69081 - 69662 (+) membrane protein
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  • ALV82378.1
 70038 - 70583 (+) hypothetical protein
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  • ALV82358.1
 70677 - 71183 (-) flavodoxin
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  • ALV82376.1
 71200 - 71931 (-) hypothetical protein
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  • ALV82373.1
 71944 - 72084 (-) hypothetical protein
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  • ALV82354.1
 72387 - 73250 (-) universal stress protein
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  • ALV82389.1
 73256 - 74278 (-) alcohol dehydrogenase
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  • ALV82357.1
 74317 - 75243 (-) stress-inducible protein
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  • ALV82368.1
 75375 - 75875 (-) membrane protein
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  • ALV82379.1
 76256 - 77176 (-) stress-inducible protein
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  • ALV82367.1
 77301 - 78224 (-) carbamate kinase
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  • ALV82349.1
 78228 - 79229 (-) ornithine carbamoyltransferase
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  • ALV82364.1
 79252 - 79794 (-) arginine deiminase
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
cda2PSI
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: 4-hydroxyphenylglycine
Evidence for specificity:
  • Structure-based inference
cda2PS2
Module ?
Specificity: aspartic acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: asparagine / 3-hydroxyasparagine
Evidence for specificity:
  • Structure-based inference
  • Knock-out studies
cda2PS3
Module ?
Specificity: glutamic acid
Evidence for specificity:
  • Structure-based inference
Module ?
Specificity: tryptophan
Evidence for specificity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.3
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added NRP substrate specificities
Detailed domain annotation
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