BGC0001381: brasilinolide A biosynthetic gene cluster from Nocardia terpenica
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Location: 1 - 210,303 nt. (total: 210,303 nt).
This entry is originally from NCBI GenBank KP161205.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
Modifications
General information about the BGC
MIBiG accession BGC0001381
Short description brasilinolide A biosynthetic gene cluster from Nocardia terpenica
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
KP161205.1
via
Compounds
  • brasilinolide A
  • brasilinolide B
  • brasilinolide C
Species Nocardia terpenica [taxonomy]
References
Chemical products information
brasilinolide A Evidence:
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C57H98O24
Chemical database entries
NPAtlas
PubCHEM
brasilinolide B Evidence:
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C59H104O23
Chemical database entries
NPAtlas
PubCHEM
brasilinolide C Evidence:
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C49H88O20
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AJO72694.1
 <1 - 516 (-) hypothetical protein
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    • AJO72695.1
    		 513 - 1166 (-) hypothetical protein
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      • AJO72696.1
      		 1498 - 2325 (+) Peptidase
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        • AJO72697.1
        		 2322 - 2885 (-) Tellurite resistance protein
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          • AJO72698.1
          • nbrT4
          		 3082 - 3774 (-) Major intrinsic protein/permease
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            • AJO72699.1
            • nbrR6
            		 3942 - 4553 (+) TetR family transcriptional regulator
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              • AJO72700.1
              		 4534 - 5418 (-) SAM-dependent methyltransferase
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                • AJO72701.1
                		 5476 - 6081 (+) HAD-superfamily hydrolase
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                  • AJO72702.1
                  		 6404 - 9877 (+) Acyl-CoA ligase/oxidoreductase
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                    • AJO72703.1
                    		 10491 - 11714 (+) Kynureninase
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                      • AJO72704.1
                      		 11829 - 12791 (-) Glyoxalase/antibiotic resistance protein/dioxygenase
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                        • AJO72705.1
                        		 12784 - 14529 (-) Monooxygenase
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                          • AJO72706.1
                          • nbrR5
                          		 14638 - 15429 (+) IclR family transcriptional regulator
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                            • AJO72707.1
                            • nbrR4
                            		 15543 - 15905 (-) Lsr2-like protein
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                              • AJO72708.1
                              • nbrR3
                              		 16234 - 17172 (-) MerR family transcriptional regulator
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                                • AJO72709.1
                                		 17299 - 17736 (+) hypothetical protein
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                                  • AJO72710.1
                                  • nbrR2
                                  		 17751 - 18866 (-) AbrB family membrane protein/regulator
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                                    • AJO72711.1
                                    		 18872 - 19354 (+) hypothetical protein
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                                      • AJO72712.1
                                      		 19363 - 22830 (-) DNA-directed RNA polymerase subunit beta
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                                        • AJO72713.1
                                        		 23101 - 23499 (+) hypothetical protein
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                                          • AJO72714.1
                                          		 23607 - 23957 (-) hypothetical protein
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                                            • AJO72715.1
                                            • nbrR1
                                            		 24299 - 25051 (+) LuxR family transcriptional regulator
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                                              • AJO72716.1
                                              • nbrP
                                              		 25110 - 26342 (-) Cytochrome P450 monooxygenase
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                                                • AJO72717.1
                                                		 26559 - 29669 (+) adenylation domain-containing protein
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                                                  • AJO72718.1
                                                  • nbrT3
                                                  		 29666 - 30511 (+) ABC-2 type transporter
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                                                    • AJO72719.1
                                                    • nbrD
                                                    		 30516 - 31502 (+) dTDP-4-keto-6-deoxy-hexose 2,3-reductase
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                                                      • AJO72720.1
                                                      • nbrE
                                                      		 31528 - 32133 (+) dTDP-4-keto-6-deoxy-hexose 3,5-epimerase
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                                                        • AJO72721.1
                                                        • nbrF
                                                        		 32147 - 33088 (+) dTDP-4-keto-6-deoxy-hexose 4-ketoreductase
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                                                          • AJO72722.1
                                                          • nbrT1
                                                          		 33248 - 34228 (+) Antibiotic ABC transporter ATPase
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                                                            • AJO72723.1
                                                            • nbrT2
                                                            		 34225 - 35064 (+) ABC-2 type transporter
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                                                              • AJO72724.1
                                                              • nbrC
                                                              		 35092 - 36513 (+) dTDP-4-keto-6-deoxy-hexose 2,3-dehydratase
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                                                                • AJO72725.1
                                                                • nbrM
                                                                		 36517 - 37152 (-) Thymidylate kinase
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                                                                  • AJO72726.1
                                                                  		 37342 - 38442 (-) hypothetical protein
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                                                                    • AJO72727.1
                                                                    • nbrS1
                                                                    		 38714 - 39982 (-) PapA5 Acyltransferase
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                                                                      • AJO72728.1
                                                                      • nbrQ1
                                                                      		 40001 - 41107 (-) AMP-binding protein
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                                                                        • AJO72729.1
                                                                        • nbrQ2
                                                                        		 41104 - 42534 (-) MmgE/PrpD family protein
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                                                                          • AJO72730.1
                                                                          • nbrQ3
                                                                          		 42531 - 43370 (-) putative cyclase
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                                                                            • AJO72731.1
                                                                            • nbrQ4
                                                                            		 43367 - 44248 (-) putative Citrate lyase beta subunit
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                                                                              • AJO72732.1
                                                                              • nbrQ5
                                                                              		 44245 - 45447 (-) Acyl-CoA transferase
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                                                                                • AJO72733.1
                                                                                • nbrS2
                                                                                		 45654 - 47003 (+) Type B carboxylesterase/acyltransferase
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                                                                                  • AJO72734.1
                                                                                  • nbrK
                                                                                  		 47333 - 60052 (+) Type I modular polyketide synthase
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                                                                                    • AJO72735.1
                                                                                    • nbrL
                                                                                    		 60104 - 74758 (+) Type I modular polyketide synthase
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                                                                                      • AJO72736.1
                                                                                      • nbrG
                                                                                      		 74836 - 99387 (+) Type I modular polyketide synthase
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                                                                                        • AJO72737.1
                                                                                        • nbrH
                                                                                        		 99416 - 119593 (+) Type I modular polyketide synthase
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                                                                                          • AJO72738.1
                                                                                          • nbrA
                                                                                          		 119605 - 120864 (+) Glycosyltransferase
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                                                                                            • AJO72739.1
                                                                                            • nbrR7
                                                                                            		 120914 - 121648 (+) TetR/AcrR family transcriptional regulator
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                                                                                              • AJO72740.1
                                                                                              • nbrB
                                                                                              		 122135 - 123346 (+) MGT family glycosyltransferase
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                                                                                                • AJO72741.1
                                                                                                • nbrV
                                                                                                		 123429 - 124703 (+) Cytochrome P450 monooxygenase
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                                                                                                  • AJO72742.1
                                                                                                  • nbrI
                                                                                                  		 124717 - 135606 (+) Type I modular polyketide synthase
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                                                                                                    • AJO72743.1
                                                                                                    • nbrJ
                                                                                                    		 135628 - 144387 (+) Type I modular polyketide synthase
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                                                                                                      • AJO72744.1
                                                                                                      • nbrO
                                                                                                      		 144496 - 145248 (+) Type II thioesterase
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                                                                                                        • AJO72745.1
                                                                                                        • nbrS3
                                                                                                        		 145963 - 146778 (+) alpha/beta-Hydrolase or acyltransferase
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                                                                                                          • AJO72746.1
                                                                                                          • nbrN
                                                                                                          		 146982 - 147848 (-) Glucose-1-phosphate thymidylyltransferase
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                                                                                                            • AJO72747.1
                                                                                                            • nbrT5
                                                                                                            		 147888 - 148652 (-) putative membrane protein
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                                                                                                              • AJO72748.1
                                                                                                              • nbrR8
                                                                                                              		 150022 - 151659 (+) LuxR family transcriptional regulator
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                                                                                                                • AJO72749.1
                                                                                                                		 151839 - 153368 (+) Polyprenyl phospho-mannosyltransferase
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                                                                                                                  • AJO72750.1
                                                                                                                  • nbrR9
                                                                                                                  		 154077 - 154697 (-) TetR family transcriptional regulator
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                                                                                                                    • AJO72751.1
                                                                                                                    		 154819 - 157857 (+) alpha-Mannosidase
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                                                                                                                      • AJO72752.1
                                                                                                                      • nbrU
                                                                                                                      		 158110 - 159432 (+) Crotonyl-CoA carboxylase/reductase
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                                                                                                                        • AJO72753.1
                                                                                                                        		 159461 - 160114 (+) HAD-superfamily hydrolase
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                                                                                                                          • AJO72754.1
                                                                                                                          		 160578 - 161561 (-) beta-Ribofuranosylaminobenzene 5'-phosphate synthase
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                                                                                                                            • AJO72755.1
                                                                                                                            		 161609 - 162610 (-) Phosphoribosylaminoimidazole-succinocarboxamide synthase
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                                                                                                                              • AJO72756.1
                                                                                                                              		 162812 - 164419 (-) Fumarate reductase/succinate dehydrogenase
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                                                                                                                                • AJO72757.1
                                                                                                                                		 164452 - 165021 (-) NADPH-dependent FMN reductase
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                                                                                                                                  • AJO72758.1
                                                                                                                                  		 165060 - 166241 (-) amidohydrolase
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                                                                                                                                    • AJO72759.1
                                                                                                                                    • nbrT6
                                                                                                                                    		 166241 - 167449 (-) MFS transporter
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                                                                                                                                      • AJO72760.1
                                                                                                                                      		 167484 - 168914 (-) Adenylosuccinate lyase
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                                                                                                                                        • AJO72761.1
                                                                                                                                        		 168926 - 170152 (-) Arene(phthalate) dioxygenase
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                                                                                                                                          • AJO72762.1
                                                                                                                                          		 170169 - 172199 (-) Methionine-tRNA ligase
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                                                                                                                                            • AJO72763.1
                                                                                                                                            		 172196 - 173524 (-) L-Lysine 6-monooxygenase
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                                                                                                                                              • AJO72764.1
                                                                                                                                              		 173521 - 174723 (-) Saccharopine dehydrogenase
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                                                                                                                                                • AJO72765.1
                                                                                                                                                		 174734 - 175984 (-) Phosphoribosylglycinamide synthetase
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                                                                                                                                                  • AJO72766.1
                                                                                                                                                  		 176152 - 177261 (+) (Glycated) amino acid oxidase
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                                                                                                                                                    • AJO72767.1
                                                                                                                                                    		 177675 - 178697 (+) Monooxygenase
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                                                                                                                                                      • AJO72768.1
                                                                                                                                                      		 178703 - 180025 (+) Monooxygenase
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                                                                                                                                                        • AJO72769.1
                                                                                                                                                        • nbrR10
                                                                                                                                                        		 180039 - 180935 (+) Transcriptional regulator
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                                                                                                                                                          • AJO72770.1
                                                                                                                                                          		 181132 - 181593 (+) hypothetical protein
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                                                                                                                                                            • AJO72771.1
                                                                                                                                                            		 181620 - 182345 (-) hypothetical protein
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                                                                                                                                                              • AJO72772.1
                                                                                                                                                              		 182812 - 183363 (-) ArsR family transcriptional regulator
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                                                                                                                                                                • AJO72773.1
                                                                                                                                                                		 183454 - 184719 (+) hypothetical protein
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                                                                                                                                                                  • AJO72774.1
                                                                                                                                                                  		 185177 - 185617 (-) MarR family transcriptional regulator
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                                                                                                                                                                    • AJO72775.1
                                                                                                                                                                    		 186303 - 186608 (+) hypothetical protein
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                                                                                                                                                                      • AJO72776.1
                                                                                                                                                                      		 186605 - 188671 (+) hypothetical protein
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                                                                                                                                                                        • AJO72777.1
                                                                                                                                                                        		 188668 - 189021 (+) hypothetical protein
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                                                                                                                                                                          • AJO72778.1
                                                                                                                                                                          		 189241 - 189792 (+) hypothetical protein
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                                                                                                                                                                            • AJO72779.1
                                                                                                                                                                            		 189797 - 190243 (+) YbaB/EbfC DNA-binding protein
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                                                                                                                                                                              • AJO72780.1
                                                                                                                                                                              		 190325 - 190648 (+) putative surface-exposed protein
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                                                                                                                                                                                • AJO72781.1
                                                                                                                                                                                		 190664 - 191674 (+) hypothetical protein
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                                                                                                                                                                                  • AJO72782.1
                                                                                                                                                                                  		 192408 - 193742 (-) hypothetical protein
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                                                                                                                                                                                    • AJO72783.1
                                                                                                                                                                                    		 194523 - 195779 (-) hypothetical protein
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                                                                                                                                                                                      • AJO72784.1
                                                                                                                                                                                      		 195964 - 196494 (+) hypothetical protein
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                                                                                                                                                                                        • AJO72785.1
                                                                                                                                                                                        		 198311 - 199093 (+) hypothetical protein
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                                                                                                                                                                                          • AJO72786.1
                                                                                                                                                                                          		 199483 - 200106 (+) hypothetical protein
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                                                                                                                                                                                            • AJO72787.1
                                                                                                                                                                                            		 200185 - 200553 (+) hypothetical protein
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                                                                                                                                                                                              • AJO72788.1
                                                                                                                                                                                              		 201103 - 201591 (+) hypothetical protein
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                                                                                                                                                                                                • AJO72789.1
                                                                                                                                                                                                		 202274 - 202546 (-) hypothetical protein
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                                                                                                                                                                                                  • AJO72790.1
                                                                                                                                                                                                  		 202685 - 203083 (-) hypothetical protein
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                                                                                                                                                                                                    • AJO72791.1
                                                                                                                                                                                                    		 204148 - 205044 (+) Lipase
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                                                                                                                                                                                                      • AJO72792.1
                                                                                                                                                                                                      • Putative_phenazine_biosynthesis_protein
                                                                                                                                                                                                      		 206736 - 207920 (+) Adenylase
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                                                                                                                                                                                                        • AJO72793.1
                                                                                                                                                                                                        • Putative_phenazine_biosynthesis_protein_rename1
                                                                                                                                                                                                        		 207920 - 209344 (+) Arylcarboxylate reductase
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                                                                                                                                                                                                          • AJO72794.1
                                                                                                                                                                                                          		 209327 - 210082 (-) putative antiporter/lipoprotein
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                                                                                                                                                                                                            Biosynthesis information

                                                                                                                                                                                                            No biosynthesis information available for this record.

                                                                                                                                                                                                            Annotation changelog

                                                                                                                                                                                                            Entry version: 4

                                                                                                                                                                                                            Date
                                                                                                                                                                                                            Changes
                                                                                                                                                                                                            Submitters
                                                                                                                                                                                                            Reviewers
                                                                                                                                                                                                            2022-10-07
                                                                                                                                                                                                            Update chemical activity to schema version 2.11
                                                                                                                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                                                                            Entry version: 3

                                                                                                                                                                                                            Date
                                                                                                                                                                                                            Changes
                                                                                                                                                                                                            Submitters
                                                                                                                                                                                                            Reviewers
                                                                                                                                                                                                            2022-09-15
                                                                                                                                                                                                            Updated bioactivity data
                                                                                                                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                                                                            Entry version: 2

                                                                                                                                                                                                            Date
                                                                                                                                                                                                            Changes
                                                                                                                                                                                                            Submitters
                                                                                                                                                                                                            Reviewers
                                                                                                                                                                                                            2019-10-16
                                                                                                                                                                                                            Migrated from v1.4
                                                                                                                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                            2019-10-16
                                                                                                                                                                                                            Updated compound(s) information (NPAtlas curation)
                                                                                                                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                                                                            Entry version: 1

                                                                                                                                                                                                            Date
                                                                                                                                                                                                            Changes
                                                                                                                                                                                                            Submitters
                                                                                                                                                                                                            Reviewers
                                                                                                                                                                                                            2016-09-03
                                                                                                                                                                                                            Submitted
                                                                                                                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                                                                                                                                                                                            Detailed domain annotation
                                                                                                                                                                                                            Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
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                                                                                                                                                                                                            Modifications to original record
                                                                                                                                                                                                            • renamed CDS with name Putative_phenazine_biosynthesis_protein at [207919:209344](+) to Putative_phenazine_biosynthesis_protein_rename1 to avoid duplicates