BGC0001435: ikarugamycin biosynthetic gene cluster from Streptomyces sp. ZJ306
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Location: 1 - 36,760 nt. (total: 36,760 nt).
This entry is originally from NCBI GenBank KF954512.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0001435
Short description ikarugamycin biosynthetic gene cluster from Streptomyces sp. ZJ306
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Please note that I was not involved in the studies on the mechanism and genes involved in the biosynthesis of Ikarugamycin, I am submitting this entry as part of study on the evolution of polycyclic tetramate macromalctams."
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: KF954512.1
Compounds
  • ikarugamycin
Species Streptomyces sp. ZJ306 [taxonomy]
References
Chemical products information
ikarugamycin
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C29H38N2O4
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AJD77019.1
 201 - 1010 (-) hydroxylase
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  • AJD77020.1
 1105 - 1860 (-) deacetylase
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  • AJD77021.1
 2023 - 2394 (+) hypothetical protein
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  • AJD77022.1
 2455 - 3036 (+) hypothetical protein
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  • AJD77023.1
 3411 - 12785 (+) IkaA
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  • AJD77024.1
 12782 - 14614 (+) IkaB
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  • AJD77025.1
 14614 - 15678 (+) IkaC
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  • AJD77026.1
 15811 - 16281 (-) GCN5-related N-acetyltransferase
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  • AJD77027.1
 16379 - 17107 (-) hypothetical protein
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  • AJD77028.1
 17100 - 18908 (-) asparagine synthase
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  • AJD77029.1
 19327 - 20634 (+) transcriptional regulator
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  • AJD77030.1
 20762 - 21157 (-) ABC transporter
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  • AJD77031.1
 21353 - 22717 (+) hypothetical protein
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  • AJD77032.1
 22885 - 23628 (+) hypothetical protein
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  • AJD77033.1
 23766 - 24341 (+) putative membrane transport protein
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  • AJD77034.1
 24945 - 25427 (+) putative acetyltransferase
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  • AJD77035.1
 25512 - 26912 (-) cytochrome P450
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  • AJD77036.1
 26969 - 28987 (-) putative alpha-glucosidase
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  • AJD77037.1
 28974 - 31478 (+) phosphoketolase
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  • AJD77038.1
 31491 - 32369 (-) helix-turn-helix domain-containing protein
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  • AJD77039.1
 32494 - 33048 (-) membrane protein
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  • AJD77040.1
 33153 - 34250 (+) NAD-dependent epimerase/dehydratase
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  • AJD77041.1
 34251 - 34805 (+) RNA polymerase, sigma-24 subunit
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  • AJD77042.1
 34802 - 35674 (+) hypothetical protein
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  • AJD77043.1
 35748 - 36599 (+) hypothetical protein
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Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Cyclic? yes
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
AJD77023.1 Synthase subclass: Iterative type I
Iterative PKS type: Partially reducing, Unknown
Iteration counts: 6
NRP-specific information
Subclass N/A
Cyclic? no
Release type
  • Hydrolysis
Thioesterase genes
  • AJD77023.1 (Type I)
Annotation changelog
MIBiG version Submitter Notes
1.4
  • Hidden contributor (ID: FLY65ZCPMC2MOEEXU6QSP7DO, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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